MCID: ZKV002
MIFTS: 17

Zika Virus Congenital Syndrome

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Zika Virus Congenital Syndrome

MalaCards integrated aliases for Zika Virus Congenital Syndrome:

Name: Zika Virus Congenital Syndrome 12 15
Zikv Congenital Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080180

Summaries for Zika Virus Congenital Syndrome

Disease Ontology : 12 A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has material basis in the acquisition of Zika virus infection in utero.

MalaCards based summary : Zika Virus Congenital Syndrome, also known as zikv congenital infection, is related to microcephaly and hydrocephalus, congenital, 1. An important gene associated with Zika Virus Congenital Syndrome is BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B).

Related Diseases for Zika Virus Congenital Syndrome

Diseases in the Congenital Zika Syndrome family:

Zika Virus Congenital Syndrome

Diseases related to Zika Virus Congenital Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 microcephaly 10.1
2 hydrocephalus, congenital, 1 10.0
3 dengue virus 10.0
4 alkuraya-kucinskas syndrome 10.0
5 hemiplegia 10.0
6 guillain-barre syndrome 10.0
7 yellow fever 10.0
8 congenital zika syndrome 10.0
9 hypertonia 10.0
10 hypotonia 10.0
11 spasticity 10.0
12 congenital amyoplasia 10.0
13 severe cutaneous adverse reaction 9.6 PAX6 CD40LG
14 uveal disease 9.6 PAX6 CD40LG
15 congenital nervous system abnormality 9.4 TBR1 PAX6
16 periventricular nodular heterotopia 9.3 TBR1 PAX6 BCL11B
17 primary autosomal recessive microcephaly 9.0 TBR1 PHC3 PAX6 BCL11B
18 retinitis pigmentosa 8.6 PHC3 PAX6 CD40LG BCL11B

Graphical network of the top 20 diseases related to Zika Virus Congenital Syndrome:



Diseases related to Zika Virus Congenital Syndrome

Symptoms & Phenotypes for Zika Virus Congenital Syndrome

Drugs & Therapeutics for Zika Virus Congenital Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600

Search NIH Clinical Center for Zika Virus Congenital Syndrome

Genetic Tests for Zika Virus Congenital Syndrome

Anatomical Context for Zika Virus Congenital Syndrome

Publications for Zika Virus Congenital Syndrome

Articles related to Zika Virus Congenital Syndrome:

(show all 12)
# Title Authors PMID Year
1
[Analysis of the concept of the Zika Virus congenital syndrome]. 61
32022196 2020
2
The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report. 61
31096455 2019
3
Congenital Zika virus syndrome…what else? Two case reports of severe combined fetal pathologies. 61
30176812 2018
4
Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. 61
30169227 2017
5
The phenotypic spectrum of congenital Zika syndrome. 61
28328129 2017
6
Zika virus congenital syndrome, the new Z in TORCHZ? Prospects for diagnosis prevention and treatment. 61
28027061 2017
7
Zika virus infection and congenital anomalies in the Americas: opportunities for regional action. 61
31384281 2017
8
Zika virus congenital syndrome: experimental models and clinical aspects. 61
28932235 2017
9
Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. 61
27695855 2016
10
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. 61
27372398 2016
11
Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. 61
27228275 2016
12
[Zika virus congenital syndrome]. 61
27462846 2016

Variations for Zika Virus Congenital Syndrome

Expression for Zika Virus Congenital Syndrome

Search GEO for disease gene expression data for Zika Virus Congenital Syndrome.

Pathways for Zika Virus Congenital Syndrome

GO Terms for Zika Virus Congenital Syndrome

Biological processes related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.16 PAX6 BCL11B
2 regulation of gene expression GO:0010468 9.13 TBR1 PAX6 BCL11B
3 commitment of neuronal cell to specific neuron type in forebrain GO:0021902 8.8 TBR1 PAX6 BCL11B

Molecular functions related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.13 TBR1 PAX6 BCL11B
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.8 TBR1 PAX6 BCL11B

Sources for Zika Virus Congenital Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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