MCID: ZKF001
MIFTS: 46

Zika Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Zika Fever

MalaCards integrated aliases for Zika Fever:

Name: Zika Fever 12 15
Zika Virus Infection 59 44 73
Zika Virus Disease 12 59
Zika Virus 43

Characteristics:

Orphanet epidemiological data:

59
zika virus disease
Inheritance: Not applicable; Prevalence: 1-5/10000 (Brazil); Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0060478
ICD10 33 A92.8
MeSH 44 D000071243
Orphanet 59 ORPHA448237
ICD10 via Orphanet 34 U06
UMLS 73 C0276289

Summaries for Zika Fever

MedlinePlus : 43 Zika is a virus that is spread mostly by mosquitoes. A pregnant mother can pass it to her baby during pregnancy or around the time of birth. It can spread through sexual contact. There have also been reports that the virus has spread through blood transfusions. There have been outbreaks of Zika virus in the United States, Africa, Southeast Asia, the Pacific Islands, parts of the Caribbean, and Central and South America. Most people who get the virus do not get sick. One in five people do get symptoms, which can include a fever, rash, joint pain, and conjunctivitis (pinkeye). Symptoms are usually mild, and start 2 to 7 days after being bitten by an infected mosquito. A blood test can tell whether you have the infection. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking acetaminophen might help. Zika can cause microcephaly (a serious birth defect of the brain) and other problems in babies whose mothers were infected while pregnant. The Centers for Disease Control and Prevention recommends that pregnant women do not travel to areas where there is a Zika virus outbreak. If you do decide to travel, first talk to your doctor. You should also be careful to prevent mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Zika Fever, also known as zika virus infection, is related to zika virus infection and salivary gland disease, and has symptoms including fever, rash and headaches. An important gene associated with Zika Fever is AQP5 (Aquaporin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. The drugs Vaccines and Anticholesteremic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that has_material_basis in Zika virus, which is transmitted by Aedes aegypti mosquitoes and targets neural progenitor cells and neuronal cells in all stages of maturity and has symptom fever, has symptom rash, has symptom headaches and has symptom joint pain.

Wikipedia : 76 Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika... more...

Related Diseases for Zika Fever

Diseases related to Zika Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 zika virus infection 11.1
2 salivary gland disease 10.1 AQP5 CD40LG
3 kyasanur forest disease 10.0 CD40LG RAF1
4 murray valley encephalitis 10.0 CD40LG RAF1
5 la crosse encephalitis 10.0 CD40LG IFNB1
6 congenital zika syndrome 9.9
7 neuroretinitis 9.9 CD40LG IFNB1
8 extrinsic cardiomyopathy 9.9 CD40LG IFNB1
9 dengue disease 9.9 CD40LG RAF1
10 secondary progressive multiple sclerosis 9.8 CD40LG IFNB1
11 venezuelan equine encephalitis 9.8 IFNB1 STAT1
12 chronic inflammatory demyelinating polyradiculoneuropathy 9.7 IFNB1 STAT1
13 japanese encephalitis 9.7 IFNB1 STAT1
14 chlamydia 9.7 CD40LG RAF1
15 microphthalmia with limb anomalies 9.7 IFNB1 STAT1
16 axillary adenitis 9.7 CD40LG STAT1
17 coccidioidomycosis 9.7 CD40LG STAT1
18 immunodeficiency 17 9.6 CD40LG STAT1
19 norwegian scabies 9.6 CD40LG STAT1
20 demyelinating disease 9.6 CD40LG IFNB1
21 progressive multifocal leukoencephalopathy 9.6 CD40LG STAT1
22 opportunistic mycosis 9.5 CD40LG STAT1
23 dengue hemorrhagic fever 9.5 CD40LG STAT1
24 central nervous system disease 9.5 CD40LG IFNB1
25 mumps 9.4 CD40LG STAT1
26 rabies 9.4 CD40LG STAT1
27 nervous system disease 9.2 CD40LG IFNB1
28 hepatitis c 9.2 IFNB1 RAF1 STAT1
29 severe acute respiratory syndrome 9.1 CD40LG IFNB1 STAT1
30 measles 9.1 CD40LG IFNB1 STAT1
31 viral infectious disease 9.1 CD40LG IFNB1 STAT1
32 ewing sarcoma 8.7 CD40LG IFNB1 STAT1

Graphical network of the top 20 diseases related to Zika Fever:



Diseases related to Zika Fever

Symptoms & Phenotypes for Zika Fever

Symptoms:

12
  • fever
  • rash
  • headaches
  • joint pain

MGI Mouse Phenotypes related to Zika Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.46 AQP5 CD40LG RAF1 STAT1
2 homeostasis/metabolism MP:0005376 9.35 AQP5 CD40LG IFNB1 RAF1 STAT1
3 skeleton MP:0005390 8.92 CD40LG IFNB1 RAF1 STAT1

Drugs & Therapeutics for Zika Fever

Drugs for Zika Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Anticholesteremic Agents Phase 2
3 Anti-Inflammatory Agents Phase 2
4 Antimetabolites Phase 2
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
6 Hypolipidemic Agents Phase 2
7 Lipid Regulating Agents Phase 2
8
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
9
Aluminum sulfate Approved Phase 1 10043-01-3
10 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Recruiting NCT03110770 Phase 2
3 Yellow Fever Vaccine on Statin/ Non Statin Subjects Recruiting NCT03116802 Phase 2 Stamaril (live attenuated yellow fever vaccine)
4 Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Active, not recruiting NCT03014089 Phase 1, Phase 2
5 Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Completed NCT02996890 Phase 1
6 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
7 Safety, Immunogenicity and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Adult Participants Recruiting NCT03343626 Phase 1 Placebo
8 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers Recruiting NCT03356561 Phase 1
9 Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study Active, not recruiting NCT02937233 Phase 1
10 ZIKA Vaccine in Naive Subjects Active, not recruiting NCT02952833 Phase 1 Saline
11 A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. Active, not recruiting NCT02963909 Phase 1
12 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Active, not recruiting NCT02840487 Phase 1
13 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults Active, not recruiting NCT02996461 Phase 1
14 Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Active, not recruiting NCT03425149 Phase 1
15 Study of GLS-5700 in Dengue Virus Seropositive Adults Active, not recruiting NCT02887482 Phase 1
16 Study of GLS-5700 in Healthy Volunteers Active, not recruiting NCT02809443 Phase 1
17 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Active, not recruiting NCT03055000 Phase 1
18 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans Enrolling by invitation NCT03443830 Phase 1 Tyzivumab
19 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
20 Zika Case Definition and Surveillance Study Completed NCT03158233
21 Zika and Microcephaly: Case-control Study Completed NCT02741882
22 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456 Not Applicable
23 Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers Completed NCT02957344
24 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
25 Zika Virus Infection's Pregnancy Consequences in French Department of America Recruiting NCT02916732
26 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Recruiting NCT02810210
27 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
28 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
29 Zika in Infants and Pregnancy (ZIP) Recruiting NCT02856984
30 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Recruiting NCT02831699
31 Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Recruiting NCT03263195
32 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
33 ZIKAlliance Children Cohort (ZIKAllianceCH) Recruiting NCT03393286
34 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
35 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
36 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
37 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
38 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
39 Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome Recruiting NCT03227601 Not Applicable
40 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
41 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
42 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
43 Identification of Host Factors of Norovirus Infections in Mini-Gut Model Recruiting NCT03342547 Not Applicable
44 Screening for LID Clinical Studies Unit Healthy Volunteer Protocols Recruiting NCT01386424
45 Persistence of Zika Virus in Semen After Acute Infection Active, not recruiting NCT02733796
46 Dermatologic Manifestations of Zika Virus Enrolling by invitation NCT03229421
47 Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome Enrolling by invitation NCT03330600 Not Applicable
48 Spatial Repellents for Arbovirus Control Enrolling by invitation NCT03553277 Not Applicable
49 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
50 World Mosquito Program Noumea - Human Sample Component Not yet recruiting NCT03552094

Search NIH Clinical Center for Zika Fever

Cochrane evidence based reviews: zika virus infection

Genetic Tests for Zika Fever

Anatomical Context for Zika Fever

MalaCards organs/tissues related to Zika Fever:

41
Brain, Eye, Testes, T Cells, Fetal Brain, B Cells, Liver

Publications for Zika Fever

Articles related to Zika Fever:

(show top 50) (show all 167)
# Title Authors Year
1
Zika Virus Infection, Pregnancy and Microcephaly. ( 29341036 )
2018
2
The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. ( 29428508 )
2018
3
Designing B- and T-cell multi-epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection. ( 29900580 )
2018
4
Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain. ( 29934091 )
2018
5
In Reply-Cardiac Compromise in Zika Virus Infection. ( 29395352 )
2018
6
Electrocardiographic Finding in Zika Virus Infection. ( 29907402 )
2018
7
Zika virus infection in Nicaraguan households. ( 29851968 )
2018
8
Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study. ( 29894797 )
2018
9
Congenital syndrome associated with Zika virus infection among live births in Brazil: a description of the distribution of reported and confirmed cases in 2015-2016. ( 29972474 )
2018
10
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome. ( 29732381 )
2018
11
Autoimmune neuroretinopathy and Zika virus infection. ( 29909123 )
2018
12
Zika virus infection elicits auto-antibodies to C1q. ( 29382894 )
2018
13
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )
2018
14
Does immunity after Zika virus infection cross-protect against dengue? ( 29389533 )
2018
15
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. ( 29447264 )
2018
16
Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. ( 29846381 )
2018
17
What we know and what we don't know about perinatal Zika virus infection: a systematic review. ( 29415586 )
2018
18
Incidence of Guillain-BarrAc syndrome among Zika virus infected cases: a report from Thailand. ( 29364400 )
2018
19
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. ( 29400709 )
2018
20
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection. ( 29899743 )
2018
21
Author Response: Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections: Emphasis on the Role of Neuroimaging in Screening, Prognostication, and Follow-Up. ( 29037966 )
2018
22
Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda, 2014-2017. ( 29975185 )
2018
23
Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore. ( 29346272 )
2018
24
<i>PARP12</i> suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. ( 29921658 )
2018
25
Inhibition of Neurogenesis by Zika virus Infection. ( 29422006 )
2018
26
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells. ( 29395533 )
2018
27
Cardiac Compromise in Zika Virus Infection. ( 29397953 )
2018
28
Ophthalmologic Manifestations Associated With Zika Virus Infection. ( 29437049 )
2018
29
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients. ( 29912006 )
2018
30
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
31
Zika virus infection estimates, Mexico. ( 29875515 )
2018
32
Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections. ( 29037967 )
2018
33
Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States. ( 29372233 )
2018
34
In Reply-Electrocardiographic Finding in Zika Virus Infection. ( 29907401 )
2018
35
Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. ( 29844290 )
2018
36
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. ( 29967348 )
2018
37
Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. ( 29437050 )
2018
38
Generalized pustular psoriasis triggered by Zika virus infection. ( 29027743 )
2018
39
Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis. ( 29443111 )
2018
40
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. ( 29880824 )
2018
41
Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child. ( 29972576 )
2018
42
Auditory brainstem function in microcephaly related to Zika virus infection. ( 29352094 )
2018
43
Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. ( 29381706 )
2018
44
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection<i>In</i><i>Vitro</i>and in a Mouse Model. ( 29435494 )
2018
45
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. ( 29379210 )
2018
46
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs. ( 29405107 )
2018
47
Reply to: Zika Virus Infection, Pregnancy and Microcephaly. ( 29341037 )
2018
48
Prevalence of asymptomatic Zika virus infection: a systematic review. ( 29904223 )
2018
49
Zika Virus Infection in Children. ( 29406975 )
2018
50
Acute and chronic neurological consequences of early-life Zika virus infection in mice. ( 29875203 )
2018

Variations for Zika Fever

Expression for Zika Fever

Search GEO for disease gene expression data for Zika Fever.

Pathways for Zika Fever

Pathways related to Zika Fever according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 CD40LG IFNB1 RAF1 STAT1
2
Show member pathways
12.57 IFNB1 RAF1 STAT1
3
Show member pathways
12.45 CD40LG RAF1 STAT1
4
Show member pathways
12.36 IFNB1 RAF1 STAT1
5
Show member pathways
12.18 CD40LG RAF1 STAT1
6
Show member pathways
12.06 IFNB1 RAF1 STAT1
7
Show member pathways
12.03 IFNB1 RAF1 STAT1
8
Show member pathways
11.73 RAF1 STAT1
9 11.7 IFNB1 STAT1
10
Show member pathways
11.68 RAF1 STAT1
11 11.64 RAF1 STAT1
12 11.58 IFNB1 RAF1
13 11.58 IFNB1 RAF1 STAT1
14 11.56 RAF1 STAT1
15
Show member pathways
11.51 RAF1 STAT1
16 11.34 RAF1 STAT1
17 11.3 RAF1 STAT1
18 11.08 RAF1 STAT1
19 11.08 IFNB1 RAF1 STAT1
20 10.92 IFNB1 RAF1 STAT1
21 10.89 IFNB1 STAT1

GO Terms for Zika Fever

Biological processes related to Zika Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.4 CD40LG STAT1
2 platelet activation GO:0030168 9.37 CD40LG RAF1
3 B cell differentiation GO:0030183 9.32 CD40LG IFNB1
4 type I interferon signaling pathway GO:0060337 9.26 IFNB1 STAT1
5 B cell proliferation GO:0042100 9.16 CD40LG IFNB1
6 regulation of type I interferon-mediated signaling pathway GO:0060338 8.96 IFNB1 STAT1
7 cellular response to interferon-beta GO:0035458 8.62 IFNB1 STAT1

Molecular functions related to Zika Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 CD40LG STAT1

Sources for Zika Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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