LYYN
MCID: YLL001
MIFTS: 41

Yellow Nail Syndrome (LYYN)

Categories: Cardiovascular diseases, Fetal diseases, Immune diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Yellow Nail Syndrome

MalaCards integrated aliases for Yellow Nail Syndrome:

Name: Yellow Nail Syndrome 57 12 73 20 58 72 44 15 17 32
Yns 57 20 58 72
Lymphedema with Yellow Nails 20 58
Lymphedema and Yellow Nails 57 72
Hereditary Lymphedema and Yellow Nails 70
Lymphedema-Yellow Nails 72
Lyyn 72

Characteristics:

Orphanet epidemiological data:

58
yellow nail syndrome
Age of onset: Adult; Age of death: elderly;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant

Miscellaneous:
yellow nails have been observed in some patients with a mutation in the forkhead box c2 gene (foxc2, )


HPO:

31
yellow nail syndrome:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare respiratory diseases
Rare skin diseases
Developmental anomalies during embryogenesis


Summaries for Yellow Nail Syndrome

GARD : 20 Yellow nail syndrome is a very rare disorder characterized by three features: yellow nail discoloration, respiratory problems, and lower limb swelling ( lymphedema ). It usually occurs in people over age 50, but can occur in younger people. In addition to being yellow, nails may lack a cuticle, grow very slowly, and become detached ( onycholysis ). Respiratory problems may include chronic cough, bronchiectasis, and pleural effusion. Chronic sinusitis may also occur. The cause of yellow nail syndrome remains unknown. It usually occurs on its own, but is sometimes associated with autoimmune disease, lymphatic diseases, or cancers. Some researchers have hypothesized that titanium may play a role in the development of yellow nail syndrome (for example, in dental or joint implants or other environmental exposures). Treatment addresses each symptom present. In some cases, yellow nail syndrome goes away on its own.

MalaCards based summary : Yellow Nail Syndrome, also known as yns, is related to hereditary lymphedema i and pericardial effusion, and has symptoms including yellow nails An important gene associated with Yellow Nail Syndrome is ALB (Albumin). Affiliated tissues include lung, skin and liver, and related phenotypes are lymphedema and fingernail dysplasia

Disease Ontology : 12 A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached.

OMIM® : 57 Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007). (153300) (Updated 05-Apr-2021)

UniProtKB/Swiss-Prot : 72 Lymphedema-yellow nails: A disorder characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.

Wikipedia : 73 Yellow nail syndrome, also known as "primary lymphedema associated with yellow nails and pleural... more...

Related Diseases for Yellow Nail Syndrome

Diseases related to Yellow Nail Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 hereditary lymphedema i 31.3 SOX18 FOXC2 CCR6
2 pericardial effusion 30.5 ALB ADA
3 pleural empyema 30.3 ALB ADA
4 pericarditis 30.1 ALB ADA
5 lymphedema-distichiasis syndrome 30.1 SOX18 FOXC2
6 acquired immunodeficiency syndrome 29.6 CCR6 ALB ADA
7 bronchiectasis 10.7
8 ascites, chylous 10.4
9 lymphangiectasis 10.4
10 hemopericardium 10.4
11 bronchitis 10.3
12 lung disease 10.3
13 primary lymphedema 10.3
14 lichen planus 10.2
15 anti-basement membrane glomerulonephritis 10.2 CCR6 ALB
16 toxic megacolon 10.2 CCR6 ALB
17 mucormycosis 10.2 CCR6 ALB
18 fungal meningitis 10.2 CCR6 ALB
19 acute proliferative glomerulonephritis 10.2 CCR6 ALB
20 clostridium difficile colitis 10.2 CCR6 ALB
21 cecal disease 10.2 CCR6 ALB
22 primary systemic mycosis 10.2 CCR6 ALB
23 autoimmune disease of urogenital tract 10.2 CCR6 ALB
24 pneumocystosis 10.2 CCR6 ALB
25 klebsiella pneumonia 10.2 CCR6 ALB
26 pyelitis 10.2 CCR6 ALB
27 eosinophilic gastroenteritis 10.2 CCR6 ALB
28 keratoconjunctivitis sicca 10.2 CCR6 ALB
29 hypersensitivity reaction type iii disease 10.2 CCR6 ALB
30 streptococcus pneumonia 10.2 CCR6 ALB
31 goodpasture syndrome 10.2 CCR6 ALB
32 autoimmune disease of peripheral nervous system 10.2 CCR6 ALB
33 parasitic ectoparasitic infectious disease 10.2 CCR6 ALB
34 cellulitis 10.2 CCR6 ALB
35 plasma protein metabolism disease 10.2 CCR6 ALB
36 diverticulitis 10.2 CCR6 ALB
37 perinatal necrotizing enterocolitis 10.2 CCR6 ALB
38 middle ear disease 10.2 CCR6 ALB
39 conjunctival disease 10.2 CCR6 ALB
40 splenic disease 10.2 CCR6 ALB
41 dysentery 10.2 CCR6 ALB
42 coccidiosis 10.2 CCR6 ALB
43 ureteral disease 10.2 CCR6 ALB
44 anus disease 10.2 CCR6 ALB
45 coronavirus infectious disease 10.2 CCR6 ALB
46 rheumatoid arthritis 10.2
47 syphilis 10.2 CCR6 ALB
48 rectal disease 10.2 CCR6 ALB
49 opportunistic mycosis 10.2 CCR6 ALB
50 nasal cavity disease 10.2 CCR6 ALB

Graphical network of the top 20 diseases related to Yellow Nail Syndrome:



Diseases related to Yellow Nail Syndrome

Symptoms & Phenotypes for Yellow Nail Syndrome

Human phenotypes related to Yellow Nail Syndrome:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0001004
2 fingernail dysplasia 58 31 hallmark (90%) Very frequent (99-80%) HP:0100798
3 bronchiectasis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002110
4 toenail dysplasia 58 31 hallmark (90%) Very frequent (99-80%) HP:0100797
5 hypoplasia of lymphatic vessels 58 31 hallmark (90%) Very frequent (99-80%) HP:0003759
6 yellow nails 58 31 hallmark (90%) Very frequent (99-80%) HP:0011367
7 recurrent respiratory infections 58 31 frequent (33%) Frequent (79-30%) HP:0002205
8 sinusitis 58 31 frequent (33%) Frequent (79-30%) HP:0000246
9 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
10 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
11 pleuritis 58 31 frequent (33%) Frequent (79-30%) HP:0002102
12 rhinitis 58 31 frequent (33%) Frequent (79-30%) HP:0012384
13 generalized abnormality of skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0011354
14 nephropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000112
15 immunodeficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002721
16 sarcoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0100242
17 pulmonary arterial hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002092
18 neoplasm of the lung 58 31 occasional (7.5%) Occasional (29-5%) HP:0100526
19 biliary tract neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0100574
20 renal neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0009726
21 onycholysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001806
22 abnormal fingernail morphology 58 Very frequent (99-80%)
23 neoplasm 58 Occasional (29-5%)
24 abnormal toenail morphology 58 Very frequent (99-80%)
25 abnormality of the musculature 31 HP:0003011
26 slow-growing nails 31 HP:0008383
27 predominantly lower limb lymphedema 31 HP:0003550

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Skin Nails Hair Nails:
slow-growing nails
yellow nails
excessively curved nails

Muscle Soft Tissue:
lymphedema, predominantly in the lower limbs
onset of lymphedema around puberty
lymphography shows hypoplasia of the lymphatic vessels

Clinical features from OMIM®:

153300 (Updated 05-Apr-2021)

UMLS symptoms related to Yellow Nail Syndrome:


yellow nails

MGI Mouse Phenotypes related to Yellow Nail Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 ADA ALB FOXC2 SOX18 SST
2 immune system MP:0005387 9.5 ADA ALB CCR6 ELK3 FOXC2 SOX18
3 normal MP:0002873 9.1 ADA ALB CCR6 FOXC2 SOX18 SST

Drugs & Therapeutics for Yellow Nail Syndrome

Search Clinical Trials , NIH Clinical Center for Yellow Nail Syndrome

Cochrane evidence based reviews: yellow nail syndrome

Genetic Tests for Yellow Nail Syndrome

Anatomical Context for Yellow Nail Syndrome

MalaCards organs/tissues related to Yellow Nail Syndrome:

40
Lung, Skin, Liver, Breast

Publications for Yellow Nail Syndrome

Articles related to Yellow Nail Syndrome:

(show top 50) (show all 326)
# Title Authors PMID Year
1
Primary non-syndromic lymphoedema (Meige disease) is not caused by mutations in FOXC2. 57 61
18197197 2008
2
Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature. 61 57
17459037 2007
3
Yellow nail syndrome presenting as non-immune hydrops: second case report. 57 61
10861674 2000
4
Perinatal manifestations of maternal yellow nail syndrome. 57 61
1594340 1992
5
Yellow nail syndrome: with familiar primary hypoplasia of lymphatics, manifest late in life. 57 61
5933133 1966
6
THE "YELLOW NAIL" SYNDROME. 61 57
14140738 1964
7
Truncating mutations in FOXC2 cause multiple lymphedema syndromes. 57
11371511 2001
8
Unusual presentation of a man with recurrent chylous ascites. 61
33674287 2021
9
Pulmonary Manifestations of Skin Disorders in Children. 61
33228937 2021
10
Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil. 61
33746514 2021
11
An autopsy case report of yellow nail syndrome coincided with primary biliary cholangitis. 61
33511030 2021
12
Yellow nail syndrome and overlap syndrome of autoimmune hepatitis and cholangitis: A rare association or an atypical presentation? 61
32616323 2020
13
Anaesthesia and orphan diseases: Yellow nail syndrome. 61
32692084 2020
14
Characterization of Sinus Disease in Patients with Yellow Nail Syndrome. 61
31603343 2020
15
Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps. 61
31589812 2020
16
Nails: The Window to the Nose? Update on Yellow Nail Syndrome. 61
32363094 2020
17
Congenital yellow nail syndrome presenting with eyelid lymphedema and fetal hydrops. 61
31763423 2019
18
Yellow Nail Syndrome: A Rare Cause of Pleural Effusion. 61
30606631 2019
19
A Case-Control Study of the Lymphatic Phenotype of Yellow Nail Syndrome: Comment. 61
31517570 2019
20
Yellow nail syndrome following multiple orthopedic surgeries: a case report. 61
31256758 2019
21
Yellow nail syndrome: differentials and prognosis. 61
31264591 2019
22
Orphan Lung Diseases. 61
30955517 2019
23
Yellow nail syndrome resulting from cardiac mitral valve replacement. 61
30971303 2019
24
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. 61
30883972 2019
25
General review of titanium toxicity. 61
30854575 2019
26
Answer to Photo Quiz: Yellow nail syndrome with complete triad. 61
30895934 2019
27
Yellow nail syndrome with complete triad. 61
30895933 2019
28
Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation. 61
30210127 2019
29
Hereditary Yellow Nail without a Syndrome. 61
30888955 2019
30
Yellow nail syndrome. 61
30949001 2018
31
Yellow Nail Syndrome Complicating Coronary Artery Bypass Graft Surgery. 61
29540629 2018
32
Yellow nail syndrome with chylothorax after coronary artery bypass grafting. 61
30201014 2018
33
Effectiveness of clarithromycin in patients with yellow nail syndrome. 61
30111321 2018
34
A Case-Control Study of the Lymphatic Phenotype of Yellow Nail Syndrome. 61
30130162 2018
35
Yellow Nail Syndrome: A Mystery, Partially Solved. 61
30130157 2018
36
Hyperplasia of Lymphoid Follicles and Lymphangiectasia in the Parietal Pleura in Bucillamine-induced Yellow Nail Syndrome. 61
29434155 2018
37
Immunoglobulin replacement therapy for yellow nail syndrome. 61
29280506 2018
38
Yellow Nail Syndrome Presenting With a Pericardial Effusion: A Case Report and Review of the Literature. 61
29067826 2018
39
[Respiratory manifestations of yellow nail syndrome: report of two cases and literature review]. 61
29518849 2018
40
Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR. 61
29071205 2018
41
Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease. 61
30345138 2018
42
Yellow Nail Syndrome. 61
29271348 2017
43
Bucillamine-induced yellow nail syndrome. 61
29264101 2017
44
The Development of Yellow Nail Syndrome after the Implantation of a Permanent Cardiac Pacemaker. 61
28883248 2017
45
Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome. 61
28969652 2017
46
Using Sutton's Law: Yellow Nail Syndrome. 61
28502815 2017
47
Foxc2 influences alveolar epithelial cell differentiation during lung development. 61
28675425 2017
48
Persistent benign pleural effusion. 61
28479076 2017
49
Yellow nail syndrome: a case report and review of treatment options. 61
26257383 2017
50
Yellow nail syndrome: a review. 61
28241848 2017

Variations for Yellow Nail Syndrome

Expression for Yellow Nail Syndrome

Search GEO for disease gene expression data for Yellow Nail Syndrome.

Pathways for Yellow Nail Syndrome

GO Terms for Yellow Nail Syndrome

Biological processes related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood vessel development GO:0001568 9.26 SOX18 FOXC2
2 embryonic heart tube development GO:0035050 9.16 SOX18 FOXC2
3 lymphangiogenesis GO:0001946 8.96 SOX18 FOXC2
4 lymph vessel development GO:0001945 8.62 SOX18 FOXC2

Sources for Yellow Nail Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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