Aliases & Classifications for Xerophthalmia

MalaCards integrated aliases for Xerophthalmia:

Name: Xerophthalmia 12 76 55 44 15 73
Conjunctival Xerosis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10138
ICD10 33 E50.7 H04.12
ICD9CM 35 375.15
MeSH 44 D014985
NCIt 50 C34503

Summaries for Xerophthalmia

MalaCards based summary : Xerophthalmia, also known as conjunctival xerosis, is related to keratomalacia and sjogren syndrome, and has symptoms including dacryops and dryness of eye. An important gene associated with Xerophthalmia is RHO (Rhodopsin). The drugs Dipivefrin and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and liver.

Wikipedia : 76 Xerophthalmia (from Ancient Greek xērós (ξηρός) meaning dry and ophthalmos (οφθαλμός) meaning eye) is a... more...

Related Diseases for Xerophthalmia

Diseases related to Xerophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 keratomalacia 31.1 DNASE1L1 RHO
2 sjogren syndrome 29.0 HSPG2 TRIM21
3 keratoconjunctivitis sicca 11.1
4 dry eye syndrome 10.9
5 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.4
6 aging 10.1
7 heart block, congenital 10.1 CDSN TRIM21
8 night blindness 10.1
9 diffuse infiltrative lymphocytosis syndrome 10.0 CDSN TRIM21
10 cystic fibrosis 10.0
11 measles 10.0
12 keratopathy 9.9
13 short bowel syndrome 9.9
14 diarrhea 9.9
15 kwashiorkor 9.9
16 exanthem 9.8 HSPG2 TRIM21
17 autoimmune disease 9.7
18 gastroesophageal reflux 9.7
19 alagille syndrome 1 9.7
20 strabismus 9.7
21 intracranial hypertension, idiopathic 9.7
22 autoimmune disease 1 9.7
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
24 petrositis 9.7
25 abducens nerve disease 9.7
26 trachoma 9.7
27 acquired night blindness 9.7
28 facial paralysis 9.7
29 cellular schwannoma 9.7
30 conjunctival disease 9.7
31 corneal ulcer 9.7
32 eating disorder 9.7
33 intracranial hypertension 9.7
34 primary sjögren syndrome 9.7 HSPG2 TRIM21
35 hypersensitivity reaction disease 9.6 CDSN TRIM21
36 salivary gland disease 9.4 CDSN HSPG2 TRIM21
37 sialadenitis 9.4 CDSN HSPG2 TRIM21
38 hyperglobulinemic purpura 9.4 ATP6V0A4 HSPG2 TRIM21
39 lacrimal apparatus disease 9.0 CDSN DNASE1L1 HSPG2 TRIM21

Comorbidity relations with Xerophthalmia via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Xerophthalmia:



Diseases related to Xerophthalmia

Symptoms & Phenotypes for Xerophthalmia

UMLS symptoms related to Xerophthalmia:


dacryops, dryness of eye

Drugs & Therapeutics for Xerophthalmia

Drugs for Xerophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 3 52365-63-6 3105
2
Oxybutynin Approved, Investigational Phase 3 5633-20-5 4634
3 Pharmaceutical Solutions Phase 3,Phase 1,Not Applicable
4 Carboxymethylcellulose Sodium Phase 3
5 Cathartics Phase 3
6 Gastrointestinal Agents Phase 3
7 Laxatives Phase 3
8 Ophthalmic Solutions Phase 3,Phase 1,Not Applicable
9 Tetrahydrozoline Phase 3,Phase 1,Not Applicable
10 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
11 Arginine Vasopressin Phase 3
12 Autonomic Agents Phase 3,Phase 1,Not Applicable
13 Cholinergic Agents Phase 3
14 Cholinergic Antagonists Phase 3
15 Coagulants Phase 3
16 Deamino Arginine Vasopressin Phase 3
17 Hemostatics Phase 3
18 Mandelic Acids Phase 3
19 Muscarinic Antagonists Phase 3
20 Natriuretic Agents Phase 3
21 Neurotransmitter Agents Phase 3
22 Parasympatholytics Phase 3
23 Peripheral Nervous System Agents Phase 3,Phase 1,Not Applicable
24 Renal Agents Phase 3
25 Vasopressins Phase 3
26 arginine Nutraceutical Phase 3
27
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
28
Iodine Approved, Investigational Phase 2 7553-56-2 807
29
Metformin Approved Phase 2 657-24-9 14219 4091
30
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
31 Dermatologic Agents Phase 2,Not Applicable
32 Keratolytic Agents Phase 2
33 Protective Agents Phase 2,Not Applicable
34 Radiation-Protective Agents Phase 2
35 Sunscreening Agents Phase 2
36 Micronutrients Phase 2,Not Applicable
37 Trace Elements Phase 2,Not Applicable
38 Antirheumatic Agents Phase 2,Not Applicable
39 Anti-Infective Agents, Local Phase 2
40 cadexomer iodine Phase 2
41 Hypoglycemic Agents Phase 2
42 Immunosuppressive Agents Phase 2,Not Applicable
43
Ephedrine Approved Phase 1,Not Applicable 299-42-3 9294
44
Pseudoephedrine Approved Phase 1,Not Applicable 90-82-4 7028
45 Nasal Decongestants Phase 1,Not Applicable
46 Respiratory System Agents Phase 1,Not Applicable
47 Vasoconstrictor Agents Phase 1,Not Applicable
48
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
49
Hydroxychloroquine Approved 118-42-3 3652
50
Iron Approved Not Applicable 7439-89-6 23925

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes Completed NCT00796926 Phase 3 Systane Ultra eyedrops;Refresh eye drops
2 Minirin Versus Oxybutynin for Nocturnal Enuresis in Children Completed NCT02538302 Phase 3 Minirin;Oxybutynin
3 Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis Completed NCT02278861 Phase 2 Oral isotretinoin;Tretinoin 0,05% cream;Sunscreen FPS 60
4 Metformin Hydrochloride in Mitigating Side Effects of Radioactive Iodine Treatment in Patients With Differentiated Thyroid Cancer Recruiting NCT03109847 Phase 2 Metformin Hydrochloride
5 Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study Withdrawn NCT02027298 Phase 2 Abatacept
6 Use of Autologous Serum Eye-drops as Tears in Patients With Recalcitrant Dry Eye Completed NCT01089985 Phase 1 Autologous serum eyedrops
7 Corneal Protect Used During Cataract Surgery Unknown status NCT02363530 Not Applicable
8 Tolerability, Safety and Efficacy of Lubricin Eye Drops Versus Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye Completed NCT02510235 Not Applicable
9 Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients Completed NCT00873496 Hydroxychloroquine
10 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089 Not Applicable
11 A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal Completed NCT01882413
12 Echo Systemic Sclerosis Recruiting NCT03143413
13 The Effects of Biscuits Containing Red Palm Oil on School Children With Vitamin A Deficiency in West and East Malaysia Recruiting NCT03256123 Not Applicable
14 Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Not yet recruiting NCT03403023 Not Applicable Restasis
15 Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population Withdrawn NCT02655432

Search NIH Clinical Center for Xerophthalmia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: xerophthalmia

Genetic Tests for Xerophthalmia

Anatomical Context for Xerophthalmia

MalaCards organs/tissues related to Xerophthalmia:

41
Eye, Thyroid, Liver, Salivary Gland, Retina

Publications for Xerophthalmia

Articles related to Xerophthalmia:

(show top 50) (show all 249)
# Title Authors Year
1
Pilocarpine and Artificial Saliva for the Treatment of Xerostomia and Xerophthalmia of SjAPgren's Syndrome: A double blind control trial. ( 29432648 )
2018
2
Xerophthalmia ( 28613746 )
2017
3
Sodium hyaluronate's effect on xerophthalmia: a meta-analysis of randomized controlled trials. ( 26613131 )
2016
4
Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia. ( 27820648 )
2016
5
Vitamin A deficiency and xerophthalmia in children of a developed country. ( 27439630 )
2016
6
Xerophthalmia and vitamin A deficiency in an autistic child with a restricted diet. ( 26438671 )
2015
7
Xerophthalmia of Sjogren's Syndrome Diagnosed with Anti-Salivary Gland Protein 1 Antibodies. ( 25076899 )
2014
8
Severe vitamin A deficiency in a child presenting as xerophthalmia. ( 25074858 )
2014
9
Xerophthalmia and keratomalacia secondary to diet-induced vitamin A deficiency in Scottish adults. ( 24513368 )
2014
10
Xerophthalmia--a potential epidemic on our doorstep? ( 24525868 )
2014
11
Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. ( 23334438 )
2013
12
Prevalence and determinants of xerophthalmia in rural children of Uttarpradesh, India. ( 24172559 )
2013
13
Prevalence of xerophthalmia among malnourished children in rural Ethiopia. ( 23354453 )
2013
14
Alagille syndrome associated with xerophthalmia. ( 24474934 )
2013
15
Epidemiology of vitamin A deficiency and xerophthalmia in at-risk populations. ( 22326691 )
2012
16
Xerophthalmia in a traditional Quran boarding school in Sudan. ( 22623857 )
2012
17
Xerophthalmia. ( 23008038 )
2012
18
Xerophthalmia: are we turning a blind eye to it..? ( 22796705 )
2012
19
Bilateral microbial keratitis in a case of severe xerophthalmia following small bowel resection. ( 21357982 )
2011
20
Serum retinol and xerophthalmia among a prison population in Papua New Guinea. ( 22053839 )
2011
21
Clinical curative effect of acupuncture therapy on xerophthalmia. ( 20626051 )
2010
22
Xerophthalmia and Intracranial Hypertension in an Autistic Child with Vitamin A Deficiency. ( 20411868 )
2010
23
Xerophthalmia because of dietary-induced vitamin a deficiency in a young Scottish man. ( 20489600 )
2010
24
Prevalence and determinants of xerophthalmia in preschool children in urban slums, Pune, India--a preliminary assessment. ( 19191176 )
2009
25
Antecedent risk factors of xerophthalmia among Indian rural preschool children. ( 18327046 )
2008
26
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. ( 18981849 )
2008
27
Effects of acupuncture and moxibustion on tear-film of the patients with xerophthalmia. ( 18246680 )
2007
28
Submandibular gland transfer for severe xerophthalmia. ( 17202928 )
2007
29
Mapping xerophthalmia in Mali: results of a national survey on regional distribution and related risk factors. ( 18187426 )
2007
30
Effects of coal dust contiguity on xerophthalmia development. ( 17687690 )
2007
31
Xerophthalmia secondary to alcohol-induced malnutrition. ( 16513513 )
2006
32
Xerophthalmia: a study among malnourished children of West Mednipur District. ( 16173295 )
2005
33
Vitamin A deficiency and xerophthalmia among school-aged children in Southeastern Asia. ( 15054414 )
2004
34
Risk factors for xerophthalmia among mothers and their children and for mother-child pairs with xerophthalmia in Cambodia. ( 15078669 )
2004
35
Xerophthalmia occurring after strabismus surgery. ( 15088058 )
2004
36
Nightblindness, xerophthalmia, and severe loss of visual acuity due to unnecessary dietary restriction. ( 15105037 )
2004
37
Cheek mucocele occurring long after parotid duct transplantation for xerophthalmia. ( 14587985 )
2003
38
Xerophthalmia and undiagnosed eating disorder. ( 12444238 )
2002
39
Xerophthalmia secondary to short bowel syndrome. ( 11911545 )
2002
40
Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. ( 11980857 )
2002
41
Xerophthalmia among hospitalized Iraqi children. ( 15603030 )
2002
42
Gastroesophageal reflux disease presenting as xerophthalmia. ( 11587183 )
2001
43
Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (SjAPgren's-like syndrome) in a cat. ( 11149716 )
2001
44
Transient hemifacial sensory loss with xerophthalmia following temporal lobectomy. ( 10975540 )
2000
45
Dietary practices and xerophthalmia in under-fives in Jimma town, southwest Ethiopia. ( 12858930 )
2000
46
Acute sixth nerve palsy in vitamin A treatment of xerophthalmia. ( 10979654 )
2000
47
Hyporetinolemia and acute phase proteins in children with and without xerophthalmia. ( 10871573 )
2000
48
Xerophthalmia and vitamin A deficiency in Nigeria. ( 10945070 )
2000
49
Prevalence of xerophthalmia among children in Beheira governorate, Egypt. ( 10983539 )
1999
50
Malnutrition and xerophthalmia in rural communities of Ethiopia. ( 10734513 )
1999

Variations for Xerophthalmia

Expression for Xerophthalmia

Search GEO for disease gene expression data for Xerophthalmia.

Pathways for Xerophthalmia

GO Terms for Xerophthalmia

Cellular components related to Xerophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ARSI CDSN DNASE1L1 GABBR1 HSPG2

Biological processes related to Xerophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 8.62 HSPG2 RHO

Sources for Xerophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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