MCID: YWS001
MIFTS: 38

Yaws

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Yaws

MalaCards integrated aliases for Yaws:

Name: Yaws 12 76 53 44 15 73
Frambesia Tropica 12 53
Frambesia 12 53
Treponema Pertenue Infection 53
Polypapilloma Tropicum 12
Endemic Treponematoses 53
Frambosie 12
Thymosis 12
Bouba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10371
ICD10 33 A66 A66.9
ICD9CM 35 102 102.9
MeSH 44 D015001
NCIt 50 C41353
UMLS 73 C0043388

Summaries for Yaws

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has material basis in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions.

MalaCards based summary : Yaws, also known as frambesia tropica, is related to bejel and syphilis. An important gene associated with Yaws is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Menthol and Nimodipine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes.

Wikipedia : 76 Yaws is a tropical infection of the skin, bones and joints caused by the spirochete bacterium Treponema... more...

Related Diseases for Yaws

Diseases related to Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 bejel 30.3 CAVIN4 EPB41L3 TPR
2 syphilis 30.1 EXTL3 TPR
3 secondary syphilis 29.1 EXTL3 TPR
4 late yaws 12.5
5 early yaws 12.5
6 trachoma 10.2
7 skin disease 10.0
8 motion sickness 10.0
9 leishmaniasis 10.0
10 treponema infection 10.0
11 pneumonia 9.9
12 latent syphilis 9.8 EXTL3 TPR
13 hemifacial hyperplasia 9.7
14 3-methylglutaconic aciduria, type iii 9.7
15 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
16 cutaneous leishmaniasis 9.7
17 trypanosomiasis 9.7
18 pertussis 9.7
19 tetanus 9.7
20 urethritis 9.7
21 lymphogranuloma venereum 9.7
22 papilloma 9.7
23 chickenpox 9.7
24 smallpox 9.7
25 amebiasis 9.7
26 yellow fever 9.7

Comorbidity relations with Yaws via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Yaws:



Diseases related to Yaws

Symptoms & Phenotypes for Yaws

Drugs & Therapeutics for Yaws

Drugs for Yaws (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 120)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
3
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
4
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
5
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
6
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
7
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
8
Promethazine Approved, Investigational Phase 4 60-87-7 4927
9
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
10
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
11
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
12 Antihypertensive Agents Phase 4,Not Applicable
13 calcium channel blockers Phase 4
14 Calcium, Dietary Phase 4
15 Vasodilator Agents Phase 4
16 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
17 Antiparasitic Agents Phase 4,Not Applicable
18 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
19 Anesthetics, Local Phase 4,Not Applicable
20 Anti-Allergic Agents Phase 4
21 Antiemetics Phase 4,Phase 3,Not Applicable
22 Antipruritics Phase 4
23 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
25 Dermatologic Agents Phase 4,Phase 3
26 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
27 Histamine Antagonists Phase 4
28 Histamine H1 Antagonists Phase 4
29
Histamine Phosphate Phase 4 51-74-1 65513
30 Hypnotics and Sedatives Phase 4
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Central Nervous System Stimulants Phase 4
34 Dopamine Agents Phase 4,Phase 3
35 Dopamine Uptake Inhibitors Phase 4
36 Lisdexamfetamine Dimesylate Phase 4
37 Neurotransmitter Uptake Inhibitors Phase 4
38 Anticoagulants Phase 4
39 Chelating Agents Phase 4
40 diuretics Phase 4
41 Expectorants Phase 4
42 Natriuretic Agents Phase 4
43 Respiratory System Agents Phase 4
44 Citrate Nutraceutical Phase 4
45
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
46
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
47
Glyburide Approved Phase 3 10238-21-8 3488
48
Metformin Approved Phase 3 657-24-9 14219 4091
49
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
50
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
2 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Completed NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
3 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo
4 Does Pharmacological Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adults Enhance Parenting Performance? Completed NCT01127607 Phase 4 lisdexamfetamine
5 A Study on the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence Recruiting NCT03007160 Phase 4 Potassium Citrate Extended-release Tablets
6 Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication Not yet recruiting NCT03490123 Phase 4 R1-Total community treatment with azithromycin;R2-Total community treatment with azithromycin;R3-Total community treatment with azithromycin;R2-Total targeted treatment with azithromycin;R3-Total targeted treatment with azithromycin
7 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
8 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Completed NCT02344628 Phase 3 Azithromycin
9 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
10 Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide Completed NCT00279045 Phase 3 Rosiglitazone;glyburide;metformin
11 Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241540 Phase 3 Esomeprazole
12 Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241514 Phase 3 Esomeprazole
13 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3 trofosfamide, idarubicin, etoposide
14 Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT Active, not recruiting NCT02779959 Phase 3 Prochlorperazine
15 The Phase III Study of Icaritin Versus HUACHANSU PIAN in Hepatocellular Carcinoma Subjects Not yet recruiting NCT03236636 Phase 3 Icaritin;HUACHANSU PIAN
16 The Role of Traditional Chinese Medicine in the Treatment of Chronic Childhood Immune Thrombocytopenia (ITP) Terminated NCT01226524 Phase 2, Phase 3 Bu Zhong Yi Qi Tang, Zhi Xue Tang, Chuan xin lian kang yan pian mod, Tian Wang Bu xin Dan
17 Pharmacokinetic and Efficacy Profile Intranasal Scopolamine Spray Terminated NCT02155309 Phase 2, Phase 3 Scopolamine;Placebo
18 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
19 Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine Not yet recruiting NCT02937207 Phase 2 Ke Chuan Liu Wei Mixture;Chuan Xiong Ping Chuan Mixture;Xie Wu Capsule;Dan Ma Jia Tablet;Zhi Chuan Capsule;Bu Shen Na Qi Granule;Ke Chuan Liu Wei Mixture placebo;Chuan Xiong Ping Chuan Mixture placebo;Xie Wu Capsule placebo;Dan Ma Jia Tablet placebo;Zhi Chuan Capsule placebo;Bu Shen Na Qi Granule placebo
20 Study Exploring Safety, Pharmacokinetic and Pharmacodynamic of BN82451 in Male Huntington's Disease Patients Terminated NCT02231580 Phase 2 BN82451B;Placebo
21 Transcutaneous Electrical Acupoint Stimulation for Non-small Cell Lung Cancer Patients Unknown status NCT02663492 Not Applicable Sanguisorba officinalis L.
22 Functioning Disturbance in Chronic Back Pain: Altered Muscle Metabolism Unknown status NCT01593839
23 RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis Unknown status NCT02648698 Not Applicable antibiotics;placebo
24 Simulation-based Arthroscopic Surgery Study Unknown status NCT02777333 Not Applicable
25 Dual Point-of-care Test for the Diagnosis of Yaws Completed NCT01841203
26 Postural Effects of Being Rotated in a Whole Body Gyroscope Completed NCT01188161
27 Resistive/Cardiovascular Training Study Completed NCT00835601
28 The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation Completed NCT02768168 Not Applicable dezocine
29 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
30 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
31 Three-dimensional Virtual Reality Procedures in Vestibular Rehabilitation Recruiting NCT03553264 Not Applicable
32 The Smart Hypertension Control Study Recruiting NCT03288142 Not Applicable
33 Clinical Accuracy of Patient-specific Implants in Genioplasty Recruiting NCT03456869 Not Applicable
34 Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering Recruiting NCT03375216 Not Applicable
35 Plasma Concentrations of Prophylactic Cefazolin in Pediatric Patients Undergoing Cardiac Surgery With CPB Recruiting NCT03141450
36 GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs Recruiting NCT03522025 Not Applicable
37 Percutaneous Transluminal Angioplasty Registry Recruiting NCT02728479
38 Study on Nation-wide Health Care Quality Information Openness and Transparency Mechanism Establishment No longer available NCT01194011
39 The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients Terminated NCT00164814
40 Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone Terminated NCT00519584 Not Applicable Ropivacaine;dex;Bupivacaine;Saline

Search NIH Clinical Center for Yaws

Cochrane evidence based reviews: yaws

Genetic Tests for Yaws

Anatomical Context for Yaws

MalaCards organs/tissues related to Yaws:

41
Skin, Bone, Testes, Lung, Eye, Appendix

Publications for Yaws

Articles related to Yaws:

(show top 50) (show all 459)
# Title Authors Year
1
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea. ( 29456191 )
2018
2
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. ( 29566044 )
2018
3
Correction: Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 29513663 )
2018
4
Macrolide resistance in yaws. ( 29428184 )
2018
5
Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. ( 29428183 )
2018
6
Low-dose versus standard-dose azithromycin for treatment of yaws. ( 29456192 )
2018
7
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences. ( 29672524 )
2018
8
Yaws Eradication Requires Improved Approach. ( 29677311 )
2018
9
Targeted presurgical decompensation in patients with yaw-dependent facial asymmetry. ( 28523246 )
2017
10
The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance. ( 29073145 )
2017
11
New Diagnostics for Yaws. ( 28077737 )
2017
12
Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study. ( 29107621 )
2017
13
Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana. ( 28759580 )
2017
14
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. ( 28072863 )
2017
15
Mathematical Modeling of Programmatic Requirements for Yaws Eradication. ( 27983500 )
2017
16
Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities. ( 28481900 )
2017
17
Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea. ( 29281641 )
2017
18
Targeted Treatment of Yaws With Household Contact Tracing: How Much do we Miss? ( 29140407 )
2017
19
Diagnostics for yaws eradication: insights from direct next generation sequencing of cutaneous strains of Treponema pallidum. ( 29045605 )
2017
20
Single-dose azithromycin to treat latent yaws. ( 29107622 )
2017
21
Vection is the main contributor to motion sickness induced by visual yaw rotation: Implications for conflict and eye movement theories. ( 28380077 )
2017
22
Bone lesions in yaws - another potential marker of indigenous Australian remains. ( 28695420 )
2017
23
Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. ( 28193743 )
2017
24
Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu. ( 28118354 )
2017
25
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
26
Meta-analysis of the performance of a combined treponemal and non-treponemal rapid diagnostic test for syphilis and yaws. ( 27217216 )
2016
27
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 27551787 )
2016
28
Yaws: towards the WHO eradication target. ( 27268712 )
2016
29
WHO Declares India Free of Yaws and Maternal and Neonatal Tetanus. ( 27654592 )
2016
30
Evaluation of Multiplex-Based Antibody Testing for Use in Large-Scale Surveillance for Yaws: a Comparative Study. ( 26962086 )
2016
31
Flies and Yaws: Molecular Studies Provide New Insight. ( 27568221 )
2016
32
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626526 )
2016
33
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626525 )
2016
34
Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana. ( 27531187 )
2016
35
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626527 )
2016
36
Yaws: 110 Years After Castellani's Discovery of Treponema pallidum Subspecies pertenue. ( 25870417 )
2015
37
Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. ( 25422395 )
2015
38
Global epidemiology of yaws: a systematic review. ( 26001576 )
2015
39
Yaws. ( 25525120 )
2015
40
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. ( 26241484 )
2015
41
Eradication of yaws in India. ( 25902561 )
2015
42
Mass treatment with single-dose azithromycin for yaws. ( 25693010 )
2015
43
Trachoma and Yaws: Common Ground? ( 26633176 )
2015
44
Tropical leg ulcers in children: more than yaws. ( 26289420 )
2015
45
A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control. ( 25632942 )
2015
46
Eradicating successfully yaws from India: The strategy & global lessons. ( 26139778 )
2015
47
Challenges and key research questions for yaws eradication. ( 26362174 )
2015
48
Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains? ( 26217043 )
2015
49
Yaws eradication--a goal finally within reach. ( 25693007 )
2015
50
Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws. ( 26125585 )
2015

Variations for Yaws

Expression for Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for Yaws

GO Terms for Yaws

Sources for Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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