MCID: XLN230
MIFTS: 17

X-Linked Monogenic Disease

Categories: Genetic diseases

Aliases & Classifications for X-Linked Monogenic Disease

MalaCards integrated aliases for X-Linked Monogenic Disease:

Name: X-Linked Monogenic Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050735

Summaries for X-Linked Monogenic Disease

Disease Ontology : 12 A monogenic disease that has material basis in muations in genes on the X chromosome.

MalaCards based summary : X-Linked Monogenic Disease is related to x-linked recessive disease and bacterial infectious disease. An important gene associated with X-Linked Monogenic Disease is H2AC18 (H2A Clustered Histone 18).

Related Diseases for X-Linked Monogenic Disease

Diseases in the Y-Linked Monogenic Disease family:

X-Linked Monogenic Disease

Diseases related to X-Linked Monogenic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 x-linked recessive disease 32.5 WAS UTRN U2AF1 SERPINA3 PRODH OCRL
2 bacterial infectious disease 10.6 SERPINA3 ICOSLG H2AC18 CCR6
3 autoimmune disease of cardiovascular system 10.6 SERPINA3 ICOSLG H2AC18 CCR6
4 autoimmune disease of skin and connective tissue 10.6 SERPINA3 ICOSLG H2AC18 CCR6
5 hypersensitivity reaction type iv disease 10.6 SERPINA3 ICOSLG H2AC18 CCR6
6 commensal bacterial infectious disease 10.6 SERPINA3 ICOSLG H2AC18 CCR6
7 parasitic helminthiasis infectious disease 10.6 SERPINA3 ICOSLG H2AC18 CCR6
8 salivary gland disease 10.6 SERPINA3 ICOSLG H2AC18 CCR6
9 autoimmune disease of urogenital tract 10.6 ICOSLG H2AC18 CCR6
10 mast cell neoplasm 10.6 U2AF1 SERPINA3 ICOSLG H2AC18
11 klebsiella pneumonia 10.6 ICOSLG H2AC18 CCR6
12 autoimmune disease of endocrine system 10.6 MIR142 ICOSLG H2AC18 CCR6
13 extrinsic cardiomyopathy 10.6 SERPINA3 MIR142 ICOSLG H2AC18 CCR6
14 spinal cord disease 10.6 MIR142 ICOSLG H2AC18 CCR6
15 hair disease 10.6 SERPINA3 ICOSLG H2AC18 ERCC6 CCR6
16 cytoplasmic body myopathy 10.6 UTRN DMD
17 bacterial pneumonia 10.6 SERPINA3 ICOSLG H2AC18 CCR6
18 progressive relapsing multiple sclerosis 10.6 SERPINA3 H2AC18 CCR6
19 autoimmune disease of eyes, ear, nose and throat 10.6 ICOSLG CRYAA CCR6
20 teeth hard tissue disease 10.6 SERPINA3 H2AC18 ERCC6 CCR6
21 chediak-higashi syndrome 10.6 SERPINA3 PRODH ICOSLG H2AC18 CCR6
22 bronchial disease 10.6 SERPINA3 MIR142 ICOSLG H2AC18 CCR6
23 intrinsic cardiomyopathy 10.6 SERPINA3 MIR142 ICOSLG H2AC18 DMD
24 testicular disease 10.6 SERPINA3 H2AC18 ERCC6 CCR6
25 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.6 ICOSLG H2AC18 CCR6
26 cranial nerve disease 10.6 SERPINA3 ICOSLG ERCC6 CRYAA CCR6
27 corneal disease 10.6 SERPINA3 H2AC18 ERCC6 CRYAA CCR6
28 leukocyte disease 10.6 U2AF1 SERPINA3 MIR142 ICOSLG H2AC18 CCR6
29 autoimmune disease of gastrointestinal tract 10.6 SERPINA3 MIR24-1 MIR142 ICOSLG H2AC18 CCR6
30 hypersensitivity reaction type iii disease 10.6 SERPINA3 ICOSLG CCR6
31 pre-malignant neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6
32 thyroid gland disease 10.6 SERPINA3 MIR9-1 MIR142 ICOSLG H2AC18 CCR6
33 mental depression 10.6 SERPINA3 PRODH MIR24-1 H2AC18 CCR6
34 herpangina 10.6 ICOSLG H2AC18 CCR6
35 mature b-cell neoplasm 10.6 U2AF1 MIR9-1 MIR142 ICOSLG H2AC18 CCR6
36 lymphangioma 10.6 SERPINA3 H2AC18 ERCC6 CCR6
37 autoimmune disease of blood 10.6 SERPINA3 ICOSLG CCR6
38 lacrimal apparatus disease 10.6 ICOSLG CRYAA CCR6
39 intestinal benign neoplasm 10.6 SERPINA3 MIR142 H2AC18 ERCC6 CCR6
40 degeneration of macula and posterior pole 10.6 SERPINA3 H2AC18 ERCC6 CRYAA
41 bone resorption disease 10.6 SERPINA3 MIR142 H2AC18 ERCC6 CCR6
42 malignant ovarian surface epithelial-stromal neoplasm 10.6 SERPINA3 MIR9-1 ICOSLG H2AC18 ERCC6 CCR6
43 speech disorder 10.6 PRODH H2AC18 FMR1 CFAP47
44 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR142 H2AC18 ERCC6 CCR6
45 brachydactyly, type d 10.6 H2AC18 F9 F8
46 bile duct adenocarcinoma 10.6 SERPINA3 MIR9-1 MIR142 H2AC18 CCR6
47 listeriosis 10.6 ICOSLG H2AC18 CCR6
48 bile duct disease 10.6 SERPINA3 MIR9-1 MIR142 ICOSLG H2AC18 CCR6
49 autoimmune disease of musculoskeletal system 10.6 SERPINA3 MIR24-1 MIR142 ICOSLG H2AC18 CCR6
50 learning disability 10.6 PRODH MIR9-1 H2AC18 FMR1 CFAP47

Graphical network of the top 20 diseases related to X-Linked Monogenic Disease:



Diseases related to X-Linked Monogenic Disease

Symptoms & Phenotypes for X-Linked Monogenic Disease

Drugs & Therapeutics for X-Linked Monogenic Disease

Search Clinical Trials , NIH Clinical Center for X-Linked Monogenic Disease

Genetic Tests for X-Linked Monogenic Disease

Anatomical Context for X-Linked Monogenic Disease

Publications for X-Linked Monogenic Disease

Articles related to X-Linked Monogenic Disease:

# Title Authors PMID Year
1
Preimplantation genetic diagnosis for monogenic diseases: overview and emerging issues. 61
17187482 2007

Variations for X-Linked Monogenic Disease

Expression for X-Linked Monogenic Disease

Search GEO for disease gene expression data for X-Linked Monogenic Disease.

Pathways for X-Linked Monogenic Disease

GO Terms for X-Linked Monogenic Disease

Biological processes related to X-Linked Monogenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of double-strand break repair via homologous recombination GO:1905168 8.96 WAS ERCC6
2 response to denervation involved in regulation of muscle adaptation GO:0014894 8.62 UTRN DMD

Molecular functions related to X-Linked Monogenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vinculin binding GO:0017166 8.96 UTRN DMD
2 mRNA 3'-UTR binding GO:0003730 8.92 MIR9-1 MIR24-1 MIR142 FMR1

Sources for X-Linked Monogenic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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