Zika Virus Congenital Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Zika Virus Congenital Syndrome

MalaCards integrated aliases for Zika Virus Congenital Syndrome:

Name: Zika Virus Congenital Syndrome ¹¹ ¹⁴

Zikv Congenital Infection ¹¹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080180

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Summaries for Zika Virus Congenital Syndrome

Disease Ontology: ¹¹ A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has material basis in the acquisition of Zika virus infection in utero.

MalaCards based summary: Zika Virus Congenital Syndrome, also known as zikv congenital infection, is related to microcephaly and zika fever. An important gene associated with Zika Virus Congenital Syndrome is IFIT5 (Interferon Induced Protein With Tetratricopeptide Repeats 5), and among its related pathways/superpathways are Potential therapeutics for SARS and Host-pathogen interaction of human coronaviruses - interferon induction. Affiliated tissues include heart, and related phenotype is immune system.

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Related Diseases for Zika Virus Congenital Syndrome

Diseases in the Congenital Zika Syndrome family:

Zika Virus Congenital Syndrome

Diseases related to Zika Virus Congenital Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)

#	Related Disease	Score	Top Affiliating Genes
1	microcephaly	29.5	STIL KNL1 IFNAR1 CDK5RAP2 BCL11B
2	zika fever	10.6
3	guillain-barre syndrome, familial	10.0
4	hydrocephalus, congenital, 1	10.0
5	dengue virus	10.0
6	west syndrome	10.0
7	tooth agenesis	10.0
8	distal arthrogryposis	10.0
9	hemiplegia	10.0
10	dengue disease	10.0
11	guillain-barre syndrome	10.0
12	viral infectious disease	10.0
13	yellow fever	10.0
14	congenital zika syndrome	10.0
15	hypertonia	10.0
16	hypotonia	10.0
17	spasticity	10.0
18	microcephaly 10, primary, autosomal recessive	10.0	KNL1 CDK5RAP2
19	microcephaly 13, primary, autosomal recessive	10.0	KNL1 CDK5RAP2
20	immunodeficiency 27a	9.9	IFNLR1 IFNAR1
21	microcephaly 14, primary, autosomal recessive	9.9	STIL CDK5RAP2
22	microcephaly 17, primary, autosomal recessive	9.9	STIL CDK5RAP2
23	microlissencephaly	9.8	STIL CDK5RAP2
24	microcephaly 12, primary, autosomal recessive	9.7	STIL KNL1 CDK5RAP2
25	microcephaly 9, primary, autosomal recessive	9.7	STIL KNL1 CDK5RAP2
26	microcephaly 5, primary, autosomal recessive	9.7	STIL KNL1 CDK5RAP2
27	microcephalic osteodysplastic primordial dwarfism, type ii	9.7	STIL CDK5RAP2
28	primary microcephaly	9.7	STIL KNL1 CDK5RAP2
29	periventricular nodular heterotopia	9.7	STIL CDK5RAP2 BCL11B
30	seckel syndrome	9.7	STIL KNL1 CDK5RAP2
31	isolated growth hormone deficiency, type ia	9.6	STIL CDK5RAP2
32	primary autosomal recessive microcephaly	9.5	STIL KNL1 CDK5RAP2 BCL11B
33	congenital nervous system abnormality	9.3	STIL KNL1 IFNAR1 CDK5RAP2 BCL11B

Graphical network of the top 20 diseases related to Zika Virus Congenital Syndrome:

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Symptoms & Phenotypes for Zika Virus Congenital Syndrome

MGI Mouse Phenotypes related to Zika Virus Congenital Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.17	BCL11B CDK5RAP2 DISP3 IFNAR1 IFNLR1 KNL1

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Drugs & Therapeutics for Zika Virus Congenital Syndrome

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome	Completed	NCT03330600

Search NIH Clinical Center for Zika Virus Congenital Syndrome

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Genetic Tests for Zika Virus Congenital Syndrome

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Anatomical Context for Zika Virus Congenital Syndrome

Organs/tissues related to Zika Virus Congenital Syndrome:

MalaCards : Heart

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Publications for Zika Virus Congenital Syndrome

Articles related to Zika Virus Congenital Syndrome:

(show all 24)

#	Title	Authors	PMID	Year
1	First cases of oligodontia as a manifestation of the Zika virus congenital syndrome. ⁶²	da Costa CCG...Junior HM	36058836	2022
2	Discrimination of secondary hypsarrhythmias to Zika virus congenital syndrome and west syndrome based on joint moments and entropy measurements. ⁶²	Rocha PL...Barros AK	35513477	2022
3	Spatial Analysis of Notified Zika Virus Congenital Syndrome, Maranhão, 2015 to 2018. ⁶²	Falcao Neto PAO...Santos AMD	35170680	2022
4	Restoration of a malformed primary incisor using digital technology in a pediatric patient with congenital Zika virus syndrome: A case report. ⁶²	Carvalho IF...Sousa FB	35936937	2022
5	Congenital heart disease in Zika virus congenital syndrome: How and when to investigate. ⁶²	Arrais NMR...de Moraes-Pinto MI	34363633	2021
6	Zika Virus Congenital Syndrome and MTOR gene variants: insights from a family of dizygotic twins. ⁶²	de O da Silva LR...Figueiredo CA	33997407	2021
7	Persistence of Anti-ZIKV-IgG over Time Is Not a Useful Congenital Infection Marker in Infants Born to ZIKV-Infected Mothers: The NATZIG Cohort. ⁶²	Coutinho CM...For The Natzig Cohort Study Team	33924066	2021
8	Classification of the interictal state with hypsarrhythmia from Zika Virus Congenital Syndrome and of the ictal state from epilepsy in childhood without hypsarrhythmia in EEGs using entropy measures. ⁶²	Rocha PL...da Silva AM	33010735	2020
9	Facing a new reality from the Zika Virus Congenital Syndrome: the families' perspective. ⁶²	Mendes AG...Arruda LO	32997012	2020
10	Exploring the Genetic Predisposition to Zika Virus Congenital Syndrome. ⁶²	de Barros PVM...de Oliveira JRM	32112648	2020
11	[Analysis of the concept of the Zika Virus congenital syndrome]. ⁶²	Teixeira GA...Enders BC	32022196	2020
12	Family fortresses in Zika Congenital Syndrome according to Betty Neuman. ⁶²	Lima LHSS...Cavalcanti AMTS	32074238	2020
13	Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon. ⁶²	de Oliveira CS...Vasconcelos PFDC	32952536	2020
14	The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report. ⁶²	Sulleiro E...Soriano-Arandes A	31096455	2019
15	Congenital Zika virus syndrome…what else? Two case reports of severe combined fetal pathologies. ⁶²	Vouga M...Schaub B	30176812	2018
16	Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. ⁶²	Schaub B...Baud D	30169227	2017
17	The phenotypic spectrum of congenital Zika syndrome. ⁶²	Del Campo M...Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM	28328129	2017
18	Zika virus congenital syndrome, the new Z in TORCHZ? Prospects for diagnosis prevention and treatment. ⁶²	Bryson Y	28027061	2017
19	Zika virus infection and congenital anomalies in the Americas: opportunities for regional action. ⁶²	Larrandaburu M...Schuler-Faccini L	31384281	2017
20	Zika virus congenital syndrome: experimental models and clinical aspects. ⁶²	Polonio CM...Peron JPS	28932235	2017
21	Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. ⁶²	Melo AS...Tanuri A	27695855	2016
22	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. ⁶²	Franca GV...Victora CG	27372398	2016
23	Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. ⁶²	Ventura CV...Belfort R	27228275	2016
24	[Zika virus congenital syndrome]. ⁶²	Eickmann SH...Silva PF	27462846	2016

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Genes for Zika Virus Congenital Syndrome

Genes related to Zika Virus Congenital Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IFIT5	Interferon Induced Protein With Tetratricopeptide Repeats 5	Protein Coding	5.37	DISEASES inferred ¹⁴
2	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	5.01	DISEASES inferred ¹⁴
3	ZBP1	Z-DNA Binding Protein 1	Protein Coding	4.92	DISEASES inferred ¹⁴
4	KNL1	Kinetochore Scaffold 1	Protein Coding	4.84	DISEASES inferred ¹⁴
5	BCL11B	BCL11 Transcription Factor B	Protein Coding	4.76	DISEASES inferred ¹⁴
6	CDK5RAP2	CDK5 Regulatory Subunit Associated Protein 2	Protein Coding	4.72	DISEASES inferred ¹⁴
7	IFNLR1	Interferon Lambda Receptor 1	Protein Coding	4.59	DISEASES inferred ¹⁴
8	STIL	STIL Centriolar Assembly Protein	Protein Coding	4.58	DISEASES inferred ¹⁴
9	DISP3	Dispatched RND Transporter Family Member 3	Protein Coding	4.54	DISEASES inferred ¹⁴
10	GAGE2A	G Antigen 2A	Protein Coding	4.47	DISEASES inferred ¹⁴

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Variations for Zika Virus Congenital Syndrome

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Expression for Zika Virus Congenital Syndrome

Search GEO for disease gene expression data for Zika Virus Congenital Syndrome.

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Pathways for Zika Virus Congenital Syndrome

Pathways related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Potential therapeutics for SARS ⁶⁶	10.95	ZBP1 IFNAR1
2	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	10.6	IFNLR1 IFNAR1

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GO Terms for Zika Virus Congenital Syndrome

Biological processes related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to virus	GO:0051607	9.63	ZBP1 IFNLR1 IFIT5
2	regulation of neuron differentiation	GO:0045664	9.26	CDK5RAP2 BCL11B
3	positive regulation of cellular respiration	GO:1901857	8.92	IFNLR1 IFNAR1

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Sources for Zika Virus Congenital Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ZKV002 MIFTS: 21	Zika Virus Congenital Syndrome Categories: Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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