YAWS
MCID: YWS001
MIFTS: 42

Yaws (YAWS)

Categories: Bone diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Yaws

MalaCards integrated aliases for Yaws:

Name: Yaws 12 77 54 45 15 17 74
Frambesia Tropica 12 54
Frambesia 12 54
Treponema Pertenue Infection 54
Polypapilloma Tropicum 12
Endemic Treponematoses 54
Frambosie 12
Thymosis 12
Bouba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10371
ICD9CM 36 102 102.9
MeSH 45 D015001
NCIt 51 C41353
SNOMED-CT 69 70647001
ICD10 34 A66 A66.9
UMLS 74 C0043388

Summaries for Yaws

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has material basis in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions.

MalaCards based summary : Yaws, also known as frambesia tropica, is related to bejel and syphilis. An important gene associated with Yaws is EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3). The drugs Nimodipine and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotype is Negative genetic interaction between PTEN-/- and PTEN+/+.

Wikipedia : 77 Yaws is a tropical infection of the skin, bones and joints caused by the spirochete bacterium Treponema... more...

Related Diseases for Yaws

Diseases in the Yaws family:

Late Yaws Early Yaws

Diseases related to Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 bejel 32.1 EPB41L3 TPR
2 syphilis 30.4 EXTL3 MYH9 TPR
3 secondary syphilis 29.4 EXTL3 TPR
4 late yaws 12.7
5 early yaws 12.7
6 trachoma 10.3
7 pathologic nystagmus 10.3
8 motion sickness 10.1
9 leishmaniasis 10.1
10 pinta disease 10.1
11 skin disease 10.1
12 primary syphilis 9.9 EXTL3 MYH9
13 hemifacial hyperplasia 9.9
14 meniere disease 9.9
15 hemifacial microsomia 9.9
16 3-methylglutaconic aciduria, type iii 9.9
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
18 cutaneous leishmaniasis 9.9
19 trypanosomiasis 9.9
20 pertussis 9.9
21 tetanus 9.9
22 dysentery 9.9
23 urethritis 9.9
24 lymphogranuloma venereum 9.9
25 papilloma 9.9
26 plague 9.9
27 herpes zoster 9.9
28 chickenpox 9.9
29 smallpox 9.9
30 amebiasis 9.9
31 yellow fever 9.9
32 degos 'en cocarde' erythrokeratoderma 9.9
33 tertiary syphilis 9.9 EXTL3 MYH9
34 congenital syphilis 9.9 EXTL3 MYH9
35 asymptomatic neurosyphilis 9.8 EXTL3 MYH9
36 tertiary neurosyphilis 9.7 EXTL3 MYH9
37 latent syphilis 9.5 EXTL3 MYH9 TPR

Comorbidity relations with Yaws via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Yaws:



Diseases related to Yaws

Symptoms & Phenotypes for Yaws

GenomeRNAi Phenotypes related to Yaws according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 8.8 CPZ MYH9 TPR

Drugs & Therapeutics for Yaws

Drugs for Yaws (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
2
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 70288-86-7 6474909
3
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
4
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
5
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
6
Promethazine Approved, Investigational Phase 4 60-87-7 4927
7
Histamine Approved, Investigational Phase 4 51-45-6 774
8
Dopamine Approved Phase 4,Phase 3,Early Phase 1 62-31-7, 51-61-6 681
9
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
10
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
11
Sodium Citrate Approved, Investigational Phase 4 68-04-2
12
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
13
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
14
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
15 Vasodilator Agents Phase 4
16 Hormones Phase 4,Not Applicable
17 calcium channel blockers Phase 4
18 Calcium, Dietary Phase 4
19 Antihypertensive Agents Phase 4
20 Antiparasitic Agents Phase 4,Phase 3,Phase 2
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2
22 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
24 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
25 Anesthetics, Local Phase 4,Not Applicable
26 Histamine H1 Antagonists Phase 4
27
Histamine Phosphate Phase 4 51-74-1 65513
28 Anti-Allergic Agents Phase 4
29 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
32 Antipruritics Phase 4
33 Dermatologic Agents Phase 4,Phase 3
34 Histamine Antagonists Phase 4
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Hypnotics and Sedatives Phase 4
37 Central Nervous System Stimulants Phase 4
38 Dopamine Uptake Inhibitors Phase 4
39 Neurotransmitter Uptake Inhibitors Phase 4
40 Dopamine Agents Phase 4,Phase 3,Early Phase 1
41 Lisdexamfetamine Dimesylate Phase 4
42 Penicillin G Procaine Phase 4,Phase 3
43 penicillins Phase 4,Phase 3
44 Anti-Bacterial Agents Phase 4,Phase 3
45 Penicillin G Benzathine Phase 4,Phase 3
46 Natriuretic Agents Phase 4
47 Chelating Agents Phase 4
48 Expectorants Phase 4
49 Respiratory System Agents Phase 4
50 Anticoagulants Phase 4

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
2 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Completed NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
3 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo
4 Does Pharmacological Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adults Enhance Parenting Performance? Completed NCT01127607 Phase 4 lisdexamfetamine
5 A Study on the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence Recruiting NCT03007160 Phase 4 Potassium Citrate Extended-release Tablets
6 Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication Active, not recruiting NCT03490123 Phase 4 R1-Total community treatment with azithromycin;R2-Total community treatment with azithromycin;R3-Total community treatment with azithromycin;R2-Total targeted treatment with azithromycin;R3-Total targeted treatment with azithromycin
7 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
8 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Completed NCT02344628 Phase 3 Azithromycin
9 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
10 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
11 Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide Completed NCT00279045 Phase 3 Rosiglitazone;glyburide;metformin
12 Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241540 Phase 3 Esomeprazole
13 Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241514 Phase 3 Esomeprazole
14 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3 trofosfamide, idarubicin, etoposide
15 A Study Comparing LY900014 to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes Using Insulin Pump Therapy Recruiting NCT03830281 Phase 3 LY900014;Insulin Lispro
16 Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT Active, not recruiting NCT02779959 Phase 3 Prochlorperazine
17 The Phase III Study of Icaritin Versus HUACHANSU PIAN in Hepatocellular Carcinoma Subjects Not yet recruiting NCT03236636 Phase 3 Icaritin;HUACHANSU PIAN
18 The Role of Traditional Chinese Medicine in the Treatment of Chronic Childhood Immune Thrombocytopenia (ITP) Terminated NCT01226524 Phase 2, Phase 3 Bu Zhong Yi Qi Tang, Zhi Xue Tang, Chuan xin lian kang yan pian mod, Tian Wang Bu xin Dan
19 Pharmacokinetic and Efficacy Profile Intranasal Scopolamine Spray Terminated NCT02155309 Phase 2, Phase 3 Scopolamine;Placebo
20 PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Completed NCT03664063 Phase 2 Azithromycin;Albendazole;Ivermectin;Diethylcarbamazine
21 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
22 Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine Not yet recruiting NCT02937207 Phase 2 Ke Chuan Liu Wei Mixture;Chuan Xiong Ping Chuan Mixture;Xie Wu Capsule;Dan Ma Jia Tablet;Zhi Chuan Capsule;Bu Shen Na Qi Granule;Ke Chuan Liu Wei Mixture placebo;Chuan Xiong Ping Chuan Mixture placebo;Xie Wu Capsule placebo;Dan Ma Jia Tablet placebo;Zhi Chuan Capsule placebo;Bu Shen Na Qi Granule placebo
23 Study Exploring Safety, Pharmacokinetic and Pharmacodynamic of BN82451 in Male Huntington's Disease Patients Terminated NCT02231580 Phase 2 BN82451B;Placebo
24 Transcutaneous Electrical Acupoint Stimulation for Non-small Cell Lung Cancer Patients Unknown status NCT02663492 Not Applicable Sanguisorba officinalis L.
25 Functioning Disturbance in Chronic Back Pain: Altered Muscle Metabolism Unknown status NCT01593839
26 Simulation-based Arthroscopic Surgery Study Unknown status NCT02777333 Not Applicable
27 Dual Point-of-care Test for the Diagnosis of Yaws Completed NCT01841203
28 Postural Effects of Being Rotated in a Whole Body Gyroscope Completed NCT01188161
29 Resistive/Cardiovascular Training Study Completed NCT00835601
30 The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation Completed NCT02768168 Not Applicable dezocine
31 Effect of Lumbar Stabilization Exercises and Circular Dances in Chronic Non Specific Low Back Pain Completed NCT02807090 Not Applicable
32 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
33 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
34 Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia Recruiting NCT03683745
35 Digital Behavioral Pain Medicine for Orthopedic Trauma Surgery Patients Recruiting NCT03764839 Not Applicable
36 Three-dimensional Virtual Reality Procedures in Vestibular Rehabilitation Recruiting NCT03553264 Not Applicable
37 Clinical Accuracy of Patient-specific Implants in Genioplasty Recruiting NCT03456869 Not Applicable
38 Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering Recruiting NCT03375216 Not Applicable
39 Improving Walking Automaticity in Parkinson's Disease: Levodopa or Donepezil Recruiting NCT03599726 Early Phase 1 Donepezil;Placebo
40 GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs Recruiting NCT03522025 Not Applicable
41 Percutaneous Transluminal Angioplasty Registry Recruiting NCT02728479
42 Study on Nation-wide Health Care Quality Information Openness and Transparency Mechanism Establishment No longer available NCT01194011
43 The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients Terminated NCT00164814
44 Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone Terminated NCT00519584 Not Applicable Ropivacaine;dex;Bupivacaine;Saline

Search NIH Clinical Center for Yaws

Cochrane evidence based reviews: yaws

Genetic Tests for Yaws

Anatomical Context for Yaws

MalaCards organs/tissues related to Yaws:

42
Skin, Bone, Testes, Appendix

Publications for Yaws

Articles related to Yaws:

(show top 50) (show all 516)
# Title Authors Year
1
Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws. ( 30601824 )
2019
2
Absence of Serological Evidence of Exposure to Treponema pallidum among Children Suggests Yaws Is No Longer Endemic in Kiribati. ( 30719964 )
2019
3
Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal. ( 30802249 )
2019
4
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea. ( 29456191 )
2018
5
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. ( 29566044 )
2018
6
Correction: Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 29513663 )
2018
7
Macrolide resistance in yaws. ( 29428184 )
2018
8
Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. ( 29428183 )
2018
9
Low-dose versus standard-dose azithromycin for treatment of yaws. ( 29456192 )
2018
10
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences. ( 29672524 )
2018
11
Yaws Eradication Requires Improved Approach. ( 29677311 )
2018
12
Molecular strain typing of the yaws pathogen, Treponema pallidum subspecies pertenue. ( 30208094 )
2018
13
Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue. ( 30228266 )
2018
14
Advances in the Treatment of Yaws. ( 30274488 )
2018
15
Spatial-temporal clustering analysis of yaws on Lihir Island, Papua New Guinea to enhance planning and implementation of eradication programs. ( 30372426 )
2018
16
Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting. ( 30513075 )
2018
17
The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance. ( 29073145 )
2017
18
New Diagnostics for Yaws. ( 28077737 )
2017
19
Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study. ( 29107621 )
2017
20
Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana. ( 28759580 )
2017
21
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. ( 28072863 )
2017
22
Mathematical Modeling of Programmatic Requirements for Yaws Eradication. ( 27983500 )
2017
23
Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities. ( 28481900 )
2017
24
Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea. ( 29281641 )
2017
25
Targeted Treatment of Yaws With Household Contact Tracing: How Much do we Miss? ( 29140407 )
2017
26
Diagnostics for yaws eradication: insights from direct next generation sequencing of cutaneous strains of Treponema pallidum. ( 29045605 )
2017
27
Single-dose azithromycin to treat latent yaws. ( 29107622 )
2017
28
Bone lesions in yaws - another potential marker of indigenous Australian remains. ( 28695420 )
2017
29
Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. ( 28193743 )
2017
30
Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu. ( 28118354 )
2017
31
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
32
Meta-analysis of the performance of a combined treponemal and non-treponemal rapid diagnostic test for syphilis and yaws. ( 27217216 )
2016
33
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 27551787 )
2016
34
Yaws: towards the WHO eradication target. ( 27268712 )
2016
35
WHO Declares India Free of Yaws and Maternal and Neonatal Tetanus. ( 27654592 )
2016
36
Evaluation of Multiplex-Based Antibody Testing for Use in Large-Scale Surveillance for Yaws: a Comparative Study. ( 26962086 )
2016
37
Flies and Yaws: Molecular Studies Provide New Insight. ( 27568221 )
2016
38
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626526 )
2016
39
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626525 )
2016
40
Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana. ( 27531187 )
2016
41
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626527 )
2016
42
Yaws: 110 Years After Castellani's Discovery of Treponema pallidum Subspecies pertenue. ( 25870417 )
2015
43
Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. ( 25422395 )
2015
44
Global epidemiology of yaws: a systematic review. ( 26001576 )
2015
45
Yaws. ( 25525120 )
2015
46
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. ( 26241484 )
2015
47
Eradication of yaws in India. ( 25902561 )
2015
48
Mass treatment with single-dose azithromycin for yaws. ( 25693010 )
2015
49
Trachoma and Yaws: Common Ground? ( 26633176 )
2015
50
Tropical leg ulcers in children: more than yaws. ( 26289420 )
2015

Variations for Yaws

Expression for Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for Yaws

GO Terms for Yaws

Cellular components related to Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 8.62 MYH9 TPR

Biological processes related to Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell shape GO:0008360 8.96 EPB41L3 MYH9
2 actomyosin structure organization GO:0031032 8.62 EPB41L3 MYH9

Molecular functions related to Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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