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MCID: ZKF001
MIFTS: 43

Zika Fever

Categories: Blood diseases, Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Zika Fever

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MalaCards integrated aliases for Zika Fever:

Name: Zika Fever 12 15
Zika Virus Infection 59 44 73
Zika Virus Disease 12 59
Zika Virus 43

Characteristics:

Orphanet epidemiological data:

59
zika virus disease
Inheritance: Not applicable; Prevalence: 1-5/10000 (Brazil); Age of onset: All ages; Age of death: adult;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0060478
ICD10 33 A92.8
MeSH 44 D000071243
Orphanet 59 ORPHA448237
ICD10 via Orphanet 34 U06
UMLS 73 C0276289
Sources

Summaries for Zika Fever

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MedlinePlus : 43 Zika is a virus that is spread mostly by mosquitoes. A pregnant mother can pass it to her baby during pregnancy or around the time of birth. It can spread through sexual contact. There have also been reports that the virus has spread through blood transfusions. There have been outbreaks of Zika virus in the United States, Africa, Southeast Asia, the Pacific Islands, parts of the Caribbean, and Central and South America. Most people who get the virus do not get sick. One in five people do get symptoms, which can include a fever, rash, joint pain, and conjunctivitis (pinkeye). Symptoms are usually mild, and start 2 to 7 days after being bitten by an infected mosquito. A blood test can tell whether you have the infection. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking acetaminophen might help. Zika can cause microcephaly (a serious birth defect of the brain) and other problems in babies whose mothers were infected while pregnant. The Centers for Disease Control and Prevention recommends that pregnant women do not travel to areas where there is a Zika virus outbreak. If you do decide to travel, first talk to your doctor. You should also be careful to prevent mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Zika Fever, also known as zika virus infection, is related to japanese encephalitis and zika virus infection, and has symptoms including fever, headaches and joint pain. An important gene associated with Zika Fever is PURA (Purine Rich Element Binding Protein A), and among its related pathways/superpathways is Type II interferon signaling (IFNG). The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye.

Disease Ontology : 12 A viral infectious disease that has_material_basis in Zika virus, which is transmitted by Aedes aegypti mosquitoes and targets neural progenitor cells and neuronal cells in all stages of maturity and has symptom fever, has symptom rash, has symptom headaches and has symptom joint pain.

Wikipedia : 76 Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika... more...

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Related Diseases for Zika Fever

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Diseases related to Zika Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 30.1 IFNB1 STAT1
2 zika virus infection 11.3
3 zika virus congenital syndrome 11.2
4 noonan syndrome 5 10.5
5 dengue virus 10.5
6 encephalitis 10.3
7 rubella 10.2
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
9 fanconi anemia, complementation group c 10.2 NDUFA6 STAT1
10 anxiety 10.2
11 dengue disease 10.2
12 thrombocytopenia 10.2
13 congenital toxoplasmosis 10.2
14 neuropathy 10.2
15 toxoplasmosis 10.2
16 bladder neck obstruction 10.1 F3 PURA
17 infectious anterior uveitis 10.1 MRAP STAT1
18 diffuse pulmonary fibrosis 10.1 AQP5 MRAP
19 bone epithelioid hemangioma 10.1 EWSR1 F3
20 meningoencephalitis 10.1
21 infertility 10.1
22 venezuelan equine encephalitis 10.1 IFNB1 STAT1
23 aortic valve insufficiency 10.1 MRAP SLC6A1
24 microcephaly 10.1
25 guillain-barre syndrome 10.1
26 transient arthritis 10.1 F3 MRAP
27 microphthalmia with limb anomalies 10.1 IFNB1 STAT1
28 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.1 IFNB1 STAT1
29 male infertility 10.1
30 glaucoma 3, primary congenital, a 10.1
31 neuroblastoma 10.1
32 stroke, ischemic 10.1
33 dermatitis, atopic 10.1
34 spinal cord injury 10.1
35 uveitis 10.1
36 epilepsy 10.1
37 optic nerve disease 10.1
38 dermatitis 10.1
39 myelitis 10.1
40 purpura 10.1
41 acute disseminated encephalomyelitis 10.1
42 psoriasis 10.1
43 yellow fever 10.1
44 depression 10.1
45 seizure disorder 10.1
46 focal epithelial hyperplasia 10.1 IFNB1 NDUFA6
47 chikungunya 10.0
48 congenital zika syndrome 10.0
49 severe acute respiratory syndrome 10.0 IFNB1 STAT1
50 schizophrenia 10.0

Graphical network of the top 20 diseases related to Zika Fever:



Diseases related to Zika Fever
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Symptoms & Phenotypes for Zika Fever

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Symptoms:

12
  • • fever
  • • headaches
  • • joint pain
  • • rash
Sources

Drugs & Therapeutics for Zika Fever

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Drugs for Zika Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2,Phase 1
2 Vaccines Phase 2,Phase 1
3 Hypolipidemic Agents Phase 2
4 Anti-Inflammatory Agents Phase 2
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
6 Anticholesteremic Agents Phase 2
7 Lipid Regulating Agents Phase 2
8 Antimetabolites Phase 2
9
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
10
Aluminum sulfate Approved Phase 1 10043-01-3
11 Pharmaceutical Solutions Phase 1
12 Antibodies, Blocking Phase 1
13 Rho(D) Immune Globulin Phase 1
14 Antibodies Phase 1
15 gamma-Globulins Phase 1
16 Immunoglobulins Phase 1
17 Immunoglobulins, Intravenous Phase 1
18 Antibodies, Monoclonal Phase 1
19
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
20
Polyestradiol phosphate Approved 28014-46-2
21 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
22
Lactitol Investigational 585-86-4 3871
23 Estradiol 17 beta-cypionate
24 Estradiol 3-benzoate
25 Contraceptive Agents
26 Hormones, Hormone Substitutes, and Hormone Antagonists
27 Estrogens
28 Hormone Antagonists
29 Hormones

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 Yellow Fever Vaccine on Statin/ Non Statin Subjects Recruiting NCT03116802 Phase 2 Stamaril (live attenuated yellow fever vaccine)
3 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Active, not recruiting NCT03110770 Phase 2
4 Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Completed NCT02996890 Phase 1
5 Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study Completed NCT02937233 Phase 1
6 ZIKA Vaccine in Naive Subjects Completed NCT02952833 Phase 1 Saline
7 A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. Completed NCT02963909 Phase 1
8 Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Completed NCT03425149 Phase 1
9 Study of GLS-5700 in Dengue Virus Seropositive Adults Completed NCT02887482 Phase 1
10 Study of GLS-5700 in Healthy Volunteers Completed NCT02809443 Phase 1
11 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
12 Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG) Recruiting NCT03624946 Phase 1
13 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
14 Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Recruiting NCT03611946 Phase 1
15 Safety, Immunogenicity and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Adult Participants Recruiting NCT03343626 Phase 1 Placebo
16 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in ZIKV Infected Patients Recruiting NCT03776695 Phase 1
17 Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans Recruiting NCT03776786 Phase 1
18 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Active, not recruiting NCT02840487 Phase 1
19 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults Active, not recruiting NCT02996461 Phase 1
20 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans Active, not recruiting NCT03443830 Phase 1 Tyzivumab
21 Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Active, not recruiting NCT03014089 Phase 1
22 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers Active, not recruiting NCT03356561 Phase 1
23 Zika Virus Infection's Pregnancy Consequences in French Department of America Unknown status NCT02916732
24 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Unknown status NCT02810210
25 Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection Completed NCT03679728
26 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
27 Zika Case Definition and Surveillance Study Completed NCT03158233
28 Zika and Microcephaly: Case-control Study Completed NCT02741882
29 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456 Not Applicable
30 Evaluation of the Clinical Performance of the ZIKV Detectâ„¢ 2.0 IgM Capture ELISA Completed NCT03776903
31 Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers Completed NCT02957344
32 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
33 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
34 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
35 Zika in Infants and Pregnancy (ZIP) Recruiting NCT02856984
36 Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Recruiting NCT03263195
37 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
38 ZIKAlliance Children Cohort (ZIKAllianceCH) Recruiting NCT03393286
39 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
40 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
41 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
42 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
43 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
44 Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome Recruiting NCT03227601 Not Applicable
45 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
46 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
47 Wolbachia Disease Impact in Medellin and Bello Recruiting NCT03631719
48 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
49 Identification of Host Factors of Norovirus Infections in Mini-Gut Model Recruiting NCT03342547 Not Applicable
50 Screening for LID Clinical Studies Unit Healthy Volunteer Protocols Recruiting NCT01386424

Search NIH Clinical Center for Zika Fever

Cochrane evidence based reviews: zika virus infection

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Genetic Tests for Zika Fever

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Anatomical Context for Zika Fever

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MalaCards organs/tissues related to Zika Fever:

41
Brain, Testes, Eye, T Cells, Kidney, Spinal Cord, Bone
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Publications for Zika Fever

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Articles related to Zika Fever:

(show top 50) (show all 704)
# Title Authors Year
1
Zika virus infection activates sting-dependent antiviral autophagy in the Drosophila brain. ( 30260713 )
2019
2
Cutaneous features of Zika virus infection: a clinicopathological overview. ( 30267436 )
2019
3
Epileptic spasms as the presenting seizure type in a patient with a new "O" of TORCH, congenital Zika virus infection. ( 30456170 )
2019
4
Zika Virus Infection, Pregnancy and Microcephaly. ( 29341036 )
2018
5
The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. ( 29428508 )
2018
6
Designing B- and T-cell multi-epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection. ( 29900580 )
2018
7
Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain. ( 29934091 )
2018
8
In Reply-Cardiac Compromise in Zika Virus Infection. ( 29395352 )
2018
9
Electrocardiographic Finding in Zika Virus Infection. ( 29907402 )
2018
10
Zika virus infection in Nicaraguan households. ( 29851968 )
2018
11
Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study. ( 29894797 )
2018
12
Congenital syndrome associated with Zika virus infection among live births in Brazil: a description of the distribution of reported and confirmed cases in 2015-2016. ( 29972474 )
2018
13
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome. ( 29732381 )
2018
14
Autoimmune neuroretinopathy and Zika virus infection. ( 29909123 )
2018
15
Zika virus infection elicits auto-antibodies to C1q. ( 29382894 )
2018
16
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )
2018
17
Does immunity after Zika virus infection cross-protect against dengue? ( 29389533 )
2018
18
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. ( 29447264 )
2018
19
Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. ( 29846381 )
2018
20
What we know and what we don't know about perinatal Zika virus infection: a systematic review. ( 29415586 )
2018
21
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. ( 29400709 )
2018
22
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection. ( 29899743 )
2018
23
Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda, 2014-2017. ( 29975185 )
2018
24
Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore. ( 29346272 )
2018
25
<i>PARP12</i> suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. ( 29921658 )
2018
26
Inhibition of Neurogenesis by Zika virus Infection. ( 29422006 )
2018
27
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells. ( 29395533 )
2018
28
Cardiac Compromise in Zika Virus Infection. ( 29397953 )
2018
29
Ophthalmologic Manifestations Associated With Zika Virus Infection. ( 29437049 )
2018
30
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients. ( 29912006 )
2018
31
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
32
Zika virus infection estimates, Mexico. ( 29875515 )
2018
33
Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States. ( 29372233 )
2018
34
In Reply-Electrocardiographic Finding in Zika Virus Infection. ( 29907401 )
2018
35
Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. ( 29844290 )
2018
36
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. ( 29967348 )
2018
37
Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. ( 29437050 )
2018
38
Generalized pustular psoriasis triggered by Zika virus infection. ( 29027743 )
2018
39
Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis. ( 29443111 )
2018
40
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. ( 29880824 )
2018
41
Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child. ( 29972576 )
2018
42
Auditory brainstem function in microcephaly related to Zika virus infection. ( 29352094 )
2018
43
Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. ( 29381706 )
2018
44
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection<i>In</i><i>Vitro</i>and in a Mouse Model. ( 29435494 )
2018
45
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. ( 29379210 )
2018
46
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs. ( 29405107 )
2018
47
Reply to: Zika Virus Infection, Pregnancy and Microcephaly. ( 29341037 )
2018
48
Prevalence of asymptomatic Zika virus infection: a systematic review. ( 29904223 )
2018
49
Case Report: Acute Transverse Myelitis after Zika Virus Infection. ( 30277201 )
2018
50
Experimental Zika virus infection in Aedes aegypti: Susceptibility, transmission & co-infection with dengue & chikungunya viruses. ( 29749366 )
2018
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Variations for Zika Fever

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Expression for Zika Fever

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Search GEO for disease gene expression data for Zika Fever.
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Pathways for Zika Fever

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Pathways related to Zika Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Type II interferon signaling (IFNG) 1
10.19 IFNB1 STAT1
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GO Terms for Zika Fever

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Biological processes related to Zika Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to interferon-beta GO:0035458 8.62 IFNB1 STAT1
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Sources for Zika Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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