LYYN
MCID: YLL001
MIFTS: 48

Yellow Nail Syndrome (LYYN)

Categories: Cardiovascular diseases, Fetal diseases, Immune diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Yellow Nail Syndrome

MalaCards integrated aliases for Yellow Nail Syndrome:

Name: Yellow Nail Syndrome 57 12 76 53 59 75 44 15
Yns 57 53 59 75
Lymphedema with Yellow Nails 53 59
Lymphedema and Yellow Nails 57 75
Hereditary Lymphedema and Yellow Nails 73
Lymphedema-Yellow Nails 75
Lyyn 75

Characteristics:

Orphanet epidemiological data:

59
yellow nail syndrome
Age of onset: Adult; Age of death: elderly;

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
allelic disorders with overlapping phenotypes include hereditary lymphedema type ii , lymphedema and ptosis , and the lymphedema-distichiasis syndrome


HPO:

32
yellow nail syndrome:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Yellow Nail Syndrome

NIH Rare Diseases : 53 Yellow nail syndrome is a very rare disorder characterized by three features: yellow nail discoloration, respiratory problems, and lower limb swelling (lymphedema). It usually occurs in people over age 50, but can occur in younger people. In addition to being yellow, nails may lack a cuticle, grow very slowly, and become detached (onycholysis). Respiratory problems may include chronic cough, bronchiectasis, and pleural effusion.Chronic sinusitis may also occur. The cause of yellow nail syndrome remains unknown. It usually occurs on its own, but is sometimes associated with autoimmune disease, lymphatic diseases, or cancers. Some researchers have hypothesized that titanium may play a role in the development of yellow nail syndrome (for example, in dental or joint implants or other environmental exposures). Treatment addresses each symptom present. In some cases, yellow nail syndrome goes away on its own.

MalaCards based summary : Yellow Nail Syndrome, also known as yns, is related to lymphedema and rheumatoid arthritis, and has symptoms including yellow nails An important gene associated with Yellow Nail Syndrome is ALB (Albumin). The drugs Tavaborole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver, and related phenotypes are recurrent respiratory infections and generalized abnormality of skin

Disease Ontology : 12 A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached.

OMIM : 57 Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007). (153300)

UniProtKB/Swiss-Prot : 75 Lymphedema-yellow nails: A disorder characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.

Wikipedia : 76 Yellow nail syndrome, also known as "primary lymphedema associated with yellow nails and pleural... more...

Related Diseases for Yellow Nail Syndrome

Diseases related to Yellow Nail Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 lymphedema 30.9 FOXC2 SOX18
2 rheumatoid arthritis 10.3
3 arthritis 10.3
4 sinusitis 10.3
5 bronchiectasis 10.3
6 ascites, chylous 10.2
7 lichen planus 10.2
8 hereditary lymphedema 10.2 FOXC2 SOX18
9 pneumonia 10.2
10 hemopericardium 10.1
11 pericardial effusion 10.1
12 esophageal varix 10.1 ALB SST
13 epstein-barr virus hepatitis 10.1 ALB TF
14 lymphedema, hereditary, ii 10.1 FOXC2 SOX18
15 marasmus 10.1 ALB TF
16 bronchitis 10.1
17 kwashiorkor 10.1 ALB TF
18 venous malformations, multiple cutaneous and mucosal 10.1 FOXC2 SOX18
19 hepatic vascular disease 10.1 ALB SST
20 pure red-cell aplasia 10.1 ALB TF
21 encapsulated thymoma 10.1 MUC5B SST
22 ariboflavinosis 10.1 ALB TF
23 analbuminemia 10.1 ALB TF
24 vein disease 10.1 ALB SST
25 lipoid nephrosis 10.1 ALB TF
26 dysentery 10.1 ALB TF
27 protein-energy malnutrition 10.1 ALB TF
28 congenital lymphedema 10.1
29 cholelithiasis 10.1 ALB SST
30 upper respiratory tract disease 10.1 ALB MUC5B
31 pulmonary hemosiderosis 10.1 MUC5B TF
32 pancreas disease 10.1 ALB SST
33 lymphoma 10.1
34 pericarditis 10.1
35 testicular yolk sac tumor 10.1 ALB TF
36 chylothorax, congenital 10.0 ALB FOXC2 SST
37 chronic maxillary sinusitis 10.0 CYS1 MUC5B
38 klippel-trenaunay-weber syndrome 10.0 FOXC2 SOX18 SST
39 alcoholic liver cirrhosis 10.0 ALB TF
40 pericardium disease 10.0 ALB PES1
41 nutritional deficiency disease 10.0 ALB TF
42 pulmonary artery disease 10.0 ALB PES1
43 liver cirrhosis 9.9 ALB SST TF
44 wilson disease 9.9 ALB TF
45 breast cancer 9.9
46 renal cell carcinoma, nonpapillary 9.9
47 lung cancer 9.9
48 mycosis fungoides 9.9
49 myeloma, multiple 9.9
50 panbronchiolitis, diffuse 9.9

Graphical network of the top 20 diseases related to Yellow Nail Syndrome:



Diseases related to Yellow Nail Syndrome

Symptoms & Phenotypes for Yellow Nail Syndrome

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Nails:
yellow nails
slow-growing nails
excessively curved nails

Muscle Soft Tissue:
lymphedema, predominantly in the lower limbs
onset of lymphedema around puberty
lymphography shows hypoplasia of the lymphatic vessels


Clinical features from OMIM:

153300

Human phenotypes related to Yellow Nail Syndrome:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent respiratory infections 59 32 frequent (33%) Frequent (79-30%) HP:0002205
2 generalized abnormality of skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0011354
3 nephropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000112
4 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
5 immunodeficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002721
6 pulmonary arterial hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002092
7 yellow nails 59 32 hallmark (90%) Very frequent (99-80%) HP:0011367
8 sinusitis 59 32 frequent (33%) Frequent (79-30%) HP:0000246
9 lymphedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0001004
10 sarcoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0100242
11 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
12 neoplasm of the lung 59 32 occasional (7.5%) Occasional (29-5%) HP:0100526
13 biliary tract neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0100574
14 bronchiectasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002110
15 fingernail dysplasia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100798
16 renal neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0009726
17 pleuritis 59 32 frequent (33%) Frequent (79-30%) HP:0002102
18 toenail dysplasia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100797
19 onycholysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001806
20 rhinitis 59 32 frequent (33%) Frequent (79-30%) HP:0012384
21 hypoplasia of lymphatic vessels 59 32 hallmark (90%) Very frequent (99-80%) HP:0003759
22 neoplasm 59 Occasional (29-5%)
23 abnormality of the fingernails 59 Very frequent (99-80%)
24 abnormality of the musculature 32 HP:0003011
25 abnormal toenail morphology 59 Very frequent (99-80%)
26 slow-growing nails 32 HP:0008383
27 predominantly lower limb lymphedema 32 HP:0003550

UMLS symptoms related to Yellow Nail Syndrome:


yellow nails

MGI Mouse Phenotypes related to Yellow Nail Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 ATP2A2 CYS1 FOXC2 LEF1 MUC5B SOX18
2 digestive/alimentary MP:0005381 9.8 ALB ATP2A2 CYS1 FOXC2 SOX18 SST
3 homeostasis/metabolism MP:0005376 9.76 ALB ATP2A2 CYS1 FOXC2 MUC5B SOX18
4 immune system MP:0005387 9.5 ATP2A2 CYS1 FOXC2 LEF1 MUC5B SOX18
5 mortality/aging MP:0010768 9.32 ALB ATP2A2 CYS1 FOXC2 LEF1 MUC5B

Drugs & Therapeutics for Yellow Nail Syndrome

Drugs for Yellow Nail Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tavaborole Approved, Investigational Phase 3 174671-46-6
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Anti-Infective Agents Phase 3
4 Pharmaceutical Solutions Phase 3
5 Antifungal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
2 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle

Search NIH Clinical Center for Yellow Nail Syndrome

Cochrane evidence based reviews: yellow nail syndrome

Genetic Tests for Yellow Nail Syndrome

Anatomical Context for Yellow Nail Syndrome

MalaCards organs/tissues related to Yellow Nail Syndrome:

41
Skin, Lung, Liver, B Cells, Pancreas, Colon

Publications for Yellow Nail Syndrome

Articles related to Yellow Nail Syndrome:

(show top 50) (show all 209)
# Title Authors Year
1
Hyperplasia of Lymphoid Follicles and Lymphangiectasia in the Parietal Pleura in Bucillamine-induced Yellow Nail Syndrome. ( 29434155 )
2018
2
Yellow Nail Syndrome Complicating Coronary Artery Bypass Graft Surgery. ( 29540629 )
2018
3
Yellow Nail Syndrome Presenting With a Pericardial Effusion: A Case Report and Review of the Literature. ( 29067826 )
2018
4
Effectiveness of clarithromycin in patients with yellow nail syndrome. ( 30111321 )
2018
5
Yellow Nail Syndrome: A Mystery, Partially Solved. ( 30130157 )
2018
6
A Case-Control Study of the Lymphatic Phenotype of Yellow Nail Syndrome. ( 30130162 )
2018
7
Yellow nail syndrome with chylothorax after coronary artery bypass grafting. ( 30201014 )
2018
8
Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like pulmonary manifestation: Two case reports. ( 30210127 )
2018
9
Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease. ( 30345138 )
2018
10
Yellow Nail Syndrome. ( 29271348 )
2017
11
Immunoglobulin replacement therapy for yellow nail syndrome. ( 29280506 )
2017
12
Yellow Nail Syndrome With Dramatic Improvement of Nail Manifestations After Endoscopic Sinus Surgery. ( 28979177 )
2017
13
Yellow nail syndrome: a review. ( 28241848 )
2017
14
Bucillamine-induced yellow nail syndrome. ( 29264101 )
2017
15
Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome. ( 27940507 )
2017
16
The Development of Yellow Nail Syndrome after the Implantation of a Permanent Cardiac Pacemaker. ( 28883248 )
2017
17
Using Sutton's law: yellow nail syndrome. ( 28502815 )
2017
18
Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome. ( 28969652 )
2017
19
Biodegradation of pentachloronitrobenzene by Cupriavidus sp. YNS-85 and its potential for remediation of contaminated soils. ( 28238184 )
2017
20
Subungual Keratoacanthoma in a Patient With Yellow Nail Syndrome. ( 27158885 )
2016
21
Yellow nail syndrome. ( 26961110 )
2016
22
Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma. ( 27075800 )
2016
23
Relapse of Yellow Nail Syndrome with Pulmonary Lymphedema. ( 26781018 )
2016
24
Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs. ( 26989491 )
2016
25
Yellow Nail Syndrome. ( 28064275 )
2016
26
Titanium Pigment and Yellow Nail Syndrome. ( 27386465 )
2016
27
Case of yellow nail syndrome accompanied by nephrotic syndrome. ( 26704457 )
2016
28
Bronchiectasis in yellow nail syndrome. ( 27551950 )
2016
29
Thoracoscopy under Local Anesthesia was Useful for Diagnosing Yellow Nail Syndrome. ( 27086815 )
2016
30
Yellow Nail Syndrome: Report of a Case Successfully Treated with Octreotide. ( 26221155 )
2015
31
Role of Titanium in the Development of Yellow Nail Syndrome. ( 27172293 )
2015
32
The Way to a Man's Lungs Is through His Nails: Defining Yellow Nail Syndrome. ( 26285321 )
2015
33
Yellow Nail Syndrome Associated with Pericarditis and Pericardial Effusion: a Case Report. ( 26749238 )
2015
34
Yellow nail syndrome: a case report and review of treatment options. ( 26257383 )
2015
35
Titanium exposure and yellow nail syndrome. ( 26744684 )
2015
36
Yellow Nail Syndrome in Toenails. ( 26278312 )
2015
37
Dramatic improvement of yellow nail syndrome with a combination of intralesional triamcinolone, fluconazole, and sinusitis management. ( 26226835 )
2015
38
A curious case of yellow nail syndrome. ( 26016054 )
2015
39
Yellow Nail Syndrome and Nail Lichen Planus may be Induced by a Common Culprit. Focus on Dental Restorative Substances. ( 25593919 )
2014
40
Yellow nail syndrome: A rare entity. ( 25396153 )
2014
41
"You have a syndrome"-words you don't want to hear from a doctor. Battling yellow nail syndrome. ( 25422998 )
2014
42
Case-based discussion from North Tyneside General Hospital: somatostatin analogues in yellow nail syndrome associated with recurrent pleural effusions. ( 24923874 )
2014
43
Unusual manifestation of the yellow nail syndrome--case report. ( 24937826 )
2014
44
Video-assisted Thoracoscopic Decortication of Trapped Lung in a Patient With Yellow Nail Syndrome. ( 24419201 )
2014
45
Characteristics of patients with yellow nail syndrome and pleural effusion. ( 25123563 )
2014
46
Yellow nail syndrome: Clinical experience in a series of 21 patients. ( 24134631 )
2013
47
Yellow nail syndrome presenting with postpartum massive pleural effusion. ( 24279775 )
2013
48
Yellow nail syndrome. ( 24334596 )
2013
49
A 24 year-old male with yellow nail syndrome having bronchiactasis without pleural effusion as a pulmonary manifestation. ( 24469563 )
2013
50
Atypical presentation of congenital yellow nail syndrome in a 2-year-old female. ( 23364154 )
2013

Variations for Yellow Nail Syndrome

Expression for Yellow Nail Syndrome

Search GEO for disease gene expression data for Yellow Nail Syndrome.

Pathways for Yellow Nail Syndrome

GO Terms for Yellow Nail Syndrome

Biological processes related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somitogenesis GO:0001756 9.46 FOXC2 LEF1
2 blood vessel development GO:0001568 9.43 FOXC2 SOX18
3 retina homeostasis GO:0001895 9.4 ALB TF
4 branching involved in blood vessel morphogenesis GO:0001569 9.37 FOXC2 LEF1
5 vasculature development GO:0001944 9.32 LEF1 SOX18
6 embryonic heart tube development GO:0035050 9.26 FOXC2 SOX18
7 lymph vessel development GO:0001945 9.16 FOXC2 SOX18
8 lymphangiogenesis GO:0001946 8.96 FOXC2 SOX18
9 paraxial mesoderm formation GO:0048341 8.62 FOXC2 LEF1

Molecular functions related to Yellow Nail Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.8 FOXC2 LEF1 SOX18

Sources for Yellow Nail Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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