Aliases & Classifications for Xerophthalmia

MalaCards integrated aliases for Xerophthalmia:

Name: Xerophthalmia 12 76 55 44 15 73
Conjunctival Xerosis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10138
ICD10 33 E50.7 H04.12
ICD9CM 35 375.15
MeSH 44 D014985
NCIt 50 C34503
SNOMED-CT 68 46152009 69316005

Summaries for Xerophthalmia

MalaCards based summary : Xerophthalmia, also known as conjunctival xerosis, is related to keratomalacia and sjogren syndrome, and has symptoms including dryness of eye and dacryops. An important gene associated with Xerophthalmia is RHO (Rhodopsin). The drugs Dipivefrin and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and liver.

Wikipedia : 76 Xerophthalmia (from Ancient Greek x�?rós (ξηρ�?�?) meaning dry and ophthalmos (ο�?θαλμ�?�?) meaning eye)... more...

Related Diseases for Xerophthalmia

Graphical network of the top 20 diseases related to Xerophthalmia:



Diseases related to Xerophthalmia

Symptoms & Phenotypes for Xerophthalmia

UMLS symptoms related to Xerophthalmia:


dryness of eye, dacryops

Drugs & Therapeutics for Xerophthalmia

Drugs for Xerophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 3 52365-63-6 3105
2
Oxybutynin Approved, Investigational Phase 3 5633-20-5 4634
3 Pharmaceutical Solutions Phase 3,Phase 1,Not Applicable
4 Ophthalmic Solutions Phase 3,Phase 1,Not Applicable
5 Cathartics Phase 3
6 Carboxymethylcellulose Sodium Phase 3
7 Gastrointestinal Agents Phase 3
8 Laxatives Phase 3
9 Vasopressins Phase 3
10 Neurotransmitter Agents Phase 3
11 Cholinergic Antagonists Phase 3
12 arginine Phase 3
13 Anti-Infective Agents, Urinary Phase 3
14 Parasympatholytics Phase 3
15 Coagulants Phase 3
16 Arginine Vasopressin Phase 3
17 Deamino Arginine Vasopressin Phase 3
18 Renal Agents Phase 3
19 Mandelic Acids Phase 3
20 Natriuretic Agents Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Cholinergic Agents Phase 3
23 Hemostatics Phase 3
24 Autonomic Agents Phase 3
25 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
26 Muscarinic Antagonists Phase 3
27
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
28
Iodine Approved, Investigational Phase 2 7553-56-2 807
29
Metformin Approved Phase 2 657-24-9 14219 4091
30
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
31 Keratolytic Agents Phase 2
32 Sunscreening Agents Phase 2
33 Radiation-Protective Agents Phase 2
34 Protective Agents Phase 2,Not Applicable
35 Dermatologic Agents Phase 2,Not Applicable
36 Trace Elements Phase 2,Not Applicable
37 Micronutrients Phase 2,Not Applicable
38 Antirheumatic Agents Phase 2,Not Applicable
39 Immunologic Factors Phase 2,Not Applicable
40 Hypoglycemic Agents Phase 2
41 cadexomer iodine Phase 2
42 Anti-Infective Agents, Local Phase 2
43 Immunosuppressive Agents Phase 2,Not Applicable
44
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
45
Hydroxychloroquine Approved 118-42-3 3652
46
Iron Approved Not Applicable 7439-89-6 23925
47
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
48
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
49
Ethyl cellulose Not Applicable 9004-57-3 24832091
50 Viscosupplements Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome Not yet recruiting NCT03711214 Phase 4
2 Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes Completed NCT00796926 Phase 3 Systane Ultra eyedrops;Refresh eye drops
3 Minirin Versus Oxybutynin for Nocturnal Enuresis in Children Completed NCT02538302 Phase 3 Minirin;Oxybutynin
4 Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis Completed NCT02278861 Phase 2 Oral isotretinoin;Tretinoin 0,05% cream;Sunscreen FPS 60
5 Metformin Hydrochloride in Mitigating Side Effects of Radioactive Iodine Treatment in Patients With Differentiated Thyroid Cancer Recruiting NCT03109847 Phase 2 Metformin Hydrochloride
6 Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study Withdrawn NCT02027298 Phase 2 Abatacept
7 Use of Autologous Serum Eye-drops as Tears in Patients With Recalcitrant Dry Eye Completed NCT01089985 Phase 1 Autologous serum eyedrops
8 Corneal Protect Used During Cataract Surgery Unknown status NCT02363530 Not Applicable
9 Tolerability, Safety and Efficacy of Lubricin Eye Drops Versus Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye Completed NCT02510235 Not Applicable
10 Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients Completed NCT00873496 Hydroxychloroquine
11 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089 Not Applicable
12 A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal Completed NCT01882413
13 Correlation of Noninvasive Tear Film Function and the Optical Quality in Mild and Moderate Dry Eye Recruiting NCT03815539 Not Applicable
14 Echo Systemic Sclerosis Recruiting NCT03143413
15 DRy Eye Outcome and Prescription Study Recruiting NCT03652415
16 The Effects of Biscuits Containing Red Palm Oil on School Children With Vitamin A Deficiency in West and East Malaysia Recruiting NCT03256123 Not Applicable
17 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
18 Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Not yet recruiting NCT03403023 Not Applicable Restasis
19 Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population Withdrawn NCT02655432

Search NIH Clinical Center for Xerophthalmia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: xerophthalmia

Genetic Tests for Xerophthalmia

Anatomical Context for Xerophthalmia

MalaCards organs/tissues related to Xerophthalmia:

41
Eye, Salivary Gland, Liver, Thyroid, Retina

Publications for Xerophthalmia

Articles related to Xerophthalmia:

(show top 50) (show all 263)
# Title Authors Year
1
Pilocarpine and Artificial Saliva for the Treatment of Xerostomia and Xerophthalmia of SjAPgren's Syndrome: A double blind control trial. ( 29432648 )
2018
2
Conjunctival xerosis caused by vitamin A deficiency. ( 28939634 )
2018
3
Xerophthalmia ( 28613746 )
2017
4
Sodium hyaluronate's effect on xerophthalmia: a meta-analysis of randomized controlled trials. ( 26613131 )
2016
5
Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia. ( 27820648 )
2016
6
Vitamin A deficiency and xerophthalmia in children of a developed country. ( 27439630 )
2016
7
Xerophthalmia and vitamin A deficiency in an autistic child with a restricted diet. ( 26438671 )
2015
8
Xerophthalmia of Sjogren's Syndrome Diagnosed with Anti-Salivary Gland Protein 1 Antibodies. ( 25076899 )
2014
9
Severe vitamin A deficiency in a child presenting as xerophthalmia. ( 25074858 )
2014
10
Xerophthalmia and keratomalacia secondary to diet-induced vitamin A deficiency in Scottish adults. ( 24513368 )
2014
11
Xerophthalmia--a potential epidemic on our doorstep? ( 24525868 )
2014
12
Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. ( 23334438 )
2013
13
Prevalence and determinants of xerophthalmia in rural children of Uttarpradesh, India. ( 24172559 )
2013
14
Prevalence of xerophthalmia among malnourished children in rural Ethiopia. ( 23354453 )
2013
15
Alagille syndrome associated with xerophthalmia. ( 24474934 )
2013
16
Epidemiology of vitamin A deficiency and xerophthalmia in at-risk populations. ( 22326691 )
2012
17
Xerophthalmia in a traditional Quran boarding school in Sudan. ( 22623857 )
2012
18
Xerophthalmia. ( 23008038 )
2012
19
Xerophthalmia: are we turning a blind eye to it..? ( 22796705 )
2012
20
Bilateral microbial keratitis in a case of severe xerophthalmia following small bowel resection. ( 21357982 )
2011
21
Serum retinol and xerophthalmia among a prison population in Papua New Guinea. ( 22053839 )
2011
22
Clinical curative effect of acupuncture therapy on xerophthalmia. ( 20626051 )
2010
23
Xerophthalmia and Intracranial Hypertension in an Autistic Child with Vitamin A Deficiency. ( 20411868 )
2010
24
Xerophthalmia because of dietary-induced vitamin a deficiency in a young Scottish man. ( 20489600 )
2010
25
Prevalence and determinants of xerophthalmia in preschool children in urban slums, Pune, India--a preliminary assessment. ( 19191176 )
2009
26
Antecedent risk factors of xerophthalmia among Indian rural preschool children. ( 18327046 )
2008
27
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. ( 18981849 )
2008
28
Effects of acupuncture and moxibustion on tear-film of the patients with xerophthalmia. ( 18246680 )
2007
29
Submandibular gland transfer for severe xerophthalmia. ( 17202928 )
2007
30
Mapping xerophthalmia in Mali: results of a national survey on regional distribution and related risk factors. ( 18187426 )
2007
31
Effects of coal dust contiguity on xerophthalmia development. ( 17687690 )
2007
32
Xerophthalmia secondary to alcohol-induced malnutrition. ( 16513513 )
2006
33
Xerophthalmia: a study among malnourished children of West Mednipur District. ( 16173295 )
2005
34
Vitamin A deficiency and xerophthalmia among school-aged children in Southeastern Asia. ( 15054414 )
2004
35
Risk factors for xerophthalmia among mothers and their children and for mother-child pairs with xerophthalmia in Cambodia. ( 15078669 )
2004
36
Xerophthalmia occurring after strabismus surgery. ( 15088058 )
2004
37
Nightblindness, xerophthalmia, and severe loss of visual acuity due to unnecessary dietary restriction. ( 15105037 )
2004
38
Cheek mucocele occurring long after parotid duct transplantation for xerophthalmia. ( 14587985 )
2003
39
Xerophthalmia and undiagnosed eating disorder. ( 12444238 )
2002
40
Xerophthalmia secondary to short bowel syndrome. ( 11911545 )
2002
41
Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. ( 11980857 )
2002
42
Xerophthalmia among hospitalized Iraqi children. ( 15603030 )
2002
43
Gastroesophageal reflux disease presenting as xerophthalmia. ( 11587183 )
2001
44
Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (SjAPgren's-like syndrome) in a cat. ( 11149716 )
2001
45
Transient hemifacial sensory loss with xerophthalmia following temporal lobectomy. ( 10975540 )
2000
46
Dietary practices and xerophthalmia in under-fives in Jimma town, southwest Ethiopia. ( 12858930 )
2000
47
Acute sixth nerve palsy in vitamin A treatment of xerophthalmia. ( 10979654 )
2000
48
Hyporetinolemia and acute phase proteins in children with and without xerophthalmia. ( 10871573 )
2000
49
Xerophthalmia and vitamin A deficiency in Nigeria. ( 10945070 )
2000
50
Prevalence of xerophthalmia among children in Beheira governorate, Egypt. ( 10983539 )
1999

Variations for Xerophthalmia

Expression for Xerophthalmia

Search GEO for disease gene expression data for Xerophthalmia.

Pathways for Xerophthalmia

GO Terms for Xerophthalmia

Biological processes related to Xerophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 8.62 HSPG2 RHO

Sources for Xerophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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