MCID: ZKV002
MIFTS: 21

Zika Virus Congenital Syndrome

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Zika Virus Congenital Syndrome

MalaCards integrated aliases for Zika Virus Congenital Syndrome:

Name: Zika Virus Congenital Syndrome 11 14
Zikv Congenital Infection 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0080180

Summaries for Zika Virus Congenital Syndrome

Disease Ontology: 11 A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has material basis in the acquisition of Zika virus infection in utero.

MalaCards based summary: Zika Virus Congenital Syndrome, also known as zikv congenital infection, is related to microcephaly and zika fever. An important gene associated with Zika Virus Congenital Syndrome is IFIT5 (Interferon Induced Protein With Tetratricopeptide Repeats 5), and among its related pathways/superpathways are Potential therapeutics for SARS and Host-pathogen interaction of human coronaviruses - interferon induction. Affiliated tissues include heart, and related phenotype is immune system.

Related Diseases for Zika Virus Congenital Syndrome

Diseases in the Congenital Zika Syndrome family:

Zika Virus Congenital Syndrome

Diseases related to Zika Virus Congenital Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 microcephaly 29.5 STIL KNL1 IFNAR1 CDK5RAP2 BCL11B
2 zika fever 10.6
3 guillain-barre syndrome, familial 10.0
4 hydrocephalus, congenital, 1 10.0
5 dengue virus 10.0
6 west syndrome 10.0
7 tooth agenesis 10.0
8 distal arthrogryposis 10.0
9 hemiplegia 10.0
10 dengue disease 10.0
11 guillain-barre syndrome 10.0
12 viral infectious disease 10.0
13 yellow fever 10.0
14 congenital zika syndrome 10.0
15 hypertonia 10.0
16 hypotonia 10.0
17 spasticity 10.0
18 microcephaly 10, primary, autosomal recessive 10.0 KNL1 CDK5RAP2
19 microcephaly 13, primary, autosomal recessive 10.0 KNL1 CDK5RAP2
20 immunodeficiency 27a 9.9 IFNLR1 IFNAR1
21 microcephaly 14, primary, autosomal recessive 9.9 STIL CDK5RAP2
22 microcephaly 17, primary, autosomal recessive 9.9 STIL CDK5RAP2
23 microlissencephaly 9.8 STIL CDK5RAP2
24 microcephaly 12, primary, autosomal recessive 9.7 STIL KNL1 CDK5RAP2
25 microcephaly 9, primary, autosomal recessive 9.7 STIL KNL1 CDK5RAP2
26 microcephaly 5, primary, autosomal recessive 9.7 STIL KNL1 CDK5RAP2
27 microcephalic osteodysplastic primordial dwarfism, type ii 9.7 STIL CDK5RAP2
28 primary microcephaly 9.7 STIL KNL1 CDK5RAP2
29 periventricular nodular heterotopia 9.7 STIL CDK5RAP2 BCL11B
30 seckel syndrome 9.7 STIL KNL1 CDK5RAP2
31 isolated growth hormone deficiency, type ia 9.6 STIL CDK5RAP2
32 primary autosomal recessive microcephaly 9.5 STIL KNL1 CDK5RAP2 BCL11B
33 congenital nervous system abnormality 9.3 STIL KNL1 IFNAR1 CDK5RAP2 BCL11B

Graphical network of the top 20 diseases related to Zika Virus Congenital Syndrome:



Diseases related to Zika Virus Congenital Syndrome

Symptoms & Phenotypes for Zika Virus Congenital Syndrome

MGI Mouse Phenotypes related to Zika Virus Congenital Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 BCL11B CDK5RAP2 DISP3 IFNAR1 IFNLR1 KNL1

Drugs & Therapeutics for Zika Virus Congenital Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600

Search NIH Clinical Center for Zika Virus Congenital Syndrome

Genetic Tests for Zika Virus Congenital Syndrome

Anatomical Context for Zika Virus Congenital Syndrome

Organs/tissues related to Zika Virus Congenital Syndrome:

MalaCards : Heart

Publications for Zika Virus Congenital Syndrome

Articles related to Zika Virus Congenital Syndrome:

(show all 24)
# Title Authors PMID Year
1
First cases of oligodontia as a manifestation of the Zika virus congenital syndrome. 62
36058836 2022
2
Discrimination of secondary hypsarrhythmias to Zika virus congenital syndrome and west syndrome based on joint moments and entropy measurements. 62
35513477 2022
3
Spatial Analysis of Notified Zika Virus Congenital Syndrome, Maranhão, 2015 to 2018. 62
35170680 2022
4
Restoration of a malformed primary incisor using digital technology in a pediatric patient with congenital Zika virus syndrome: A case report. 62
35936937 2022
5
Congenital heart disease in Zika virus congenital syndrome: How and when to investigate. 62
34363633 2021
6
Zika Virus Congenital Syndrome and MTOR gene variants: insights from a family of dizygotic twins. 62
33997407 2021
7
Persistence of Anti-ZIKV-IgG over Time Is Not a Useful Congenital Infection Marker in Infants Born to ZIKV-Infected Mothers: The NATZIG Cohort. 62
33924066 2021
8
Classification of the interictal state with hypsarrhythmia from Zika Virus Congenital Syndrome and of the ictal state from epilepsy in childhood without hypsarrhythmia in EEGs using entropy measures. 62
33010735 2020
9
Facing a new reality from the Zika Virus Congenital Syndrome: the families' perspective. 62
32997012 2020
10
Exploring the Genetic Predisposition to Zika Virus Congenital Syndrome. 62
32112648 2020
11
[Analysis of the concept of the Zika Virus congenital syndrome]. 62
32022196 2020
12
Family fortresses in Zika Congenital Syndrome according to Betty Neuman. 62
32074238 2020
13
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon. 62
32952536 2020
14
The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report. 62
31096455 2019
15
Congenital Zika virus syndrome…what else? Two case reports of severe combined fetal pathologies. 62
30176812 2018
16
Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. 62
30169227 2017
17
The phenotypic spectrum of congenital Zika syndrome. 62
28328129 2017
18
Zika virus congenital syndrome, the new Z in TORCHZ? Prospects for diagnosis prevention and treatment. 62
28027061 2017
19
Zika virus infection and congenital anomalies in the Americas: opportunities for regional action. 62
31384281 2017
20
Zika virus congenital syndrome: experimental models and clinical aspects. 62
28932235 2017
21
Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. 62
27695855 2016
22
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. 62
27372398 2016
23
Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. 62
27228275 2016
24
[Zika virus congenital syndrome]. 62
27462846 2016

Variations for Zika Virus Congenital Syndrome

Expression for Zika Virus Congenital Syndrome

Search GEO for disease gene expression data for Zika Virus Congenital Syndrome.

Pathways for Zika Virus Congenital Syndrome

GO Terms for Zika Virus Congenital Syndrome

Biological processes related to Zika Virus Congenital Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.63 ZBP1 IFNLR1 IFIT5
2 regulation of neuron differentiation GO:0045664 9.26 CDK5RAP2 BCL11B
3 positive regulation of cellular respiration GO:1901857 8.92 IFNLR1 IFNAR1

Sources for Zika Virus Congenital Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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