MCID: ZKV002
MIFTS: 21

Zika Virus Congenital Syndrome

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Zika Virus Congenital Syndrome

MalaCards integrated aliases for Zika Virus Congenital Syndrome:

Name: Zika Virus Congenital Syndrome 12 15
Zikv Congenital Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080180

Summaries for Zika Virus Congenital Syndrome

Disease Ontology : 12 A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has material basis in the acquisition of Zika virus infection in utero.

MalaCards based summary : Zika Virus Congenital Syndrome, also known as zikv congenital infection, is related to microcephaly and dengue virus. An important gene associated with Zika Virus Congenital Syndrome is ZBP1 (Z-DNA Binding Protein 1), and among its related pathways/superpathways are NF-kappaB Signaling and NOD-like receptor signaling pathway.

Related Diseases for Zika Virus Congenital Syndrome

Diseases in the Congenital Zika Syndrome family:

Zika Virus Congenital Syndrome

Diseases related to Zika Virus Congenital Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 microcephaly 10.3
2 dengue virus 10.0
3 hemiplegia 10.0
4 guillain-barre syndrome 10.0
5 epilepsy 10.0
6 yellow fever 10.0
7 congenital zika syndrome 10.0
8 hypertonia 10.0
9 hypotonia 10.0
10 spasticity 10.0
11 congenital amyoplasia 10.0
12 caspase 8 deficiency 9.7 RIPK3 RIPK1

Graphical network of the top 20 diseases related to Zika Virus Congenital Syndrome:



Diseases related to Zika Virus Congenital Syndrome

Symptoms & Phenotypes for Zika Virus Congenital Syndrome

Drugs & Therapeutics for Zika Virus Congenital Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600

Search NIH Clinical Center for Zika Virus Congenital Syndrome

Genetic Tests for Zika Virus Congenital Syndrome

Anatomical Context for Zika Virus Congenital Syndrome

Publications for Zika Virus Congenital Syndrome

Articles related to Zika Virus Congenital Syndrome:

(show all 17)
# Title Authors PMID Year
1
Classification of the interictal state with hypsarrhythmia from Zika Virus Congenital Syndrome and of the ictal state from epilepsy in childhood without hypsarrhythmia in EEGs using entropy measures. 61
33010735 2020
2
Facing a new reality from the Zika Virus Congenital Syndrome: the families' perspective. 61
32997012 2020
3
Exploring the Genetic Predisposition to Zika Virus Congenital Syndrome. 61
32112648 2020
4
[Analysis of the concept of the Zika Virus congenital syndrome]. 61
32022196 2020
5
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon. 61
32952536 2020
6
Family fortresses in Zika Congenital Syndrome according to Betty Neuman. 61
32074238 2020
7
The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report. 61
31096455 2019
8
Congenital Zika virus syndrome…what else? Two case reports of severe combined fetal pathologies. 61
30176812 2018
9
Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. 61
30169227 2017
10
The phenotypic spectrum of congenital Zika syndrome. 61
28328129 2017
11
Zika virus congenital syndrome, the new Z in TORCHZ? Prospects for diagnosis prevention and treatment. 61
28027061 2017
12
Zika virus infection and congenital anomalies in the Americas: opportunities for regional action. 61
31384281 2017
13
Zika virus congenital syndrome: experimental models and clinical aspects. 61
28932235 2017
14
Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. 61
27695855 2016
15
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. 61
27372398 2016
16
Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. 61
27228275 2016
17
[Zika virus congenital syndrome]. 61
27462846 2016

Variations for Zika Virus Congenital Syndrome

Expression for Zika Virus Congenital Syndrome

Search GEO for disease gene expression data for Zika Virus Congenital Syndrome.

Pathways for Zika Virus Congenital Syndrome

GO Terms for Zika Virus Congenital Syndrome

Biological processes related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.83 ZBP1 RIPK3 RIPK1 AIM2
2 inflammatory response GO:0006954 9.73 RIPK1 AIM2 ACOD1
3 defense response to virus GO:0051607 9.69 ZBP1 RIPK3 ACOD1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 RIPK3 RIPK1 AIM2
5 positive regulation of inflammatory response GO:0050729 9.59 ZBP1 RIPK1
6 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.58 AIM2 ACOD1
7 apoptotic signaling pathway GO:0097190 9.58 RIPK3 RIPK1
8 cellular response to hydrogen peroxide GO:0070301 9.57 RIPK3 RIPK1
9 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.55 RIPK3 RIPK1
10 activation of innate immune response GO:0002218 9.54 ZBP1 AIM2
11 cellular response to interferon-beta GO:0035458 9.49 AIM2 ACOD1
12 necroptotic process GO:0070266 9.48 RIPK3 RIPK1
13 pyroptosis GO:0070269 9.43 ZBP1 AIM2
14 positive regulation of necrotic cell death GO:0010940 9.4 RIPK3 RIPK1
15 amyloid fibril formation GO:1990000 9.37 RIPK3 RIPK1
16 positive regulation of reactive oxygen species metabolic process GO:2000379 9.33 RIPK3 RIPK1 ACOD1
17 necroptotic signaling pathway GO:0097527 9.32 RIPK3 RIPK1
18 programmed necrotic cell death GO:0097300 9.26 RIPK3 RIPK1
19 programmed cell death GO:0012501 9.13 ZBP1 RIPK3 RIPK1
20 positive regulation of necroptotic process GO:0060545 8.8 ZBP1 RIPK3 RIPK1

Molecular functions related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 ZBP1 TBR1 RIPK3 RIPK1 C1QTNF9 AIM2

Sources for Zika Virus Congenital Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....