MCID: YTB001
MIFTS: 7

Yt Blood Group Antigen

Categories: Genetic diseases, Blood diseases

Aliases & Classifications for Yt Blood Group Antigen

MalaCards integrated aliases for Yt Blood Group Antigen:

Name: Yt Blood Group Antigen 57
Cartwright Antigen 57

Classifications:



External Ids:

OMIM 57 112100

Summaries for Yt Blood Group Antigen

OMIM : 57 The antibody defining the very common antigen Yt(a) was the cause of a cross-matching difficulty investigated by Eaton et al. (1956). It was presumed to be the result of previous transfusions. Among 1,051 English people, 4 negatives were found. Positives showed 2 grades of strength of reaction; on the assumption that the weaker reactors represented heterozygotes, an estimate of gene frequency simply by counting was possible. Telen et al. (1990) found that the Yt (Cartwright) red cell antigen resided on an unidentified phosphatidylinositol (PI)-linked protein. Telen and Whitsett (1992) identified a patient with the hitherto unreported Yt(a-b-) phenotype in whom studies allowed localization of the Yt antigens to the acetylcholinesterase molecule. Telen and Whitsett (1992) found that binding of antibodies to several membrane proteins including CD55 (125240), CD58 (153420), and CD59 (107271) were normal, whereas 4 monoclonal antibodies to different acetylcholinesterase epitopes reacted only weakly with Yt(a-b-) erythrocytes. In addition, enzymatic assay of acetylcholinesterase activity of Yt(a-b-) erythrocytes demonstrated only 15% of the normal amount of enzyme activity. The use of anti-Yt(a) in radioimmunoprecipitation experiments demonstrated the expected 160 kD of the acetylcholinesterase molecule from normal erythrocyte membrane proteins, but not from Yt(a-b-) erythrocytes. Spring et al. (1992) obtained similar results. Thus, acetylcholinesterase is the PI-linked protein that represents the Yt antigen. (112100)

MalaCards based summary : Yt Blood Group Antigen, is also known as cartwright antigen. An important gene associated with Yt Blood Group Antigen is ACHE (Acetylcholinesterase (Cartwright Blood Group)).

Related Diseases for Yt Blood Group Antigen

Symptoms & Phenotypes for Yt Blood Group Antigen

Clinical features from OMIM:

112100

Drugs & Therapeutics for Yt Blood Group Antigen

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Genetic Tests for Yt Blood Group Antigen

Anatomical Context for Yt Blood Group Antigen

Publications for Yt Blood Group Antigen

Variations for Yt Blood Group Antigen

Expression for Yt Blood Group Antigen

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Pathways for Yt Blood Group Antigen

GO Terms for Yt Blood Group Antigen

Sources for Yt Blood Group Antigen

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