MCID: YLL001
MIFTS: 52

Yellow Nail Syndrome

Categories: Rare diseases, Skin diseases, Cardiovascular diseases, Respiratory diseases, Fetal diseases, Immune diseases

Aliases & Classifications for Yellow Nail Syndrome

MalaCards integrated aliases for Yellow Nail Syndrome:

Name: Yellow Nail Syndrome 57 12 76 53 59 75 44 15
Yns 57 53 59 75
Lymphedema with Yellow Nails 53 59
Lymphedema and Yellow Nails 57 75
Hereditary Lymphedema and Yellow Nails 73
Lymphedema-Yellow Nails 75
Lyyn 75

Characteristics:

Orphanet epidemiological data:

59
yellow nail syndrome
Age of onset: Adult; Age of death: elderly;

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
allelic disorders with overlapping phenotypes include hereditary lymphedema type ii , lymphedema and ptosis , and the lymphedema-distichiasis syndrome


HPO:

32
yellow nail syndrome:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Yellow Nail Syndrome

NIH Rare Diseases : 53 Yellow nail syndrome is a very rare disorder characterized by three features: yellow nail discoloration, respiratory problems, and lower limb swelling (lymphedema). It usually occurs in people over age 50 but can occur in younger people. In addition to being yellow, nails may lack a cuticle, grow very slowly, and become detached (onycholysis). Respiratory problems may include chronic cough, bronchiectasis, and pleural effusion.Chronic sinusitis may also occur. The cause of yellow nail syndrome remains unknown. It usually occurs on its own but is rarely associated with autoimmune disease, or lymphatic diseases or cancers. Some researchers have hypothesized that titanium may play a role in the development of yellow nail syndrome (for example, in dental or joint implants or other environmental exposures). Treatment addresses each symptom present. In some cases, yellow nail syndrome goes away on its own.

MalaCards based summary : Yellow Nail Syndrome, also known as yns, is related to protein-losing enteropathy and bronchitis, and has symptoms including yellow nails An important gene associated with Yellow Nail Syndrome is ALB (Albumin), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Miconazole and Tavaborole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver, and related phenotypes are recurrent respiratory infections and generalized abnormality of skin

Disease Ontology : 12 A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached.

OMIM : 57 Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007). (153300)

UniProtKB/Swiss-Prot : 75 Lymphedema-yellow nails: A disorder characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.

Wikipedia : 76 Yellow nail syndrome, also known as \"primary lymphedema associated with yellow nails and pleural... more...

Related Diseases for Yellow Nail Syndrome

Diseases related to Yellow Nail Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 protein-losing enteropathy 30.7 ALB CD79A
2 bronchitis 30.4 ALB CD40LG CD79A
3 lung lymphoma 30.0 CD40LG CD79A
4 myeloma, multiple 30.0 ALB CD40LG CD79A
5 ostertagiasis 10.8 ALB CD79A
6 dermatitis, atopic, 3 10.8 ALB CD79A
7 root caries 10.8 ALB CD79A
8 parotitis 10.8 ALB CD79A
9 orthostatic proteinuria 10.8 ALB CD79A
10 chronic graft versus host disease 10.8 ALB CD79A
11 focal dermal hypoplasia 10.8 ALB CD79A
12 cranio-facial dystonia 10.7 FOXC2 SOX18
13 colorado tick fever 10.7 ALB CD40LG
14 plasmodium malariae malaria 10.7 ALB CD40LG
15 fournier gangrene 10.7 ALB CD40LG
16 lymphedema, hereditary, ii 10.7 FOXC2 SOX18
17 esophageal varix 10.7 ALB SST
18 encapsulated thymoma 10.7 CD79A SST
19 ulcerative stomatitis 10.7 ALB CD79A
20 splenic disease 10.7 ALB CD40LG
21 aleutian mink disease 10.6 ALB CD40LG
22 transient arthritis 10.6 ALB CD40LG
23 selective igg deficiency disease 10.6 CD40LG CD79A
24 c1q nephropathy 10.6 CD40LG CD79A
25 meningovascular neurosyphilis 10.6 CD40LG CD79A
26 alpha chain disease 10.6 CD40LG CD79A
27 brill-zinsser disease 10.6 CD40LG CD79A
28 exudative glomerulonephritis 10.6 CD40LG CD79A
29 salpingo-oophoritis 10.6 CD40LG CD79A
30 early yaws 10.6 CD40LG CD79A
31 ventilation pneumonitis 10.6 CD40LG CD79A
32 chronic interstitial cystitis 10.6 CD40LG CD79A
33 axillary adenitis 10.6 CD40LG CD79A
34 cryofibrinogenemia 10.6 CD40LG CD79A
35 trichostrongyloidiasis 10.6 CD40LG CD79A
36 subacute bacterial endocarditis 10.6 CD40LG CD79A
37 kwashiorkor 10.6 ALB TF
38 heterophyiasis 10.6 CD40LG CD79A
39 immunoglobulin g deficiency 10.6 CD40LG CD79A
40 orbital granuloma 10.6 CD40LG CD79A
41 transient hypogammaglobulinemia of infancy 10.6 CD40LG CD79A
42 hyperglobulinemic purpura 10.6 CD40LG CD79A
43 gastroduodenitis 10.6 CD40LG CD79A
44 bacterial conjunctivitis 10.6 CD40LG CD79A
45 heavy chain disease 10.6 CD40LG CD79A
46 ophthalmia neonatorum 10.6 CD40LG CD79A
47 immunoglobulin a deficiency 1 10.6 CD40LG CD79A
48 parotid disease 10.6 CD40LG CD79A
49 cerebral arteritis 10.6 CD40LG CD79A
50 selective immunoglobulin deficiency disease 10.6 CD40LG CD79A

Graphical network of the top 20 diseases related to Yellow Nail Syndrome:



Diseases related to Yellow Nail Syndrome

Symptoms & Phenotypes for Yellow Nail Syndrome

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Nails:
yellow nails
slow-growing nails
excessively curved nails

Muscle Soft Tissue:
lymphedema, predominantly in the lower limbs
onset of lymphedema around puberty
lymphography shows hypoplasia of the lymphatic vessels


Clinical features from OMIM:

153300

Human phenotypes related to Yellow Nail Syndrome:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent respiratory infections 59 32 frequent (33%) Frequent (79-30%) HP:0002205
2 generalized abnormality of skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0011354
3 nephropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000112
4 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
5 immunodeficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002721
6 pulmonary arterial hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002092
7 yellow nails 59 32 hallmark (90%) Very frequent (99-80%) HP:0011367
8 sinusitis 59 32 frequent (33%) Frequent (79-30%) HP:0000246
9 lymphedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0001004
10 sarcoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0100242
11 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
12 neoplasm of the lung 59 32 occasional (7.5%) Occasional (29-5%) HP:0100526
13 biliary tract neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0100574
14 bronchiectasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002110
15 fingernail dysplasia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100798
16 renal neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0009726
17 pleuritis 59 32 frequent (33%) Frequent (79-30%) HP:0002102
18 toenail dysplasia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100797
19 onycholysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001806
20 rhinitis 59 32 frequent (33%) Frequent (79-30%) HP:0012384
21 hypoplasia of lymphatic vessels 59 32 hallmark (90%) Very frequent (99-80%) HP:0003759
22 neoplasm 59 Occasional (29-5%)
23 abnormality of the fingernails 59 Very frequent (99-80%)
24 abnormality of the musculature 32 HP:0003011
25 abnormality of the toenails 59 Very frequent (99-80%)
26 slow-growing nails 32 HP:0008383
27 predominantly lower limb lymphedema 32 HP:0003550

UMLS symptoms related to Yellow Nail Syndrome:


yellow nails

GenomeRNAi Phenotypes related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CD79A FOXC2 PES1 ALB ATP2A2

MGI Mouse Phenotypes related to Yellow Nail Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ALB ATP2A2 CD40LG CD79A CYS1 FOXC2
2 digestive/alimentary MP:0005381 9.8 SST ALB ATP2A2 CYS1 FOXC2 SOX18
3 immune system MP:0005387 9.76 ATP2A2 CD40LG CD79A CYS1 FOXC2 LEF1
4 mortality/aging MP:0010768 9.65 CD40LG CYS1 FOXC2 LEF1 PES1 SOX18
5 renal/urinary system MP:0005367 9.1 ALB ATP2A2 CD40LG CD79A CYS1 FOXC2

Drugs & Therapeutics for Yellow Nail Syndrome

Drugs for Yellow Nail Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Tavaborole Approved, Investigational Phase 3 174671-46-6
3 Antifungal Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
2 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle

Search NIH Clinical Center for Yellow Nail Syndrome

Cochrane evidence based reviews: yellow nail syndrome

Genetic Tests for Yellow Nail Syndrome

Anatomical Context for Yellow Nail Syndrome

MalaCards organs/tissues related to Yellow Nail Syndrome:

41
Skin, Lung, Liver, B Cells

Publications for Yellow Nail Syndrome

Articles related to Yellow Nail Syndrome:

(show top 50) (show all 196)
# Title Authors Year
1
Hyperplasia of Lymphoid Follicles and Lymphangiectasia in the Parietal Pleura in Bucillamine-induced Yellow Nail Syndrome. ( 29434155 )
2018
2
Yellow Nail Syndrome Complicating Coronary Artery Bypass Graft Surgery. ( 29540629 )
2018
3
Yellow Nail Syndrome. ( 29271348 )
2017
4
Immunoglobulin replacement therapy for yellow nail syndrome. ( 29280506 )
2017
5
Yellow Nail Syndrome With Dramatic Improvement of Nail Manifestations After Endoscopic Sinus Surgery. ( 28979177 )
2017
6
Yellow nail syndrome: a review. ( 28241848 )
2017
7
Bucillamine-induced yellow nail syndrome. ( 29264101 )
2017
8
Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome. ( 27940507 )
2017
9
The Development of Yellow Nail Syndrome after the Implantation of a Permanent Cardiac Pacemaker. ( 28883248 )
2017
10
Using Sutton's law: yellow nail syndrome. ( 28502815 )
2017
11
Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome. ( 28969652 )
2017
12
Yellow Nail Syndrome Presenting With a Pericardial Effusion: A Case Report and Review of the Literature. ( 29067826 )
2017
13
Subungual Keratoacanthoma in a Patient With Yellow Nail Syndrome. ( 27158885 )
2016
14
Yellow nail syndrome. ( 26961110 )
2016
15
Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma. ( 27075800 )
2016
16
Relapse of Yellow Nail Syndrome with Pulmonary Lymphedema. ( 26781018 )
2016
17
Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs. ( 26989491 )
2016
18
Yellow Nail Syndrome. ( 28064275 )
2016
19
Titanium Pigment and Yellow Nail Syndrome. ( 27386465 )
2016
20
Case of yellow nail syndrome accompanied by nephrotic syndrome. ( 26704457 )
2016
21
Bronchiectasis in yellow nail syndrome. ( 27551950 )
2016
22
Thoracoscopy under Local Anesthesia was Useful for Diagnosing Yellow Nail Syndrome. ( 27086815 )
2016
23
Yellow Nail Syndrome: Report of a Case Successfully Treated with Octreotide. ( 26221155 )
2015
24
Role of Titanium in the Development of Yellow Nail Syndrome. ( 27172293 )
2015
25
The Way to a Man's Lungs Is through His Nails: Defining Yellow Nail Syndrome. ( 26285321 )
2015
26
Yellow Nail Syndrome Associated with Pericarditis and Pericardial Effusion: a Case Report. ( 26749238 )
2015
27
Yellow nail syndrome: a case report and review of treatment options. ( 26257383 )
2015
28
Titanium exposure and yellow nail syndrome. ( 26744684 )
2015
29
Yellow Nail Syndrome in Toenails. ( 26278312 )
2015
30
Dramatic improvement of yellow nail syndrome with a combination of intralesional triamcinolone, fluconazole, and sinusitis management. ( 26226835 )
2015
31
A curious case of yellow nail syndrome. ( 26016054 )
2015
32
Yellow Nail Syndrome and Nail Lichen Planus may be Induced by a Common Culprit. Focus on Dental Restorative Substances. ( 25593919 )
2014
33
Yellow nail syndrome: A rare entity. ( 25396153 )
2014
34
"You have a syndrome"-words you don't want to hear from a doctor. Battling yellow nail syndrome. ( 25422998 )
2014
35
Case-based discussion from North Tyneside General Hospital: somatostatin analogues in yellow nail syndrome associated with recurrent pleural effusions. ( 24923874 )
2014
36
Unusual manifestation of the yellow nail syndrome--case report. ( 24937826 )
2014
37
Video-assisted Thoracoscopic Decortication of Trapped Lung in a Patient With Yellow Nail Syndrome. ( 24419201 )
2014
38
Characteristics of patients with yellow nail syndrome and pleural effusion. ( 25123563 )
2014
39
Yellow nail syndrome: Clinical experience in a series of 21 patients. ( 24134631 )
2013
40
Yellow nail syndrome presenting with postpartum massive pleural effusion. ( 24279775 )
2013
41
Yellow nail syndrome. ( 24334596 )
2013
42
A 24 year-old male with yellow nail syndrome having bronchiactasis without pleural effusion as a pulmonary manifestation. ( 24469563 )
2013
43
Atypical presentation of congenital yellow nail syndrome in a 2-year-old female. ( 23364154 )
2013
44
Recurrent pleural effusion in yellow nail syndrome successfully treated with video-assisted thoracic surgery: comparison of two surgical strategies in two cases. ( 22763641 )
2013
45
T and B cell deficiency associated with yellow nail syndrome. ( 21995335 )
2012
46
Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. ( 22605706 )
2012
47
Yellow nails, lymphedema and chronic cough: yellow nail syndrome in an eight-year-old girl. ( 22332131 )
2012
48
Yellow nail syndrome: treatment of lymphedema using low pressure compression. ( 22416910 )
2012
49
Yellow nail syndrome with thoracic empyema: report of a case. ( 22143357 )
2012
50
Yellow nail syndrome. ( 22984032 )
2012

Variations for Yellow Nail Syndrome

Expression for Yellow Nail Syndrome

Search GEO for disease gene expression data for Yellow Nail Syndrome.

Pathways for Yellow Nail Syndrome

Pathways related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Yellow Nail Syndrome

Biological processes related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 branching involved in blood vessel morphogenesis GO:0001569 9.4 FOXC2 LEF1
2 vasculature development GO:0001944 9.37 LEF1 SOX18
3 embryonic heart tube development GO:0035050 9.32 FOXC2 SOX18
4 lymph vessel development GO:0001945 9.26 FOXC2 SOX18
5 lymphangiogenesis GO:0001946 9.16 FOXC2 SOX18
6 paraxial mesoderm formation GO:0048341 8.96 FOXC2 LEF1
7 B cell proliferation GO:0042100 8.8 CD40LG CD79A LEF1

Sources for Yellow Nail Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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