Zika Virus Infection

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Zika Virus Infection

MalaCards integrated aliases for Zika Virus Infection:

Name: Zika Virus Infection 53 3 72
Zika Virus Disease 53
Zika Fever 53


External Ids:

UMLS 72 C0276289

Summaries for Zika Virus Infection

NIH Rare Diseases : 53 Zika virus infection is spread to people primarily through the bite of an infected mosquito. Zika virus can also be spread from a pregnant mother to her child and through sexual contact with an affected partner. Cases of Zika virus transmission via blood transfusion have also been reported. Zika virus outbreaks are currently occurring in many countries. The illness associated with Zika virus infection is usually mild, with symptoms lasting for several days to a week. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). However, research has suggested an association between Zika virus infection and Guillain-Barre syndrome (GBS) in a small percentage of cases. Zika virus infection during pregnancy can cause adverse pregnancy outcomes, including microcephaly and other serious brain defects. The full range of health problems associated with Zika virus infection during pregnancy is currently being studied. No vaccine currently exists to prevent Zika virus infection, but there are still ways to protect oneself. The CDC recommends that pregnant women consider postponing travel to Zika-affected areas. People living in or traveling to areas where Zika virus is found should take steps to prevent mosquito bites. Those who have traveled to Zika-affected areas may wish to take steps to prevent sexual transmission of the Zika virus.

MalaCards based summary : Zika Virus Infection, also known as zika virus disease, is related to zika fever and congenital zika syndrome. An important gene associated with Zika Virus Infection is AXL (AXL Receptor Tyrosine Kinase), and among its related pathways/superpathways are Glioma and Cellular senescence (KEGG). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

CDC : 3 Zika is spread mostly by the bite of an infected Aedes species mosquito (Ae. aegypti and Ae. albopictus). These mosquitoes bite during the day and night. Zika can be passed from a pregnant woman to her fetus. Infection during pregnancy can cause certain birth defects. There is no vaccine or medicine for Zika.

Related Diseases for Zika Virus Infection

Diseases related to Zika Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 zika fever 12.2
2 congenital zika syndrome 11.8
3 zika virus congenital syndrome 11.7
4 microcephaly 11.2
5 guillain-barre syndrome 11.0
6 dengue virus 10.9
7 exanthem 10.9
8 chikungunya 10.7
9 conjunctivitis 10.7
10 yellow fever 10.6
11 hydrocephalus, congenital, 1 10.6
12 myelitis 10.5
13 west nile virus 10.5
14 alkuraya-kucinskas syndrome 10.5
15 congenital amyoplasia 10.5
16 encephalitis 10.5
17 dengue disease 10.4
18 meningoencephalitis 10.4
19 thrombocytopenia 10.4
20 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
21 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
22 tick-borne encephalitis 10.3
23 japanese encephalitis 10.3
24 hydrocephalus 10.3
25 rubella 10.3
26 toxoplasmosis 10.3
27 congenital hydrocephalus 10.3
28 cytokine deficiency 10.3
29 uveitis 10.3
30 polyneuropathy 10.3
31 acute disseminated encephalomyelitis 10.3
32 autoimmune disease 10.2
33 neural tube defects 10.2
34 neuroblastoma 1 10.2
35 lissencephaly 10.2
36 cerebral palsy 10.2
37 measles 10.2
38 neuropathy 10.2
39 bacterial conjunctivitis 10.2
40 cerebellar hypoplasia 10.2
41 yemenite deaf-blind hypopigmentation syndrome 10.2
42 hepatitis c virus 10.2
43 cortical dysplasia, complex, with other brain malformations 7 10.2
44 polymicrogyria with or without vascular-type ehlers-danlos syndrome 10.2
45 sensorineural hearing loss 10.2
46 posterior uveitis 10.2
47 congenital toxoplasmosis 10.2
48 purpura 10.2
49 syphilis 10.2
50 eye disease 10.2

Graphical network of the top 20 diseases related to Zika Virus Infection:

Diseases related to Zika Virus Infection

Symptoms & Phenotypes for Zika Virus Infection

Drugs & Therapeutics for Zika Virus Infection

Drugs for Zika Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2
Aluminum sulfate Approved Phase 1 10043-01-3
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
5 Immunoglobulin G Phase 1
6 gamma-Globulins Phase 1
7 Immunoglobulins, Intravenous Phase 1
8 Antibodies, Blocking Phase 1
9 Rho(D) Immune Globulin Phase 1
10 Antibodies Phase 1
11 Immunoglobulins Phase 1
12 Antibodies, Monoclonal Phase 1
13 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 VRC 705: A Phase 2/2B, Randomized Trial to Evaluate the Safety, Immunogenicity and Efficacy of a Zika Virus DNA Vaccine in Healthy Adults and Adolescents Active, not recruiting NCT03110770 Phase 2
2 A Phase 1, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Immunogenicity of mRNA 1325 Zika Vaccine in Healthy Adults in a Non-endemic Zika Region Completed NCT03014089 Phase 1
3 A Phase 1, Randomized, Double-Blind Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of an Accelerated Vaccination Schedule With a Zika Virus Purified Inactivated Vaccine Plus Alum Adjuvant in Healthy Adults Completed NCT02937233 Phase 1
4 Safety and Pharmacokinetic Evaluation of Zika Virus Immune Globulin in Healthy Volunteers Completed NCT03624946 Phase 1
5 Double Blinded, Randomized, Placebo Controlled, Dose Finding Trial to Evaluate the Optimal Dose of MV-ZIKA, a New Vaccine Against Zika Virus, in Regard to Immunogenicity, Safety, and Tolerability in Healthy Volunteers Completed NCT02996890 Phase 1
6 A Randomized, Placebo-controlled, Observer-blinded Phase 1 Study to Assess the Safety and Immunogenicity of Two Different Dose Levels of an Alum Adjuvanted Inactivated Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Flavivirus-naïve Adults Aged 18 to 49 Years Completed NCT03425149 Phase 1
7 Phase I, Placebo-Controlled, Double-Blind Study To Evaluate The Safety, Tolerability, AND Immunogenicity Of GLS-5700, Administered ID Followed By Electroporation In Dengue Virus-Seropositive Adults Completed NCT02887482 Phase 1
8 Phase I, Open-label, Dose-Ranging Study to Evaluate the Safety, Tolerability, and Immunogenicity of GLS-5700 Administered ID Followed by EP in Dengue Virus-Naïve Adults Completed NCT02809443 Phase 1
9 Phase 1, Double-blinded, Placebo-Controlled Study of the Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) Administered by the Intramuscular Route in Flavivirus Naïve Adult Subjects Completed NCT02952833 Phase 1 Saline
10 Phase 1 First in Human, Time Lagged, Parallel-Group, Single Ascending Dose Study of Tyzivumab in Healthy Adult Volunteers Completed NCT03443830 Phase 1 Tyzivumab
11 VRC 319: A Phase I/Ib, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of A Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Completed NCT02840487 Phase 1
12 A Phase 1, First-in-Human, Double-blinded, Randomized, Placebo-controlled Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of an Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Healthy Flavivirus-Naïve and Flavivirus-Primed Subjects Completed NCT02963909 Phase 1
13 Observer Blinded, Randomized Trial to Evaluate Safety and Immunogenicity of a Novel Vaccine Formulation MV-ZIKA-RSP Recruiting NCT04033068 Phase 1
14 A Phase 1, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Healthy Flavivirus Seropositive and Seronegative Adults Recruiting NCT04064905 Phase 1
15 Phase 1 Time Lagged, Parallel-Group, Randomized, Placebo-Controlled, Single-Blind, Single Ascending Dose Study of Tyzivumab in ZIKV Infected Patients Recruiting NCT03776695 Phase 1
16 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate the Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) Administered by the Intramuscular Route in Adult Subjects Who Reside in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
17 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, in Healthy Adults Active, not recruiting NCT02996461 Phase 1
18 Phase I Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Active, not recruiting NCT03611946 Phase 1
19 A Phase 1, Randomized, Observer-Blind, Placebo-Controlled, Safety, Immunogenicity, and Dose Ranging Study of Purified Inactivated Zika Virus Vaccine (PIZV) Candidate in Flavivirus Naïve and Primed Healthy Adults Aged 18 to 49 Years Active, not recruiting NCT03343626 Phase 1 Placebo
20 Études Observationnelles Des conséquences néonatales et pédiatriques de l'Infection à Virus Zika au Cours de la Grossesse Pendant l'épidémie Des départements français d'Amérique de l'année 2016 Unknown status NCT02810210
21 Études Observationnelles Des conséquences de l'Infection à Virus Zika au Cours de la Grossesse Pendant l'épidémie Des départements français d'Amérique de l'année 2016 Unknown status NCT02916732
22 Effect of a Posture Adapter Use on Body Alignment in Standing Position on Children Between 12 and 24 Months Old With Zyka Virys Congenital Syndrome Unknown status NCT03227601
23 Prospective Surveillance and Case Definition Study of Zika Virus Disease and Infection in Adolescents and Adults in Latin America in Preparation for an Efficacy Trial of a Zika Virus Whole Virion, Purified Inactivated Vaccine Completed NCT03158233
24 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico (Zik01) Completed NCT02831699
25 Evaluation of the Clinical Performance of the ZIKV Detect™ 2.0 IgM Capture ELISA Completed NCT03776903
26 Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection During the First or Second Trimester of Gestation. Completed NCT03679728
27 Rash Accompanied by Three or More Dengue-like Symptoms During Pregnancy and Microcephaly: Case-control Study Completed NCT02741882
28 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
29 Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600
30 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456
31 Study of Zika Virus and Related Arbovirus Infections in Deferred Blood Donors Completed NCT02794181
32 Risk Evaluation of Fetal Nervous System and Neurodevelopment Disorders in Infants of Women Exposed to Zika Virus Infection During Pregnancy Recruiting NCT02943304
33 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444
34 Pregnant Women (PW) Cohort for Evaluation of Risks of Congenital Malformations and Other Adverse Pregnancy Outcomes After Zika Virus Infection (Part of ZIKAlliance) Recruiting NCT03188731
35 Descriptive and Prognostic Study of Arbovirus Infections in France, Based on a Hospital Cohort of Children and Adults With Suspected Arbovirose.r Recruiting NCT01099852
36 World Mosquito Program - Colombia (WMP-COLOMBIA): The Impact of City-wide Deployment of Wolbachia-infected Mosquitoes on Arboviral Disease Incidence in Medellin and Bello, Colombia Recruiting NCT03631719
37 Children (CH) Cohort for the Evaluation of Developmental and Neurological Abnormalities in Infants Born to Mothers Residing in Areas With Zika Virus Transmission During Pregnancy Recruiting NCT03393286
38 Applying Wolbachia to Eliminate Dengue (AWED): A Non-blinded Cluster Randomised Controlled Trial to Assess the Efficacy of Wolbachia-infected Mosquito Deployments to Reduce Dengue Incidence in Yogyakarta, Indonesia Recruiting NCT03055585
39 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment: Cohort Study in Fiocruz/IFF Recruiting NCT03255369
40 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Recruiting NCT03206541
41 International Prospective Observational Cohort Study of Zika in Infants Active, not recruiting NCT02856984
42 Persistence of Zika Virus in Semen After Acute Infection Active, not recruiting NCT02733796
43 Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Active, not recruiting NCT03263195
44 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Active, not recruiting NCT03106714
45 Screening For Critical Congenital Anomalies In NICU And Their Out Come in Assiut Universty Not yet recruiting NCT03882385
46 Longitudinal Clinical and Virological Study Among Symptomatic Patients With Zika Virus Infection in the City of Sao Paulo, Brazil Suspended NCT03204409
47 Survey of Symptoms and Dermatologic Characterization Associated With Zika Virus Withdrawn NCT03229421

Search NIH Clinical Center for Zika Virus Infection

Genetic Tests for Zika Virus Infection

Anatomical Context for Zika Virus Infection

MalaCards organs/tissues related to Zika Virus Infection:

Brain, Eye, Testes, T Cells, Fetal Brain, Placenta, Whole Blood

Publications for Zika Virus Infection

Articles related to Zika Virus Infection:

(show top 50) (show all 1321)
# Title Authors PMID Year
Guillain-Barre syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil. 38
31220435 2019
Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. 38
31097261 2019
Epidemiological and clinical suspicion of congenital Zika virus infection: Serological findings in mothers and children from Brazil. 38
31090222 2019
Receptive language skills among young children in rural Guatemala: The relationship between the Test de Vocabulario en Imagenes Peabody and a translated and adapted version of the Mullen Scales of Early Learning. 38
31270836 2019
Prevalence and Incidence of Zika Virus Infection Among Household Contacts of Patients With Zika Virus Disease, Puerto Rico, 2016-2017. 38
30544195 2019
A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection. 38
31142663 2019
Knowledge and attitude towards pregnancy-related issues of Zika virus infection among general practitioners in Indonesia. 38
31387537 2019
Urinary bladder agenesis and renal hypoplasia potentially related to in utero Zika virus infection. 38
31129423 2019
Protective to a T: The Role of T Cells during Zika Virus Infection. 38
31382545 2019
Updated baseline prevalence of birth defects potentially related to Zika virus infection. 38
31264801 2019
Zika virus infection and risk of Guillain-Barré syndrome: A meta-analysis. 38
31255970 2019
Serological evidence of Zika virus infection in non-human primates in Zambia. 38
31154511 2019
Epidemiology of Dengue, Chikungunya, and Zika Virus Disease in the U.S. States and Territories, 2017. 38
31436154 2019
Clinical relevance of Zika symptoms in the context of a Zika Dengue epidemic. 38
31399372 2019
Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic. 38
31407817 2019
Zika Virus Infection during Pregnancy and Sensorineural Hearing Loss among Children at 3 and 24 Months Post-Partum. 38
30252119 2019
Zika virus infection induces DNA damage response in human neural progenitors that enhances viral replication. 38
31375586 2019
Zika Virus Infection in Pregnant Women, Yucatan, Mexico. 38
31310215 2019
The Immunomodulatory Potential of the Metabolite Itaconate. 38
31178405 2019
The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3). 38
31375559 2019
Surveillance for Emerging Threats to Pregnant Women and Infants. 38
31408424 2019
Human Polyclonal Antibodies Prevent Lethal Zika Virus Infection in Mice. 38
31285451 2019
The effect of Zika virus infection in the ferret. 38
30680733 2019
Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches. 38
31370224 2019
High-throughput screening identifies mixed lineage kinase 3 as a key host regulatory factor in Zika virus infection. 38
31270223 2019
Correlation between cephalic circumference at birth and ocular alterations in patients with microcephaly potentially associated with Zika Virus infection. 38
31340324 2019
Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases. 38
30377986 2019
A chip-based potentiometric sensor for a Zika virus diagnostic using 3D surface molecular imprinting. 38
31180088 2019
Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-2016. 38
29963988 2019
Guillain-Barré syndrome associated with Zika virus infection in Honduras, 2016-2017. 38
31096053 2019
An update on the aspects of Zika virus infection on male reproductive system. 38
31147867 2019
Zika virus infection three years after the microcephaly outbreak: A meeting report. 38
31340378 2019
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System. 38
31283901 2019
Outcomes of Congenital Zika Virus Infection During an Outbreak in Valle del Cauca, Colombia. 38
30985517 2019
Phloretin inhibits Zika virus infection by interfering with cellular glucose utilisation. 38
30930299 2019
An investigation into the immune response of cultured neural rat cells following Zika virus infection. 38
30959341 2019
Zika virus disease in Spain. Surveillance results and epidemiology on reported cases, 2015-2017. 38
30797578 2019
Phytochemical composition and larvicidal activity of essential oils from herbal plants. 38
30904944 2019
Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils. 38
30971475 2019
Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein. 38
31043537 2019
Whole-Blood Testing for Diagnosis of Acute Zika Virus Infections in Routine Diagnostic Setting. 38
31008703 2019
Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana. 38
31182146 2019
Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice. 38
30264295 2019
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. 38
30858571 2019
Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection. 38
31107211 2019
Central and peripheral nervous system involvement in Zika virus infection in a child. 38
31222674 2019
Use of mosquito repellents to protect against Zika virus infection among pregnant women in Brazil. 38
31112836 2019
Postmortem evidence of disseminated Zika virus infection in an adult patient. 38
30763620 2019
Depressive Symptoms and Care Demands Among Primary Caregivers of Young Children with Evidence of Congenital Zika Virus Infection in Brazil. 38
30921104 2019
Auditory findings associated with Zika virus infection: an integrative review. 38
31296482 2019

Variations for Zika Virus Infection

Expression for Zika Virus Infection

Search GEO for disease gene expression data for Zika Virus Infection.

Pathways for Zika Virus Infection

Pathways related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.18 TP53 MDM2 AXL
2 11.82 TP53 MDM2
3 11.8 TP53 MDM2
4 11.73 TP53 MDM2
5 11.67 TP53 MDM2
6 11.65 TP53 MDM2
7 11.63 TP53 MDM2
8 11.6 TP53 MDM2
9 11.51 TP53 MDM2
Show member pathways
11.5 TP53 MDM2
11 11.46 TP53 MDM2
Show member pathways
11.4 TP53 MDM2
13 11.39 TP53 MDM2
14 11.37 TP53 MDM2
15 11.27 TP53 MDM2
Show member pathways
11.21 TP53 MDM2
17 11.19 TP53 MDM2
18 11.17 TP53 MDM2
19 11.03 TP53 MDM2
20 10.97 TP53 MDM2
21 10.76 TP53 MDM2
22 10.65 TP53 MDM2
Show member pathways
10.3 TP53 MDM2
24 9.97 TP53 MDM2

GO Terms for Zika Virus Infection

Biological processes related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.63 TP53 MDM2 AXL
2 cellular response to hypoxia GO:0071456 9.51 TP53 MDM2
3 protein-containing complex assembly GO:0065003 9.49 TP53 MDM2
4 regulation of signal transduction by p53 class mediator GO:1901796 9.48 TP53 MDM2
5 cellular response to hydrogen peroxide GO:0070301 9.43 MDM2 AXL
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.4 TP53 MDM2
7 blood vessel remodeling GO:0001974 9.37 MDM2 AXL
8 response to antibiotic GO:0046677 9.32 TP53 MDM2
9 cellular response to gamma radiation GO:0071480 9.26 TP53 MDM2
10 viral process GO:0016032 9.26 TP53 RSAD2 MDM2 AXL
11 positive regulation of protein export from nucleus GO:0046827 9.16 TP53 MDM2
12 cellular response to actinomycin D GO:0072717 8.62 TP53 MDM2

Molecular functions related to Zika Virus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.26 TP53 MDM2
2 p53 binding GO:0002039 9.16 TP53 MDM2
3 protein self-association GO:0043621 8.96 TP53 RSAD2
4 disordered domain specific binding GO:0097718 8.62 TP53 MDM2

Sources for Zika Virus Infection

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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