Zika Virus Congenital Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Zika Virus Congenital Syndrome

MalaCards integrated aliases for Zika Virus Congenital Syndrome:

Name: Zika Virus Congenital Syndrome ¹² ¹⁵

Zikv Congenital Infection ¹²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080180

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Summaries for Zika Virus Congenital Syndrome

Disease Ontology : ¹² A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has material basis in the acquisition of Zika virus infection in utero.

MalaCards based summary : Zika Virus Congenital Syndrome, also known as zikv congenital infection, is related to microcephaly and dengue virus. An important gene associated with Zika Virus Congenital Syndrome is ZBP1 (Z-DNA Binding Protein 1), and among its related pathways/superpathways are NF-kappaB Signaling and NOD-like receptor signaling pathway.

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Related Diseases for Zika Virus Congenital Syndrome

Diseases in the Congenital Zika Syndrome family:

Zika Virus Congenital Syndrome

Diseases related to Zika Virus Congenital Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)

#	Related Disease	Score	Top Affiliating Genes
1	microcephaly	10.3
2	dengue virus	10.0
3	hemiplegia	10.0
4	guillain-barre syndrome	10.0
5	epilepsy	10.0
6	yellow fever	10.0
7	congenital zika syndrome	10.0
8	hypertonia	10.0
9	hypotonia	10.0
10	spasticity	10.0
11	congenital amyoplasia	10.0
12	caspase 8 deficiency	9.7	RIPK3 RIPK1

Graphical network of the top 20 diseases related to Zika Virus Congenital Syndrome:

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Symptoms & Phenotypes for Zika Virus Congenital Syndrome

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Drugs & Therapeutics for Zika Virus Congenital Syndrome

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome	Completed	NCT03330600

Search NIH Clinical Center for Zika Virus Congenital Syndrome

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Genetic Tests for Zika Virus Congenital Syndrome

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Anatomical Context for Zika Virus Congenital Syndrome

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Publications for Zika Virus Congenital Syndrome

Articles related to Zika Virus Congenital Syndrome:

(show all 17)

#	Title	Authors	PMID	Year
1	Classification of the interictal state with hypsarrhythmia from Zika Virus Congenital Syndrome and of the ictal state from epilepsy in childhood without hypsarrhythmia in EEGs using entropy measures. ⁶¹	Rocha PL...da Silva AM	33010735	2020
2	Facing a new reality from the Zika Virus Congenital Syndrome: the families' perspective. ⁶¹	Mendes AG...Arruda LO	32997012	2020
3	Exploring the Genetic Predisposition to Zika Virus Congenital Syndrome. ⁶¹	de Barros PVM...de Oliveira JRM	32112648	2020
4	[Analysis of the concept of the Zika Virus congenital syndrome]. ⁶¹	Teixeira GA...Enders BC	32022196	2020
5	Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon. ⁶¹	de Oliveira CS...Vasconcelos PFDC	32952536	2020
6	Family fortresses in Zika Congenital Syndrome according to Betty Neuman. ⁶¹	Lima LHSS...Cavalcanti AMTS	32074238	2020
7	The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report. ⁶¹	Sulleiro E...Soriano-Arandes A	31096455	2019
8	Congenital Zika virus syndrome…what else? Two case reports of severe combined fetal pathologies. ⁶¹	Vouga M...Schaub B	30176812	2018
9	Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. ⁶¹	Schaub B...Baud D	30169227	2017
10	The phenotypic spectrum of congenital Zika syndrome. ⁶¹	Del Campo M...Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM	28328129	2017
11	Zika virus congenital syndrome, the new Z in TORCHZ? Prospects for diagnosis prevention and treatment. ⁶¹	Bryson Y	28027061	2017
12	Zika virus infection and congenital anomalies in the Americas: opportunities for regional action. ⁶¹	Larrandaburu M...Schuler-Faccini L	31384281	2017
13	Zika virus congenital syndrome: experimental models and clinical aspects. ⁶¹	Polonio CM...Peron JPS	28932235	2017
14	Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. ⁶¹	Melo AS...Tanuri A	27695855	2016
15	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. ⁶¹	Franca GV...Victora CG	27372398	2016
16	Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. ⁶¹	Ventura CV...Belfort R	27228275	2016
17	[Zika virus congenital syndrome]. ⁶¹	Eickmann SH...Silva PF	27462846	2016

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Genes for Zika Virus Congenital Syndrome

Genes related to Zika Virus Congenital Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZBP1	Z-DNA Binding Protein 1	Protein Coding	6	DISEASES inferred ¹⁵
2	SLC6A7	Solute Carrier Family 6 Member 7	Protein Coding	4.93	DISEASES inferred ¹⁵
3	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	4.92	DISEASES inferred ¹⁵
4	TBR1	T-Box Brain Transcription Factor 1	Protein Coding	4.9	DISEASES inferred ¹⁵
5	C1QTNF9	C1q And TNF Related 9	Protein Coding	4.79	DISEASES inferred ¹⁵
6	AIM2	Absent In Melanoma 2	Protein Coding	4.68	DISEASES inferred ¹⁵
7	ACOD1	Aconitate Decarboxylase 1	Protein Coding	4.66	DISEASES inferred ¹⁵
8	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	4.64	DISEASES inferred ¹⁵

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Variations for Zika Virus Congenital Syndrome

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Expression for Zika Virus Congenital Syndrome

Search GEO for disease gene expression data for Zika Virus Congenital Syndrome.

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Pathways for Zika Virus Congenital Syndrome

Pathways related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.01	RIPK3 RIPK1 AIM2
2	NOD-like receptor signaling pathway ³⁶	11.59	RIPK3 RIPK1 AIM2
3	TNF signaling pathway ³⁶	11.45	RIPK3 RIPK1
4	Cytosolic sensors of pathogen-associated DNA ⁶⁵ Show member pathways Cytosolic DNA-sensing pathway ³⁶ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁵ IkBA variant leads to EDA-ID ⁶⁵ IKBKB deficiency causes SCID ⁶⁵ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁵ IRF3 mediated activation of type 1 IFN ⁶⁵ IRF3-mediated induction of type I IFN ⁶⁵ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁵ Regulation by TREX1 ⁶⁵ Regulation of innate immune responses to cytosolic DNA ⁶⁵ RIP-mediated NFkB activation via ZBP1 ⁶⁵ STAT6-mediated induction of chemokines ⁶⁵ STING mediated induction of host immune responses ⁶⁵ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁵ TRAF6 mediated NF-kB activation ⁶⁵ ZBP1(DAI) mediated induction of type I IFNs ⁶⁵	11.43	ZBP1 RIPK3 RIPK1 AIM2
5	P38 MAPK Signaling Pathway (sino) ¹ Show member pathways P38 MAPK Signaling Pathway ⁶⁶	11.37	RIPK3 RIPK1
6	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	11.36	ZBP1 RIPK3 RIPK1
7	IKK complex recruitment mediated by RIP1 ⁶⁵	10.64	RIPK3 RIPK1

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GO Terms for Zika Virus Congenital Syndrome

Biological processes related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	9.83	ZBP1 RIPK3 RIPK1 AIM2
2	inflammatory response	GO:0006954	9.73	RIPK1 AIM2 ACOD1
3	defense response to virus	GO:0051607	9.69	ZBP1 RIPK3 ACOD1
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.63	RIPK3 RIPK1 AIM2
5	positive regulation of inflammatory response	GO:0050729	9.59	ZBP1 RIPK1
6	negative regulation of NF-kappaB transcription factor activity	GO:0032088	9.58	AIM2 ACOD1
7	apoptotic signaling pathway	GO:0097190	9.58	RIPK3 RIPK1
8	cellular response to hydrogen peroxide	GO:0070301	9.57	RIPK3 RIPK1
9	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.55	RIPK3 RIPK1
10	activation of innate immune response	GO:0002218	9.54	ZBP1 AIM2
11	cellular response to interferon-beta	GO:0035458	9.49	AIM2 ACOD1
12	necroptotic process	GO:0070266	9.48	RIPK3 RIPK1
13	pyroptosis	GO:0070269	9.43	ZBP1 AIM2
14	positive regulation of necrotic cell death	GO:0010940	9.4	RIPK3 RIPK1
15	amyloid fibril formation	GO:1990000	9.37	RIPK3 RIPK1
16	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.33	RIPK3 RIPK1 ACOD1
17	necroptotic signaling pathway	GO:0097527	9.32	RIPK3 RIPK1
18	programmed necrotic cell death	GO:0097300	9.26	RIPK3 RIPK1
19	programmed cell death	GO:0012501	9.13	ZBP1 RIPK3 RIPK1
20	positive regulation of necroptotic process	GO:0060545	8.8	ZBP1 RIPK3 RIPK1

Molecular functions related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.1	ZBP1 TBR1 RIPK3 RIPK1 C1QTNF9 AIM2

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Sources for Zika Virus Congenital Syndrome

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