MCID: ZKV001
MIFTS: 41

Zika Virus Infection

Categories: Rare diseases

Aliases & Classifications for Zika Virus Infection

MalaCards integrated aliases for Zika Virus Infection:

Name: Zika Virus Infection 53 3 73
Zika Virus Disease 53
Zika Fever 53

Classifications:



External Ids:

UMLS 73 C0276289

Summaries for Zika Virus Infection

NIH Rare Diseases : 53 Zika virus infection is spread to people primarily through the bite of an infected mosquito. Zika virus can also be spread from a pregnant mother to her child and through sexual contact with an affected partner. Cases of Zika virus transmission via blood transfusion have also been reported. Zika virus outbreaks are currently occurring in many countries. The illness associated with Zika virus infection is usually mild, with symptoms lasting for several days to a week. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). However, research has suggested an association between Zika virus infection and Guillain-Barre syndrome (GBS) in a small percentage of cases. Zika virus infection during pregnancy can cause adverse pregnancy outcomes, including microcephaly and other serious brain defects. The full range of health problems associated with Zika virus infection during pregnancy is currently being studied. No vaccine currently exists to prevent Zika virus infection, but there are still ways to protect oneself. The CDC recommends that pregnant women consider postponing travel to Zika-affected areas. People living in or traveling to areas where Zika virus is found should take steps to prevent mosquito bites. Those who have traveled to Zika-affected areas may wish to take steps to prevent sexual transmission of the Zika virus.

MalaCards based summary : Zika Virus Infection, also known as zika virus disease, is related to zika fever and congenital zika syndrome. An important gene associated with Zika Virus Infection is AXL (AXL Receptor Tyrosine Kinase), and among its related pathways/superpathways are Akt Signaling and Glioma. The drugs Vaccines and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and t cells, and related phenotype is liver/biliary system.

CDC : 3 Get Email Updates

Related Diseases for Zika Virus Infection

Diseases related to Zika Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 zika fever 11.9
2 congenital zika syndrome 11.4
3 zika virus congenital syndrome 11.1
4 microcephaly 10.5
5 encephalitis 10.2
6 congenital toxoplasmosis 10.1
7 toxoplasmosis 10.1
8 neuropathy 10.0
9 dengue virus 10.0
10 type i 10.0
11 chikungunya 10.0
12 acute disseminated encephalomyelitis 10.0
13 ring chromosome 7 9.9 MDM2 TP53
14 actinic cheilitis 9.8 MDM2 TP53
15 sclerosing liposarcoma 9.8 MDM2 TP53
16 lip cancer 9.8 MDM2 TP53
17 periosteal osteogenic sarcoma 9.8 MDM2 TP53
18 dedifferentiated liposarcoma 9.8 MDM2 TP53
19 gliomatosis cerebri 9.8 MDM2 TP53
20 soft tissue sarcoma 9.8 MDM2 TP53
21 small cell sarcoma 9.8 MDM2 TP53
22 myxosarcoma 9.8 MDM2 TP53
23 glaucoma 3, primary congenital, a 9.8
24 posterior uveitis 9.8
25 influenza 9.8
26 corpus callosum, agenesis of, with abnormal genitalia 9.8
27 miller fisher syndrome 9.8
28 anxiety 9.8
29 uveitis 9.8
30 psoriasis 9.8
31 west nile virus 9.8
32 psoriasis 14, pustular 9.8
33 polyneuropathy 9.8
34 neonatal abstinence syndrome 9.8
35 epilepsy 9.8
36 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
37 optic nerve disease 9.8
38 hydrops fetalis, nonimmune, and/or atrial septal defect 9.8
39 cholecystitis 9.8
40 chronic inflammatory demyelinating polyneuropathy 9.8
41 orchitis 9.8
42 fetal edema 9.8
43 spinal cord injury 9.8
44 acalculous cholecystitis 9.8
45 hydrops fetalis 9.8
46 myelitis 9.8
47 pustular psoriasis 9.8
48 tick-borne encephalitis 9.8
49 purpura 9.8
50 depression 9.8

Graphical network of the top 20 diseases related to Zika Virus Infection:



Diseases related to Zika Virus Infection

Symptoms & Phenotypes for Zika Virus Infection

MGI Mouse Phenotypes related to Zika Virus Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 AXL MDM2 TP53

Drugs & Therapeutics for Zika Virus Infection

Drugs for Zika Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
3 Hypolipidemic Agents Phase 2
4 Anticholesteremic Agents Phase 2
5 Lipid Regulating Agents Phase 2
6 Anti-Inflammatory Agents Phase 2
7 Antimetabolites Phase 2
8
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
9
Aluminum sulfate Approved Phase 1 10043-01-3
10 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Recruiting NCT03110770 Phase 2
3 Yellow Fever Vaccine on Statin/ Non Statin Subjects Recruiting NCT03116802 Phase 2 Stamaril (live attenuated yellow fever vaccine)
4 Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Active, not recruiting NCT03014089 Phase 1, Phase 2
5 Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Completed NCT02996890 Phase 1
6 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
7 Safety, Immunogenicity and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Adult Participants Recruiting NCT03343626 Phase 1 Placebo
8 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers Recruiting NCT03356561 Phase 1
9 Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study Active, not recruiting NCT02937233 Phase 1
10 ZIKA Vaccine in Naive Subjects Active, not recruiting NCT02952833 Phase 1 Saline
11 A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. Active, not recruiting NCT02963909 Phase 1
12 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Active, not recruiting NCT02840487 Phase 1
13 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults Active, not recruiting NCT02996461 Phase 1
14 Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Active, not recruiting NCT03425149 Phase 1
15 Study of GLS-5700 in Dengue Virus Seropositive Adults Active, not recruiting NCT02887482 Phase 1
16 Study of GLS-5700 in Healthy Volunteers Active, not recruiting NCT02809443 Phase 1
17 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Active, not recruiting NCT03055000 Phase 1
18 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans Enrolling by invitation NCT03443830 Phase 1 Tyzivumab
19 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
20 Zika Case Definition and Surveillance Study Completed NCT03158233
21 Zika and Microcephaly: Case-control Study Completed NCT02741882
22 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456 Not Applicable
23 Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers Completed NCT02957344
24 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Recruiting NCT02810210
25 Zika Virus Infection's Pregnancy Consequences in French Department of America Recruiting NCT02916732
26 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
27 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
28 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
29 Zika in Infants and Pregnancy (ZIP) Recruiting NCT02856984
30 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Recruiting NCT02831699
31 Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Recruiting NCT03263195
32 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
33 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
34 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
35 ZIKAlliance Children Cohort (ZIKAllianceCH) Recruiting NCT03393286
36 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
37 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
38 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
39 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
40 Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome Recruiting NCT03227601 Not Applicable
41 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
42 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
43 Identification of Host Factors of Norovirus Infections in Mini-Gut Model Recruiting NCT03342547 Not Applicable
44 Screening for LID Clinical Studies Unit Healthy Volunteer Protocols Recruiting NCT01386424
45 Persistence of Zika Virus in Semen After Acute Infection Active, not recruiting NCT02733796
46 Dermatologic Manifestations of Zika Virus Enrolling by invitation NCT03229421
47 Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome Enrolling by invitation NCT03330600 Not Applicable
48 Spatial Repellents for Arbovirus Control Enrolling by invitation NCT03553277 Not Applicable
49 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
50 World Mosquito Program Noumea - Human Sample Component Not yet recruiting NCT03552094

Search NIH Clinical Center for Zika Virus Infection

Genetic Tests for Zika Virus Infection

Anatomical Context for Zika Virus Infection

MalaCards organs/tissues related to Zika Virus Infection:

41
Brain, Eye, T Cells, Fetal Brain, B Cells, Liver, Spinal Cord

Publications for Zika Virus Infection

Articles related to Zika Virus Infection:

(show top 50) (show all 155)
# Title Authors Year
1
Zika Virus Infection, Pregnancy and Microcephaly. ( 29341036 )
2018
2
The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. ( 29428508 )
2018
3
Designing B- and T-cell multi-epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection. ( 29900580 )
2018
4
Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain. ( 29934091 )
2018
5
In Reply-Cardiac Compromise in Zika Virus Infection. ( 29395352 )
2018
6
Electrocardiographic Finding in Zika Virus Infection. ( 29907402 )
2018
7
Zika virus infection in Nicaraguan households. ( 29851968 )
2018
8
Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study. ( 29894797 )
2018
9
Congenital syndrome associated with Zika virus infection among live births in Brazil: a description of the distribution of reported and confirmed cases in 2015-2016. ( 29972474 )
2018
10
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome. ( 29732381 )
2018
11
Autoimmune neuroretinopathy and Zika virus infection. ( 29909123 )
2018
12
Zika virus infection elicits auto-antibodies to C1q. ( 29382894 )
2018
13
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )
2018
14
Does immunity after Zika virus infection cross-protect against dengue? ( 29389533 )
2018
15
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. ( 29447264 )
2018
16
Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. ( 29846381 )
2018
17
What we know and what we don't know about perinatal Zika virus infection: a systematic review. ( 29415586 )
2018
18
Incidence of Guillain-BarrAc syndrome among Zika virus infected cases: a report from Thailand. ( 29364400 )
2018
19
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. ( 29400709 )
2018
20
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection. ( 29899743 )
2018
21
Author Response: Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections: Emphasis on the Role of Neuroimaging in Screening, Prognostication, and Follow-Up. ( 29037966 )
2018
22
Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda, 2014-2017. ( 29975185 )
2018
23
<i>PARP12</i> suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. ( 29921658 )
2018
24
Inhibition of Neurogenesis by Zika virus Infection. ( 29422006 )
2018
25
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells. ( 29395533 )
2018
26
Cardiac Compromise in Zika Virus Infection. ( 29397953 )
2018
27
Ophthalmologic Manifestations Associated With Zika Virus Infection. ( 29437049 )
2018
28
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients. ( 29912006 )
2018
29
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
30
Zika virus infection estimates, Mexico. ( 29875515 )
2018
31
Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections. ( 29037967 )
2018
32
Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States. ( 29372233 )
2018
33
In Reply-Electrocardiographic Finding in Zika Virus Infection. ( 29907401 )
2018
34
Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. ( 29844290 )
2018
35
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. ( 29967348 )
2018
36
Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. ( 29437050 )
2018
37
Generalized pustular psoriasis triggered by Zika virus infection. ( 29027743 )
2018
38
Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis. ( 29443111 )
2018
39
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. ( 29880824 )
2018
40
Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child. ( 29972576 )
2018
41
Auditory brainstem function in microcephaly related to Zika virus infection. ( 29352094 )
2018
42
Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. ( 29381706 )
2018
43
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection<i>In</i><i>Vitro</i>and in a Mouse Model. ( 29435494 )
2018
44
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. ( 29379210 )
2018
45
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs. ( 29405107 )
2018
46
Reply to: Zika Virus Infection, Pregnancy and Microcephaly. ( 29341037 )
2018
47
Prevalence of asymptomatic Zika virus infection: a systematic review. ( 29904223 )
2018
48
Zika Virus Infection in Children. ( 29406975 )
2018
49
Acute and chronic neurological consequences of early-life Zika virus infection in mice. ( 29875203 )
2018
50
Zika virus infection in a pediatric patient with acute gastrointestinal involvement. ( 29383222 )
2017

Variations for Zika Virus Infection

Expression for Zika Virus Infection

Search GEO for disease gene expression data for Zika Virus Infection.

Pathways for Zika Virus Infection

Pathways related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 AXL MDM2 TP53
2
Show member pathways
12.17 AXL MDM2 TP53
3 12.02 MDM2 TP53
4 11.96 MDM2 TP53
5 11.95 MDM2 TP53
6 11.95 MDM2 TP53
7
Show member pathways
11.91 MDM2 TP53
8 11.9 MDM2 TP53
9 11.83 MDM2 TP53
10 11.81 MDM2 TP53
11 11.8 MDM2 TP53
12 11.73 MDM2 TP53
13 11.71 MDM2 TP53
14
Show member pathways
11.71 MDM2 TP53
15 11.66 MDM2 TP53
16 11.65 MDM2 TP53
17 11.63 MDM2 TP53
18 11.6 MDM2 TP53
19 11.51 MDM2 TP53
20
Show member pathways
11.5 MDM2 TP53
21 11.46 MDM2 TP53
22 11.4 MDM2 TP53
23 11.39 MDM2 TP53
24
Show member pathways
11.37 MDM2 TP53
25 11.27 MDM2 TP53
26 11.21 MDM2 TP53
27 11.19 MDM2 TP53
28
Show member pathways
11.17 MDM2 TP53
29 11.07 MDM2 TP53
30 11.01 MDM2 TP53
31 10.76 MDM2 TP53
32 10.65 MDM2 TP53
33 10.3 MDM2 TP53
34
Show member pathways
9.97 MDM2 TP53

GO Terms for Zika Virus Infection

Biological processes related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 AXL MDM2 TP53
2 viral process GO:0016032 9.54 AXL MDM2 TP53
3 regulation of signal transduction by p53 class mediator GO:1901796 9.52 MDM2 TP53
4 protein-containing complex assembly GO:0065003 9.51 MDM2 TP53
5 cellular response to hypoxia GO:0071456 9.49 MDM2 TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.48 MDM2 TP53
7 cellular response to hydrogen peroxide GO:0070301 9.46 AXL MDM2
8 protein kinase B signaling GO:0043491 9.4 AXL MDM2
9 response to antibiotic GO:0046677 9.32 MDM2 TP53
10 blood vessel remodeling GO:0001974 9.26 AXL MDM2
11 cellular response to gamma radiation GO:0071480 9.16 MDM2 TP53
12 positive regulation of protein export from nucleus GO:0046827 8.96 MDM2 TP53
13 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Zika Virus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.16 MDM2 TP53
2 p53 binding GO:0002039 8.96 MDM2 TP53
3 disordered domain specific binding GO:0097718 8.62 MDM2 TP53

Sources for Zika Virus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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