Xeroderma Pigmentosum, Complementation Group B disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Xeroderma Pigmentosum, Complementation Group B

MalaCards integrated aliases for Xeroderma Pigmentosum, Complementation Group B:

Name: Xeroderma Pigmentosum, Complementation Group B ⁵⁷ ²⁹ ⁶ ⁴⁰

Xeroderma Pigmentosum, Group B ⁵⁷ ¹³ ⁷³

Xeroderma Pigmentosum Group B ¹² ¹⁵

Xp Group B ¹² ⁷⁵

Xpbc ⁵⁷ ¹²

Xpb ⁵⁷ ¹²

Xeroderma Pigmentosum Group B with Cockayne Syndrome ⁷⁵

Xeroderma Pigmentosum Complementation Group B ⁷⁵

Xeroderma Pigmentosum Ii ⁷⁵

Xp, Group B; Xpbc ⁵⁷

Xp, Group B ⁵⁷

Xp-B/cs ⁷⁵

Xp-B ⁷⁵

Xp2 ⁷⁵

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal recessive

HPO:

³²

xeroderma pigmentosum, complementation group b:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Congenital malformations, deformations and chromosomal abnormalities

Other congenital malformations

Other congenital malformations of skin

Xeroderma pigmentosum

External Ids:

OMIM ⁵⁷ 610651

Disease Ontology ¹² DOID:0110850

ICD10 ³³ Q82.1

MedGen ⁴² C0268136 C1970808

MeSH ⁴⁴ D014983

UMLS ⁷³ C0268136

Sources

Summaries for Xeroderma Pigmentosum, Complementation Group B

UniProtKB/Swiss-Prot : ⁷⁵ Xeroderma pigmentosum complementation group B: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-B patients present features of Cockayne syndrome, including cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex.

MalaCards based summary : Xeroderma Pigmentosum, Complementation Group B, also known as xeroderma pigmentosum, group b, is related to xeroderma pigmentosum, complementation group a and trichothiodystrophy 1, photosensitive, and has symptoms including ataxia An important gene associated with Xeroderma Pigmentosum, Complementation Group B is ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit), and among its related pathways/superpathways are HIV Transcription Elongation and DNA Double-Strand Break Repair. The drugs Baclofen and Arbaclofen placarbil have been mentioned in the context of this disorder. Affiliated tissues include skin and spinal cord, and related phenotypes are intellectual disability and ataxia

Disease Ontology : ¹² A xeroderma pigmentosum characterized by that has material basis in mutation in the ERCC3 gene on chromosome 2q14.

OMIM : ⁵⁷ For a general discussion of xeroderma pigmentosum, see XPA (278700), and of Cockayne syndrome, see CSA (216400). Cleaver (1990) provided a review of the causes of xeroderma pigmentosum. (610651)

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Related Diseases for Xeroderma Pigmentosum, Complementation Group B

Diseases in the Xeroderma Pigmentosum, Complementation Group a family:

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Complementation Group B

Diseases related to Xeroderma Pigmentosum, Complementation Group B via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)

#	Related Disease	Score	Top Affiliating Genes
1	xeroderma pigmentosum, complementation group a	31.8	ERCC1 XPA
2	trichothiodystrophy 1, photosensitive	28.8	ERCC1 ERCC2 ERCC3 GTF2H4 GTF2H5 XPA
3	xeroderma pigmentosum, variant type	28.2	ERCC1 ERCC2 ERCC3 RAD23B XPA
4	ovarian cancer	10.1
5	xeroderma pigmentosum, complementation group c	9.8	ERCC3 RAD23B XPA
6	cockayne syndrome b	9.7	ERCC2 XPA
7	xeroderma pigmentosum group e	9.7	ERCC1 RAD23B XPA
8	cerebro-oculo-facio-skeletal syndrome	9.5	ERCC1 ERCC2 ERCC3
9	xeroderma pigmentosum, complementation group g	9.5	ERCC1 ERCC3 RAD23B XPA
10	diffuse gastric cancer	9.5	ERCC1 ERCC2
11	autosomal genetic disease	9.4	ERCC1 ERCC2 XPA
12	uv-sensitive syndrome	9.3	ERCC2 ERCC3
13	basal cell carcinoma	9.2	ERCC1 ERCC2 XPA
14	mutagen sensitivity	9.1	ERCC2 RAD23B XPA
15	xeroderma pigmentosum, complementation group f	8.8	ERCC1 ERCC2 RAD23B XPA
16	autosomal recessive disease	8.8	ERCC1 ERCC2 ERCC3 GTF2H5 XPA
17	cockayne syndrome	8.6	ERCC1 ERCC2 ERCC3 GTF2H1 XPA
18	xeroderma pigmentosum, complementation group d	8.1	ERCC1 ERCC2 ERCC3 GTF2H5 RAD23B XPA

Graphical network of the top 20 diseases related to Xeroderma Pigmentosum, Complementation Group B:

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Symptoms & Phenotypes for Xeroderma Pigmentosum, Complementation Group B

Symptoms via clinical synopsis from OMIM:

⁵⁷

Neurologic Central Nervous System:
ataxia
cerebellar atrophy
abnormal myelination
mental retardation
basal ganglia calcifications
more

Head And Neck Head:
microcephaly

Growth Height:
short stature

Endocrine Features:
hypogonadism

Head And Neck Ears:
sensorineural deafness

Laboratory Abnormalities:
increased cellular sensitivity to uv light
decreased dna excision repair

Neurologic Peripheral Nervous System:
hyperreflexia
decreased nerve conduction velocity

Head And Neck Eyes:
optic atrophy
microphthalmia
pigmentary retinopathy
cataracts

Neoplasia:
melanoma
squamous cell carcinoma
basal cell carcinoma
increased risk of malignancy

Skin Nails Hair Skin:
freckling
atrophic skin
photosensitivity
abnormal pigmentation

Head And Neck Face:
wizened face

Growth Weight:
cachectic appearance

Clinical features from OMIM:

610651

Human phenotypes related to Xeroderma Pigmentosum, Complementation Group B:

³² (show all 24)

#	Description	HPO Source Accession
1	intellectual disability ³²	HP:0001249
2	ataxia ³²	HP:0001251
3	hyperreflexia ³²	HP:0001347
4	cataract ³²	HP:0000518
5	microcephaly ³²	HP:0000252
6	sensorineural hearing impairment ³²	HP:0000407
7	optic atrophy ³²	HP:0000648
8	short stature ³²	HP:0004322
9	decreased nerve conduction velocity ³²	HP:0000762
10	ventriculomegaly ³²	HP:0002119
11	hypogonadism ³²	HP:0000135
12	microphthalmia ³²	HP:0000568
13	cutaneous photosensitivity ³²	HP:0000992
14	cerebellar atrophy ³²	HP:0001272
15	cutaneous melanoma ³²	HP:0012056
16	squamous cell carcinoma of the skin ³²	HP:0006739
17	freckling ³²	HP:0001480
18	pigmentary retinopathy ³²	HP:0000580
19	progeroid facial appearance ³²	HP:0005328
20	dermal atrophy ³²	HP:0004334
21	basal cell carcinoma ³²	HP:0002671
22	abnormal cns myelination ³²	HP:0011400
23	basal ganglia calcification ³²	HP:0002135
24	increased cellular sensitivity to uv light ³²	HP:0003224

UMLS symptoms related to Xeroderma Pigmentosum, Complementation Group B:

ataxia

GenomeRNAi Phenotypes related to Xeroderma Pigmentosum, Complementation Group B according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.23	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5

MGI Mouse Phenotypes related to Xeroderma Pigmentosum, Complementation Group B:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system	MP:0005389	9.1	ERCC1 ERCC2 ERCC3 HELB RAD23B XPA

Sources

Drugs & Therapeutics for Xeroderma Pigmentosum, Complementation Group B

Drugs for Xeroderma Pigmentosum, Complementation Group B (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Baclofen

Approved

Phase 3,Phase 2

1134-47-0

2284

Synonyms:

( inverted question mark)-Baclofen

(?)-Baclofen

(+-)-Baclofen

(+/-)- beta-(Aminoethyl)-4- chlorobenzenepropanoic acid

(+/-)-BACLOFEN

(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

1134-47-0

4-Amino-3-(4-chlorophenyl)butanoic acid

4-amino-3-(4-Chlorophenyl)butyrate

4-amino-3-(4-Chlorophenyl)butyric acid

4-Amino-3-(4-chlorophenyl)butyric acid

62594-36-9

AB00051921

AC1L1DC6

AC-4530

Alphapharm brand OF baclofen

Alphapharm Brand of Baclofen

apo Baclofen

Apo Baclofen

apo-Baclofen

ApoBaclofen

Apo-Baclofen

Apotex brand OF baclofen

Apotex Brand of Baclofen

Ashbourne brand OF baclofen

Ashbourne Brand of Baclofen

ASTA medica brand OF baclofen

ASTA Medica Brand of Baclofen

Athena brand OF baclofen

Athena Brand of Baclofen

Atrofen

AWD, baclofen

AWD, Baclofen

B 5399

b-(4-Chlorophenyl)gaba

b-(Aminomethyl)-4-chlorobenzenepropanoate

b-(Aminomethyl)-4-chlorobenzenepropanoic acid

b-(Aminomethyl)-P-chlorohydrocinnamate

b-(Aminomethyl)-P-chlorohydrocinnamic acid

b-(P-Chlorophenyl)-g-aminobutyrate

b-(P-Chlorophenyl)-g-aminobutyric acid

B3343

B5399_SIGMA

Ba 34647

Ba34,647

Ba-34,647

Ba34647

Ba-34647

baclofen

Baclofen (JP15/USP/INN)

Baclofen (R,S)

Baclofen [USAN:INN:BAN:JAN]

Baclofen alphapharm brand

Baclofen Alphapharm Brand

Baclofen apotex brand

Baclofen Apotex Brand

Baclofen ashbourne brand

Baclofen Ashbourne Brand

Baclofen athena brand

Baclofen Athena Brand

Baclofen awd

Baclofen AWD

Baclofen ciba-geigy brand

Baclofen Ciba-Geigy Brand

Baclofen irex brand

Baclofen Irex Brand

Baclofen isis brand

Baclofen Isis Brand

Baclofen medtronic brand

Baclofen Medtronic Brand

Baclofen novartis brand

Baclofen Novartis Brand

Baclofen nu-pharm brand

Baclofen Nu-Pharm Brand

Baclofen pharmascience brand

Baclofen Pharmascience Brand

Baclofene

Baclofene [INN-French]

Baclofene Irex

Baclofène irex

BaclofeneIrex

Baclofene-Irex

Baclofène-irex

BaclofèneIrex

Baclofeno

Baclofeno [INN-Spanish]

Baclofenum

Baclofenum [INN-Latin]

Baclon

Baclophen

Baclospas

Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-(9CI)

beta-(4-Chlorophenyl)gaba

beta-(Aminomethyl)-4-chlorobenzenepropanoate

beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

beta-(Aminomethyl)-P-chlorohydrocinnamate

beta-(Aminomethyl)-p-chlorohydrocinnamic acid

beta-(Aminomethyl)-P-chlorohydrocinnamic acid

beta-(P-Chlorophenyl)-gamma-aminobutyrate

beta-(p-Chlorophenyl)-gamma-aminobutyric acid

beta-(P-Chlorophenyl)-gamma-aminobutyric acid

Biomol-NT_000251

BPBio1_000012

BPBio1_000750

BRD-A84174873-001-05-2

BRN 2104494

BSPBio_000010

BSPBio_001880

C 34647Ba

C10H12ClNO2

CCRIS 3722

CHEBI:2972

CHEMBL701

Chlorophenyl gaba

Chlorophenyl GABA

Ciba 34,647-Ba

Ciba geigy brand OF baclofen

Ciba Geigy Brand of Baclofen

CIBA34,647ba

CIBA-34,647-ba

CIBA34,647BA

CIBA-34,647-BA

Ciba-geigy brand OF baclofen

Ciba-Geigy Brand of Baclofen

CID2284

Clofen

D001418

D00241

DB00181

DivK1c_000001

DL-4-amino-3-P-Chlorophenylbutanoate

DL-4-amino-3-P-Chlorophenylbutanoic acid

DL-4-Amino-3-p-chlorophenylbutanoic acid

DL-4-Amino-3-P-chlorophenylbutanoic acid

DL-Baclofen

EINECS 214-486-9

EU-0100163

GABA, chlorophenyl

GABA, Chlorophenyl

Gabalon

g-amino-b-(P-Chlorophenyl)butyrate

g-amino-b-(P-Chlorophenyl)butyric acid

gamma-amino-beta-(P-Chlorophenyl)butyrate

gamma-amino-beta-(P-Chlorophenyl)butyric acid

gamma-Amino-beta-(p-chlorophenyl)butyric acid

gamma-Amino-beta-(P-chlorophenyl)butyric acid

Gen baclofen

Gen Baclofen

Gen-baclofen

GenBaclofen

Gen-Baclofen

Genpharm

HMS1568A12

HMS1920E21

HMS2091M03

HMS500A03

I01-1934

IDI1_000001

Irex brand OF baclofen

Irex Brand of Baclofen

Isis brand OF baclofen

Isis Brand of Baclofen

KBio1_000001

KBio2_000466

KBio2_003034

KBio2_005602

KBio3_001380

KBioGR_000650

KBioSS_000466

Kemstro

Kemstro (TN)

L000002

Lebic

Lioresal

Liorésal

Lioresal (TN)

Lioresal Intrathecal

Lopac0_000163

LS-77134

Medtronic brand OF baclofen

Medtronic Brand of Baclofen

MLS000028480

MolPort-002-051-370

NCGC00015156-05

NCGC00015156-12

NCGC00023843-03

NCGC00024579-03

NCGC00024579-04

NCGC00024579-05

NCGC00024579-06

NINDS_000001

Novartis brand OF baclofen

Novartis Brand of Baclofen

NSC329137

Nu baclo

Nu Baclo

Nu pharm brand OF baclofen

Nu Pharm Brand of Baclofen

Nu-baclo

NuBaclo

Nu-Baclo

Nu-Baclofen

Nu-pharm brand OF baclofen

Nu-Pharm Brand of Baclofen

Oprea1_440627

PCP-GABA

Pharmascience brand OF baclofen

Pharmascience Brand of Baclofen

PMS Baclofen

Pms-Baclofen

PMSBaclofen

PMS-Baclofen

Prestwick_85

Prestwick0_000085

Prestwick1_000085

Prestwick2_000085

Prestwick3_000085

SMP1_000036

SMR000058294

SPBio_000044

SPBio_001949

Spectrum_000066

SPECTRUM1500135

Spectrum2_000092

Spectrum3_000310

Spectrum4_000245

Spectrum5_000852

STK535284

STOCK2S-30552

UNII-H789N3FKE8

UPCMLD-DP142

UPCMLD-DP142:001

β-(4-chlorophenyl)gaba

β-(aminomethyl)-4-chlorobenzenepropanoate

β-(aminomethyl)-4-chlorobenzenepropanoic acid

β-(aminomethyl)-P-chlorohydrocinnamate

β-(aminomethyl)-P-chlorohydrocinnamic acid

β-(P-chlorophenyl)-γ-aminobutyrate

β-(P-chlorophenyl)-γ-aminobutyric acid

γ-amino-β-(P-chlorophenyl)butyrate

γ-amino-β-(P-chlorophenyl)butyric acid

2

Arbaclofen placarbil

Investigational

Phase 3,Phase 2

847353-30-4

3

GABA Agents

Phase 3,Phase 2

4

GABA Agonists

Phase 3,Phase 2

5

GABA-B Receptor Agonists

Phase 3,Phase 2

6

Neuromuscular Agents

Phase 3,Phase 2

7

Neurotransmitter Agents

Phase 3,Phase 2

8

Peripheral Nervous System Agents

Phase 3,Phase 2

9

Dexlansoprazole

Approved, Investigational

Phase 2

138530-94-6, 103577-45-3

9578005

Synonyms:

138530-94-6

2-((R)-((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole

CHEMBL1201863

CID9578005

D08903

dexlansoprazole

Dexlansoprazole (INN/USAN)

Kapidex

KS-1075

MolPort-002-885-834

T 168390

TAK 390

UNII-UYE4T5I70X

ZINC00599734

10

Esomeprazole

Approved, Investigational

Phase 2

161796-78-7, 119141-88-7

4594 9579578

Synonyms:

( -)-Omeprazole

(-)-omeprazole

(−)-omeprazole

(-)-Omeprazole

(S)-(−)-omeprazole

(S)-(-)-Omeprazole

(S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

(S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

(s)-omeprazole

(S)-omeprazole

(S)-Omeprazole

119141-88-7

119141-89-8

131959-78-9

172964-80-6

193469-77-1

2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole

2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole

326602-80-6

5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole

5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole

5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1-methyl-1H-benzimidazole

6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

73590-58-6

AC1L1IIJ

AC-401

AGI-010

AKOS005066653

Alenia

Antra

Antra MUPS

AstraZeneca brand OF esomeprazole magnesium

Audazol

AULCER

Axagon

Belmazol

BIDD:GT0020

BIDD:GT0189

Bio-0888

BPBio1_000425

BRD-A55962179-001-04-9

BSPBio_000385

C07324

CAS-73590-58-6

CCRIS 7099

Ceprandal

CHEBI:50275

CHEBI:519601

CHEBI:7772

CHEMBL1503

CID4594

CID9568614

CID9579578

CPD000058847

D00455

D07917

Danlox

DB00338

DB00736

Demeprazol

Desec

Dizprazol

DM-3458

Dudencer

Elgam

Emeproton

Emilok

Epirazole

Erbolin

Escz

Esofag

esomeprazol

Esomeprazol

esomeprazole

Esomeprazole

Ésoméprazole

Esomeprazole (INN)

Esomeprazole [INN:BAN]

Esomeprazole magnesium

Esomeprazole potassium

Esomeprazole sodium

Esomeprazole Sodium

Esomeprazole strontium

Esomeprazole strontium anhydrous

esomeprazolum

Esomeprazolum

Esomperazole

Esopral

Exter

Gasec

Gastrimut

Gastroloc

Gibancer

H 168/68

H 168-68

H168/68

H-168/68

HMS1528I05

HMS1569D07

HMS2052G17

HMS2090E16

HMS2090F11

HSDB 3575

I06-0705

IDI1_032523

InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20

Indurgan

Inexium paranova

Inexium paranova (TN)

Inhibitron

Inhipump

Lensor

Logastric

Lomac

Losec

Losec, Omesec, Prilosec, Zegerid, Omeprazole

LS-185188

LS-7629

Lucen

Maybridge4_002645

Mepral

Miol

Miracid

MLS000069373

MLS001076112

MLS001424148

MolPort-003-666-741

MolPort-003-807-515

MolPort-003-849-702

MolPort-005-943-880

Mopral

Morecon

NCGC00016925-01

NCGC00016925-02

NCGC00021522-03

NCGC00021522-04

NCGC00021522-05

Nexiam

Nexium

Nexium Control

Nexium IV

Nilsec

Nopramin

Nuclosina

O0359

O104_SIGMA

Ocid

Olexin

Olit

Omapren

Omebeta

Omebeta 20

Omed

Omegast

OMEP

Omepradex

Omepral

Omeprazol

Omeprazol [INN-Spanish]

omeprazole

Omeprazole (JAN/USP/INN)

Omeprazole [USAN:INN:BAN:JAN]

Omeprazole delayed-release

Omeprazole magnesium

Omeprazole S-form

Omeprazolum

Omeprazolum [INN-Latin]

Omeprazon

Omeprazone

Omeprol

Omesek

Omez

Omezol

Omezolan

Omid

Omisec

Omizac

Ompanyt

OMZ

Ortanol

Osiren

Ozoken

Paprazol

Parizac

Pepticum

Pepticus

Peptilcer

Perprazole

Prazentol

Prazidec

Prazolit

Prestwick_808

Prestwick0_000493

Prestwick1_000493

Prestwick2_000493

Prestwick3_000493

Prilosec

Prilosec (TN)

Prilosec OTC

Procelac

Proclor

Prysma

Ramezol

Regulacid

Result

S1389_Selleck

SAM001246900

SAN-15

Sanamidol

Secrepina

SMR000058847

SPBio_002306

STK623746

Strontium, esomeprazole

Tedec Ulceral

TL8005099

Ulceral

Ulcesep

Ulcometion

Ulcozol

Ulcsep

Ulsen

Ultop

Ulzol

UNII-KG60484QX9

UNII-N3PA6559FT

UPCMLD-DP075

UPCMLD-DP075:001

Victrix

Zefxon

Zegerid

Zepral

Zimor

ZINC04693574

ZINC04693575

Zoltum

11

Lansoprazole

Approved, Investigational

Phase 2

103577-45-3

3883

Synonyms:

103577-45-3

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole

2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)-1H-benzimidazole

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole

2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole

2-[({3-methyl-4-[(2,2,2-trifluoroethyl)oxy]pyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole

2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole

2-[[[3-methyl-4-(2,2,2-trifluroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole

2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole

A 65006

A-65006

AB00052388

Abbot brand OF lansoprazole

Abbot Brand of Lansoprazole

ABT-006

AC1L1GX8

AG 1749

AG-1749

Agopton

Almirall brand OF lansoprazole

Almirall Brand of Lansoprazole

Amarin

Aprazol

Bamalite

BIDD:GT0006

Bio-0824

Biuret

Biuret Gr

Biuret Reagent

Biuret Reagent Solution

Blason

BPBio1_001194

BRD-A49172652-001-05-7

BRN 4333393

BSPBio_001084

BSPBio_001830

C058687

C16H14F3N3O2S

CAS-103577-45-3

CG-4801

CHEBI:6375

CHEMBL480

CID3883

Compraz

CPD000058469

D00355

Dakar

DB00448

DivK1c_000920

EU-0100709

FT-0082011

HMS1571G06

HMS1922M04

HMS2052F05

HMS2093M07

HMS502N22

Hoechst brand OF lansoprazole

Hoechst Brand of Lansoprazole

Hormona brand OF lansoprazole

Hormona Brand of Lansoprazole

HSDB 7204

I06-0018

IDI1_000920

Ilsatec

KBio1_000920

KBio2_002060

KBio2_004628

KBio2_007196

KBio3_001330

KBioGR_001491

KBioSS_002060

Ketian

L 8533

L8533_SIGMA

Lancid

Lanfast

Lanproton

Lansol

Lansopep

Lansophed

Lansoprazol

Lansoprazol [INN-Spanish]

lansoprazole

Lansoprazole

Lansoprazole (JAN/USP/INN)

Lansoprazole [Usan:Ban:Inn]

Lansoprazole [USAN:BAN:INN]

Lansoprazole abbot brand

Lansoprazole almirall brand

Lansoprazole hoechst brand

Lansoprazole hormona brand

Lansoprazole lederle brand

Lansoprazole promeco brand

Lansoprazole salvar brand

Lansoprazole sodium

lansoprazole sulphone

Lansoprazole takeda brand

Lansoprazole tap brand

Lansoprazole tecnobio brand

Lansoprazole vinas brand

Lansoprazole wyeth brand

Lansoprazoles

Lansoprazolum

Lansoprazolum [INN-Latin]

Lansox

Lanston

Lanz

Lanzo

Lanzol

Lanzol-30

Lanzopral

lanzoprazole

Lanzor

Lanzul

Lapraz

Lasoprol

Lederle brand OF lansoprazole

Lederle Brand of Lansoprazole

Limpidex

Linamarin

Lopac0_000709

Lopac-L-8533

LS-33080

Mesactol

MLS000069705

MLS-0003247.0001

MLS000759405

MLS001074170

MolPort-003-666-508

MolPort-006-394-760

Monolitum

NCGC00015615-01

NCGC00015615-02

NCGC00015615-03

NCGC00015615-06

NCGC00015615-11

NCGC00023826-03

NCGC00023826-04

NCGC00023826-05

NCGC00023826-06

NCGC00023826-07

NINDS_000920

Ogast

Ogastro

Opiren

Prestwick0_001072

Prestwick1_001072

Prestwick2_001072

Prestwick3_001072

Prevacid

Prevacid (TN)

Prevacid I.V

Prevacid I.V.

Prevacid Iv

Prevacid Solutab

Prevacid SoluTab

Prevacid, Prevacid NapraPAC, Prevacid SoluTab, Lansoprazole

PrevOnco

Prevpac

Prezal

pro Ulco

Pro Ulco

Promeco

promeco Brand OF lansoprazole

Promeco Brand of Lansoprazole

Promp

Prosogan

S1354_Selleck

Salvar brand OF lansoprazole

Salvar Brand of Lansoprazole

SAM001246544

SMR000058469

Sodium, lansoprazole

SPBio_000488

SPBio_002992

Spectrum_001580

SPECTRUM1503926

Spectrum2_000444

Spectrum3_000295

Spectrum4_000856

Spectrum5_001521

STK621169

Suprecid

TAK 390MR

TAK390MR

TAK-390MR

Takeda brand OF lansoprazole

Takeda Brand of Lansoprazole

Takepron

TAP brand OF lansoprazole

TAP Brand of Lansoprazole

tecnobio Brand OF lansoprazole

Tecnobio Brand of Lansoprazole

TL8000155

Ulpax

UNII-0K5C5T2QPG

Vinas brand OF lansoprazole

Vinas Brand of Lansoprazole

Wyeth brand OF lansoprazole

Wyeth Brand of Lansoprazole

Zoprol

Zoton

12

Omeprazole

Approved, Investigational, Vet_approved

Phase 2

73590-58-6

4594

Synonyms:

( -)-Omeprazole

(-)-Omeprazole

(S)-(-)-Omeprazole

(S)-Omeprazole

119141-89-8

131959-78-9

172964-80-6

2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole

2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole

2,3,5-Trimethylpyridine/Omeprazole

5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole

5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

73590-58-6

AC1L1IIJ

AC-401

AGI-010

AKOS005066653

Antra

Antra mups

Antra MUPS

Audazol

Aulcer

AULCER

Axagon

Belmazol

BIDD:GT0189

Bio-0888

BPBio1_000425

BRD-A55962179-001-04-9

BSPBio_000385

C07324

CAS-73590-58-6

CCRIS 7099

Ceprandal

CHEBI:519601

CHEBI:7772

CHEMBL1503

CID4594

CPD000058847

D00455

Danlox

DB00338

DB00736

Demeprazol

Desec

Dizprazol

DM-3458

Dudencer

Elgam

Emeproton

Emilok

Epirazole

Erbolin

esomeprazol

Esomeprazole

Esomperazole

Esopral

Exter

Gasec

Gastrimut

Gastroloc

Gibancer

H 168/68

H 168-68

H168/68

H-168/68

HMS1528I05

HMS1569D07

HMS2052G17

HMS2090E16

HMS2090F11

HSDB 3575

I06-0705

IDI1_032523

Indurgan

Inhibitron

Inhipump

Lensor

Logastric

Lomac

Losec

Losec, Omesec, Prilosec, Zegerid, Omeprazole

LS-7629

Lucen

Magnesium, omeprazole

Maybridge4_002645

Mepral

Miol

Miracid

MLS000069373

MLS001076112

MLS001424148

MolPort-003-666-741

MolPort-003-807-515

MolPort-003-849-702

Mopral

Morecon

NCGC00016925-01

NCGC00016925-02

NCGC00021522-03

NCGC00021522-04

NCGC00021522-05

Nexiam

Nexium

Nexium IV

Nilsec

Nopramin

Nuclosina

O0359

O104_SIGMA

Ocid

Olexin

Olit

Omapren

Omebeta

Omebeta 20

Omed

Omegast

OMEP

Omepradex

Omepral

Omeprazol

Omeprazol [INN-Spanish]

omeprazole

Omeprazole (JAN/USP/INN)

Omeprazole [USAN:INN:BAN:JAN]

Omeprazole delayed-release

Omeprazole magnesium

Omeprazole pellets

Omeprazole sodium

Omeprazolum

Omeprazolum [INN-Latin]

Omeprazon

Omeprazone

Omeprol

Omesek

Omez

Omezol

Omezolan

Omid

Omisec

Omizac

OMP

Ompanyt

OMZ

Ortanol

Osiren

Ozoken

Paprazol

Parizac

Pepticum

Pepticus

Peptilcer

Prazentol

Prazidec

Prazolit

Prestwick_808

Prestwick0_000493

Prestwick1_000493

Prestwick2_000493

Prestwick3_000493

Prilosec

Prilosec (TN)

Prilosec otc

Prilosec OTC

Procelac

Proclor

Prysma

Ramezol

Regulacid

Result

S1389_Selleck

SAM001246900

SAN-15

Sanamidol

Secrepina

SMR000058847

Sodium, omeprazole

SPBio_002306

STK623746

Tedec ulceral

Tedec Ulceral

TL8005099

Ulceral

Ulcesep

Ulcometion

Ulcozol

Ulcsep

Ulsen

Ultop

Ulzol

UNII-KG60484QX9

UPCMLD-DP075

UPCMLD-DP075:001

Victrix

Zefxon

Zegerid

Zepral

Zimor

Zoltum

13

Pantoprazole

Approved

Phase 2

102625-70-7

4679

Synonyms:

102625-70-7

5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole

5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole

AC1L1IPJ

AC-679

Astropan

BIDD:GT0003

BRD-A22380646-001-01-5

BSPBio_002320

BY 1023

BY-1023

C11806

C16H15F2N3O4S

CHEBI:519598

CHEBI:7915

CHEMBL1502

CID4679

D05353

DB00213

HMS1922H20

HMS2090H03

HMS2093F14

HSDB 7292

I06-0068

LS-32883

MolPort-003-666-752

MolPort-005-933-577

NCGC00095188-01

NCGC00095188-02

NCGC00095188-03

Pantoloc

Pantopan

Pantoprazol

Pantoprazol [INN-Spanish]

pantoprazole

Pantoprazole (USAN/INN)

Pantoprazole [USAN:BAN:INN]

Pantoprazole Na

Pantoprazole sodium

Pantoprazole Sodium

Pantoprazole sodium hydrate

Pantoprazolum

Pantoprazolum [INN-Latin]

Pantoprozole

Pantor

Pantozol

Protium

Protonix

Protonix i.v.

Protonix I.V.

Protonix IV

SBB070993

SK And F 96022

SK And F-96022

SK&F 96022

SK&F-96022

SK-96022

SKF-96022

Somac

SPECTRUM1505818

TL8000127

UNII-D8TST4O562

14

Rabeprazole

Approved, Investigational

Phase 2

117976-89-3

5029

Synonyms:

117976-89-3

1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, sodium salt

2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole

2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole

2-((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole

2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole

2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole

AC1L1JGC

Aciphex

AcipHex

BIDD:GT0019

C063129

C07864

C18H21N3O3S

CHEBI:8768

CHEMBL1219

CID5029

CL23619

Clofezone

CPD000469174

D08463

DB01129

dexrabeprazole

Dexrabeprazole

Eraloc

Eraloc (TN)

Habeprazole

HMS2052P03

HSDB 7321

I06-0755

Irsogladine Maleate

LS-172365

LY307640

MLS001401446

MolPort-005-935-061

Pariet

Pariets

rabeprazole

Rabeprazole

Rabeprazole (INN)

Rabeprazole [BAN:INN]

Rabeprazole [INN:BAN]

rabeprazole sodium

Rabeprazole sodium

Rebeprazole sodium

SAM001246619

SMR000469174

Sodium rabeprazole

Sodium, rabeprazole

UNII-32828355LL

15

Antacids

Phase 2

16

Anti-Ulcer Agents

Phase 2

17

Gastrointestinal Agents

Phase 2

18

Proton Pump Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy and Safety of Arbaclofen Placarbil in Subjects With Spasticity Due to Multiple Sclerosis	Completed	NCT01359566	Phase 3	Arbaclofen placarbil 15 mg BID;Placebo;Arbaclofen placarbil 30 mg BID;Arbaclofen placarbil 45 mg BID
2	A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)	Completed	NCT00978016	Phase 2	arbaclofen placarbil-Cohort 1;Placebo-Cohort 5;arbaclofen placarbil-Cohort 2;arbaclofen placarbil-Cohort 3;arbaclofen placarbil-Cohort 4;PPI
3	A Study to Evaluate the Efficacy and Safety of Controlled Release Arbaclofen Placarbil (XP19986) in Patients With Gastroesophageal Reflux Disease	Completed	NCT00838396	Phase 2	XP19986 CR;Placebo for XP19986 CR
4	A Study to Evaluate the Safety and Tolerability of Arbaclofen Placarbil (XP19986) in Subjects With Acute Back Spasms	Completed	NCT00817986	Phase 2	Arbaclofen placarbil, 20 mg;Placebo;Arbaclofen placarbil, 30 mg;Arbaclofen placarbil, 40 mg
5	A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury	Completed	NCT00557973	Phase 2	XP19986 SR1, 10 mg BID;XP19986 SR1, 20 mg BID;XP19986 SR1, 30 mg BID;Placebo
6	An Efficacy and Safety Study of XP19986 in Subjects With Symptomatic GERD	Completed	NCT00557401	Phase 2	XP19986 SR3, 20 mg QD;XP19986 SR3, 40 mg QD;XP19986 SR3, 60 mg QD;XP19986 SR3, 30 mg BID;Placebo

Search NIH Clinical Center for Xeroderma Pigmentosum, Complementation Group B

Sources

Genetic Tests for Xeroderma Pigmentosum, Complementation Group B

Genetic tests related to Xeroderma Pigmentosum, Complementation Group B:

#	Genetic test	Affiliating Genes
1	Xeroderma Pigmentosum, Complementation Group B ²⁹	ERCC3

Sources

Anatomical Context for Xeroderma Pigmentosum, Complementation Group B

MalaCards organs/tissues related to Xeroderma Pigmentosum, Complementation Group B:

⁴¹

Skin, Spinal Cord

Sources

Publications for Xeroderma Pigmentosum, Complementation Group B

Articles related to Xeroderma Pigmentosum, Complementation Group B:

#	Title	Authors	Year
1	Increased mRNA levels of xeroderma pigmentosum complementation group B (XPB) and Cockayne's syndrome complementation group B (CSB) without increased mRNA levels of multidrug-resistance gene (MDR1) or metallothionein-II (MT-II) in platinum-resistant human ovarian cancer tissues. ( 11077043 )	Dabholkar M....Reed E.	2000
2	Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking. ( 11027286 )	Douziech M....Coulombe B.	2000
3	Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3. ( 1454518 )	Koken M.H....Pastink A.	1992

Sources

Genes for Xeroderma Pigmentosum, Complementation Group B

Genes related to Xeroderma Pigmentosum, Complementation Group B (1 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	1359.05	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷⁵ Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Variants (show sections)	2167179 4811796 8663148 (more) 16947863 20301571 8304337 8408834
2	PUF60	Poly(U) Binding Splicing Factor 60	Protein Coding	34.69	DISEASES inferred ¹⁵ GeneCards inferred via : Proteins Functions (show sections)
3	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	25.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	25.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MT2A	Metallothionein 2A	Protein Coding	21.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	18.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	17.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	17.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	HELB	DNA Helicase B	Protein Coding	17.54	GeneCards inferred via : Publications (show sections)
10	RAD23B	RAD23 Homolog B, Nucleotide Excision Repair Protein	Protein Coding	17.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	16.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	IMMT	Inner Membrane Mitochondrial Protein	Protein Coding	16.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Xeroderma Pigmentosum, Complementation Group B

UniProtKB/Swiss-Prot genetic disease variations for Xeroderma Pigmentosum, Complementation Group B:

⁷⁵

#	Symbol	AA change	Variation ID	SNP ID
1	ERCC3	p.Phe99Ser	VAR_003632	rs121913045

ClinVar genetic disease variations for Xeroderma Pigmentosum, Complementation Group B:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	ERCC3	ERCC3, IVS14AS, C-A, -6	single nucleotide variant	Pathogenic
2	ERCC3	NM_000122.1(ERCC3): c.296T> C (p.Phe99Ser)	single nucleotide variant	Pathogenic	rs121913045	GRCh37	Chromosome 2, 128050361: 128050361
3	ERCC3	NM_000122.1(ERCC3): c.296T> C (p.Phe99Ser)	single nucleotide variant	Pathogenic	rs121913045	GRCh38	Chromosome 2, 127292785: 127292785
4	ERCC3	NM_000122.1(ERCC3): c.1273C> T (p.Arg425Ter)	single nucleotide variant	Pathogenic	rs121913047	GRCh37	Chromosome 2, 128044348: 128044348
5	ERCC3	NM_000122.1(ERCC3): c.1273C> T (p.Arg425Ter)	single nucleotide variant	Pathogenic	rs121913047	GRCh38	Chromosome 2, 127286772: 127286772
6	ERCC3	ERCC3, 2-BP DEL, 807TT	deletion	Pathogenic
7	ERCC3	ERCC3, 1-BP INS, 1421A	insertion	Pathogenic
8	ERCC3	NM_000122.1(ERCC3): c.1633C> T (p.Gln545Ter)	single nucleotide variant	Pathogenic	rs121913048	GRCh37	Chromosome 2, 128036846: 128036846
9	ERCC3	NM_000122.1(ERCC3): c.1633C> T (p.Gln545Ter)	single nucleotide variant	Pathogenic	rs121913048	GRCh38	Chromosome 2, 127279270: 127279270
10	ERCC3	ERCC3, IVS3DS, G-A, +1	single nucleotide variant	Pathogenic

Sources

Expression for Xeroderma Pigmentosum, Complementation Group B

Search GEO for disease gene expression data for Xeroderma Pigmentosum, Complementation Group B.

Sources

Pathways for Xeroderma Pigmentosum, Complementation Group B

Pathways related to Xeroderma Pigmentosum, Complementation Group B according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	HIV Transcription Elongation ⁶⁶ Show member pathways Abortive elongation of HIV-1 transcript in the absence of Tat ⁶⁶ FGFR2 alternative splicing ⁶⁶ Formation of HIV elongation complex in the absence of HIV Tat ⁶⁶ Formation of HIV-1 elongation complex containing HIV-1 Tat ⁶⁶ Formation of RNA Pol II elongation complex ⁶⁶ Formation of the Early Elongation Complex ⁶⁶ Formation of the HIV-1 Early Elongation Complex ⁶⁶ HIV elongation arrest and recovery ⁶⁶ MicroRNA (miRNA) biogenesis ⁶⁶ miRNA Biogenesis ¹ mRNA Capping ⁶⁶ Pausing and recovery of HIV elongation ⁶⁶ Pausing and recovery of Tat-mediated HIV elongation ⁶⁶ RNA Pol II CTD phosphorylation and interaction with CE ⁶⁶ RNA Pol II CTD phosphorylation and interaction with CE during HIV infection ⁶⁶ RNA Polymerase II Pre-transcription Events ⁶⁶ RNA polymerase II transcribes snRNA genes ⁶⁶ RNA Polymerase II Transcription ⁶⁶ RNA Polymerase II Transcription Elongation ⁶⁶ Tat-mediated elongation of the HIV-1 transcript ⁶⁶ Tat-mediated HIV elongation arrest and recovery ⁶⁶ TP53 Regulates Transcription of DNA Repair Genes ⁶⁶ Transcription of the HIV genome ⁶⁶	12.97	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
2	DNA Double-Strand Break Repair ⁶⁶ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁶ DNA damage_DNA-damage-induced responses ²² DNA Repair ⁶⁶ G2/M DNA damage checkpoint ⁶⁶ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁶ HDR through MMEJ (alt-NHEJ) ⁶⁶ Homology Directed Repair ⁶⁶ Non-homologous end joining ¹ Non-homologous end-joining ³⁷ Processing of DNA double-strand break ends ⁶⁶	12.97	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
3	RNA Polymerase II Transcription Initiation And Promoter Clearance ⁶⁶ Show member pathways Assembly of RNA Polymerase-II Initiation Complex ⁶⁴ Basal transcription factors ³⁷ Crosstalk Between CARM1 and ESRs ⁶⁴ Eukaryotic Transcription Initiation ¹ HIV Transcription Initiation ⁶⁶ Protein Acetylation and Deacetylation ⁶⁴ RNA Polymerase II HIV Promoter Escape ⁶⁶ RNA Polymerase II Promoter Escape ⁶⁶ RNA Polymerase II Transcription Initiation ⁶⁶ RNA Polymerase II Transcription Pre-Initiation And Promoter Opening ⁶⁶ Transcription Ligand-Dependent Transcription of Retinoid-Target genes ²² Transcription of mRNA ⁶⁴	12.74	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
4	Regulation of TP53 Activity ⁶⁶ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁶ Regulation of TP53 Activity through Methylation ⁶⁶ Regulation of TP53 Activity through Phosphorylation ⁶⁶ Transcriptional Regulation by TP53 ⁶⁶	12.67	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
5	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ Parkinson's Disease Pathway ⁶⁴ SREBP Proteolysis ⁶⁴	12.49	ERCC1 ERCC2 ERCC3 GTF2H1 RAD23B XPA
6	Transcription-Coupled Nucleotide Excision Repair (TC-NER) ⁶⁶ Show member pathways DNA Damage Recognition in GG-NER ⁶⁶ Dual incision in TC-NER ⁶⁶ Formation of Incision Complex in GG-NER ⁶⁶ Formation of TC-NER Pre-Incision Complex ⁶⁶ Gap-filling DNA repair synthesis and ligation in TC-NER ⁶⁶ Global Genome Nucleotide Excision Repair (GG-NER) ⁶⁶ Nucleotide Excision Repair ⁶⁶	12.49	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
7	DNA Damage ⁴	12.3	ERCC1 ERCC2 ERCC3 RAD23B XPA
8	SMAD Signaling Network ⁶⁴	11.82	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5 XPA
9	RNA Polymerase I Promoter Escape ⁶⁶ Show member pathways RNA Polymerase I Transcription Initiation ⁶⁶ RNA Polymerase I Transcription Termination ⁶⁶	11.76	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
10	Nucleotide excision repair ³⁷ Show member pathways Dual Incision in GG-NER ⁶⁶ Nucleotide Excision Repair Pathway ⁶⁴	11.29	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
11	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.82	ERCC1 ERCC2 ERCC3 MT2A XPA

Sources

GO Terms for Xeroderma Pigmentosum, Complementation Group B

Cellular components related to Xeroderma Pigmentosum, Complementation Group B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.97	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
2	holo TFIIH complex	GO:0005675	9.46	ERCC2 ERCC3 GTF2H1 GTF2H4
3	DNA replication factor A complex	GO:0005662	9.43	HELB XPA
4	cyclin-dependent protein kinase activating kinase holoenzyme complex	GO:0019907	9.4	ERCC2 PUF60
5	transcription factor TFIID complex	GO:0005669	9.35	ERCC1 ERCC2 ERCC3 GTF2H4 GTF2H5
6	nucleotide-excision repair factor 1 complex	GO:0000110	9.26	ERCC1 XPA
7	core TFIIH complex	GO:0000439	9.02	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
8	nucleus	GO:0005634	10.11	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5

Biological processes related to Xeroderma Pigmentosum, Complementation Group B according to GeneCards Suite gene sharing:

(show all 29)

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription initiation from RNA polymerase II promoter	GO:0006367	9.98	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
2	transcription elongation from RNA polymerase II promoter	GO:0006368	9.97	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
3	7-methylguanosine mRNA capping	GO:0006370	9.95	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
4	transcription initiation from RNA polymerase I promoter	GO:0006361	9.93	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
5	termination of RNA polymerase I transcription	GO:0006363	9.92	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
6	transcription elongation from RNA polymerase I promoter	GO:0006362	9.91	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
7	nucleotide-excision repair, DNA incision	GO:0033683	9.91	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
8	response to oxidative stress	GO:0006979	9.89	ERCC1 ERCC2 ERCC3 XPA
9	embryonic organ development	GO:0048568	9.88	ERCC1 ERCC2 ERCC3 RAD23B
10	nucleotide-excision repair, DNA incision, 5-to lesion	GO:0006296	9.87	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
11	UV protection	GO:0009650	9.86	ERCC1 ERCC2 ERCC3 XPA
12	multicellular organism growth	GO:0035264	9.8	ERCC1 ERCC2 XPA
13	nucleotide-excision repair, DNA incision, 3-to lesion	GO:0006295	9.8	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
14	DNA duplex unwinding	GO:0032508	9.78	ERCC2 GTF2H4 HELB
15	response to UV	GO:0009411	9.77	ERCC2 ERCC3 XPA
16	nucleotide-excision repair, preincision complex assembly	GO:0006294	9.7	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5 RAD23B
17	nucleotide-excision repair, DNA damage recognition	GO:0000715	9.64	RAD23B XPA
18	UV-damage excision repair	GO:0070914	9.64	ERCC1 XPA
19	regulation of mitotic cell cycle phase transition	GO:1901990	9.63	ERCC2 ERCC3
20	hair cell differentiation	GO:0035315	9.62	ERCC2 ERCC3
21	phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	9.61	GTF2H1 GTF2H4
22	nucleotide-excision repair, DNA duplex unwinding	GO:0000717	9.5	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5 RAD23B
23	nucleotide-excision repair, preincision complex stabilization	GO:0006293	9.17	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
24	cellular response to DNA damage stimulus	GO:0006974	10.15	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
25	DNA repair	GO:0006281	10.13	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
26	nucleotide-excision repair	GO:0006289	10.03	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
27	transcription by RNA polymerase II	GO:0006366	10.02	ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
28	global genome nucleotide-excision repair	GO:0070911	10.01	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5
29	transcription-coupled nucleotide-excision repair	GO:0006283	10	ERCC1 ERCC2 ERCC3 GTF2H1 GTF2H4 GTF2H5

Molecular functions related to Xeroderma Pigmentosum, Complementation Group B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase activity	GO:0004672	9.67	ERCC2 ERCC3 GTF2H1 GTF2H4
2	protein C-terminus binding	GO:0008022	9.58	ERCC1 ERCC2 ERCC3
3	damaged DNA binding	GO:0003684	9.56	ERCC1 ERCC3 RAD23B XPA
4	helicase activity	GO:0004386	9.5	ERCC2 ERCC3 HELB
5	DNA-dependent ATPase activity	GO:0008094	9.46	ERCC2 ERCC3 GTF2H1 GTF2H4
6	ATP-dependent DNA helicase activity	GO:0004003	9.26	ERCC2 ERCC3 GTF2H4 HELB
7	RNA polymerase II carboxy-terminal domain kinase activity	GO:0008353	8.92	ERCC2 ERCC3 GTF2H1 GTF2H4

Sources

Sources for Xeroderma Pigmentosum, Complementation Group B

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

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¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia