MCID: ZKV001
MIFTS: 42

Zika Virus Infection

Categories: Rare diseases

Aliases & Classifications for Zika Virus Infection

MalaCards integrated aliases for Zika Virus Infection:

Name: Zika Virus Infection 53 3 73
Zika Virus Disease 53
Zika Fever 53

Classifications:



External Ids:

UMLS 73 C0276289

Summaries for Zika Virus Infection

NIH Rare Diseases : 53 Zika virus infection is spread to people primarily through the bite of an infected mosquito. Zika virus can also be spread from a pregnant mother to her child and through sexual contact with an affected partner. Cases of Zika virus transmission via blood transfusion have also been reported. Zika virus outbreaks are currently occurring in many countries. The illness associated with Zika virus infection is usually mild, with symptoms lasting for several days to a week. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). However, research has suggested an association between Zika virus infection and Guillain-Barre syndrome (GBS) in a small percentage of cases. Zika virus infection during pregnancy can cause adverse pregnancy outcomes, including microcephaly and other serious brain defects. The full range of health problems associated with Zika virus infection during pregnancy is currently being studied. No vaccine currently exists to prevent Zika virus infection, but there are still ways to protect oneself. The CDC recommends that pregnant women consider postponing travel to Zika-affected areas. People living in or traveling to areas where Zika virus is found should take steps to prevent mosquito bites. Those who have traveled to Zika-affected areas may wish to take steps to prevent sexual transmission of the Zika virus.

MalaCards based summary : Zika Virus Infection, also known as zika virus disease, is related to zika fever and congenital zika syndrome. An important gene associated with Zika Virus Infection is AXL (AXL Receptor Tyrosine Kinase), and among its related pathways/superpathways are Akt Signaling and Glioma. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotype is liver/biliary system.

CDC : 3 More

Related Diseases for Zika Virus Infection

Diseases related to Zika Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 zika fever 12.1
2 congenital zika syndrome 11.6
3 viral infectious disease 11.3
4 zika virus congenital syndrome 11.2
5 microcephaly 10.8
6 guillain-barre syndrome 10.6
7 dengue virus 10.5
8 chikungunya 10.4
9 encephalitis 10.3
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
11 anxiety 10.2
12 dengue disease 10.2
13 thrombocytopenia 10.2
14 congenital toxoplasmosis 10.2
15 neuropathy 10.2
16 toxoplasmosis 10.2
17 glaucoma 3, primary congenital, a 10.1
18 neuroblastoma 10.1
19 stroke, ischemic 10.1
20 dermatitis, atopic 10.1
21 spinal cord injury 10.1
22 uveitis 10.1
23 epilepsy 10.1
24 optic nerve disease 10.1
25 dermatitis 10.1
26 myelitis 10.1
27 purpura 10.1
28 acute disseminated encephalomyelitis 10.1
29 psoriasis 10.1
30 yellow fever 10.1
31 depression 10.1
32 seizure disorder 10.1
33 ring chromosome 7 10.0 MDM2 TP53
34 actinic cheilitis 10.0 MDM2 TP53
35 cheilitis 10.0 MDM2 TP53
36 sclerosing liposarcoma 9.9 MDM2 TP53
37 liposarcoma 9.9 MDM2 TP53
38 lip cancer 9.9 MDM2 TP53
39 periosteal osteogenic sarcoma 9.9 MDM2 TP53
40 gliomatosis cerebri 9.9 MDM2 TP53
41 soft tissue sarcoma 9.9 MDM2 TP53
42 dedifferentiated liposarcoma 9.9 MDM2 TP53
43 small cell sarcoma 9.9 MDM2 TP53
44 myxosarcoma 9.9 MDM2 TP53
45 verrucous carcinoma 9.9 MDM2 TP53
46 embryonal sarcoma 9.9 MDM2 TP53
47 cardia cancer 9.9 MDM2 TP53
48 adult medulloblastoma 9.9 MDM2 TP53
49 malignant mesenchymoma 9.9 MDM2 TP53
50 cellular schwannoma 9.9 MDM2 TP53

Graphical network of the top 20 diseases related to Zika Virus Infection:



Diseases related to Zika Virus Infection

Symptoms & Phenotypes for Zika Virus Infection

MGI Mouse Phenotypes related to Zika Virus Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 AXL MDM2 TP53

Drugs & Therapeutics for Zika Virus Infection

Drugs for Zika Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2,Phase 1
2 Vaccines Phase 2,Phase 1
3 Hypolipidemic Agents Phase 2
4 Anti-Inflammatory Agents Phase 2
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
6 Anticholesteremic Agents Phase 2
7 Lipid Regulating Agents Phase 2
8 Antimetabolites Phase 2
9
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
10
Aluminum sulfate Approved Phase 1 10043-01-3
11 Pharmaceutical Solutions Phase 1
12 Antibodies, Blocking Phase 1
13 Rho(D) Immune Globulin Phase 1
14 Antibodies Phase 1
15 gamma-Globulins Phase 1
16 Immunoglobulins Phase 1
17 Immunoglobulins, Intravenous Phase 1
18 Antibodies, Monoclonal Phase 1
19
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
20
Polyestradiol phosphate Approved 28014-46-2
21 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
22
Lactitol Investigational 585-86-4 3871
23 Estradiol 17 beta-cypionate
24 Estradiol 3-benzoate
25 Contraceptive Agents
26 Hormones, Hormone Substitutes, and Hormone Antagonists
27 Estrogens
28 Hormone Antagonists
29 Hormones

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 Yellow Fever Vaccine on Statin/ Non Statin Subjects Recruiting NCT03116802 Phase 2 Stamaril (live attenuated yellow fever vaccine)
3 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Active, not recruiting NCT03110770 Phase 2
4 Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Completed NCT02996890 Phase 1
5 Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study Completed NCT02937233 Phase 1
6 ZIKA Vaccine in Naive Subjects Completed NCT02952833 Phase 1 Saline
7 A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. Completed NCT02963909 Phase 1
8 Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Completed NCT03425149 Phase 1
9 Study of GLS-5700 in Dengue Virus Seropositive Adults Completed NCT02887482 Phase 1
10 Study of GLS-5700 in Healthy Volunteers Completed NCT02809443 Phase 1
11 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
12 Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG) Recruiting NCT03624946 Phase 1
13 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
14 Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Recruiting NCT03611946 Phase 1
15 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in ZIKV Infected Patients Recruiting NCT03776695 Phase 1
16 Safety, Immunogenicity and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Adult Participants Recruiting NCT03343626 Phase 1 Placebo
17 Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans Recruiting NCT03776786 Phase 1
18 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Active, not recruiting NCT02840487 Phase 1
19 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults Active, not recruiting NCT02996461 Phase 1
20 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans Active, not recruiting NCT03443830 Phase 1 Tyzivumab
21 Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Active, not recruiting NCT03014089 Phase 1
22 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers Active, not recruiting NCT03356561 Phase 1
23 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Unknown status NCT02810210
24 Zika Virus Infection's Pregnancy Consequences in French Department of America Unknown status NCT02916732
25 Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection Completed NCT03679728
26 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
27 Zika Case Definition and Surveillance Study Completed NCT03158233
28 Zika and Microcephaly: Case-control Study Completed NCT02741882
29 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456 Not Applicable
30 Evaluation of the Clinical Performance of the ZIKV Detect™ 2.0 IgM Capture ELISA Completed NCT03776903
31 Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers Completed NCT02957344
32 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
33 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
34 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
35 Zika in Infants and Pregnancy (ZIP) Recruiting NCT02856984
36 Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Recruiting NCT03263195
37 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
38 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
39 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
40 ZIKAlliance Children Cohort (ZIKAllianceCH) Recruiting NCT03393286
41 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
42 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
43 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
44 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
45 Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome Recruiting NCT03227601 Not Applicable
46 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
47 Wolbachia Disease Impact in Medellin and Bello Recruiting NCT03631719
48 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
49 Identification of Host Factors of Norovirus Infections in Mini-Gut Model Recruiting NCT03342547 Not Applicable
50 Screening for LID Clinical Studies Unit Healthy Volunteer Protocols Recruiting NCT01386424

Search NIH Clinical Center for Zika Virus Infection

Genetic Tests for Zika Virus Infection

Anatomical Context for Zika Virus Infection

MalaCards organs/tissues related to Zika Virus Infection:

41
Brain, Eye, Testes, T Cells, Skin, Kidney, Spinal Cord

Publications for Zika Virus Infection

Articles related to Zika Virus Infection:

(show top 50) (show all 743)
# Title Authors Year
1
Zika virus infection activates sting-dependent antiviral autophagy in the Drosophila brain. ( 30260713 )
2019
2
Cutaneous features of Zika virus infection: a clinicopathological overview. ( 30267436 )
2019
3
Epileptic spasms as the presenting seizure type in a patient with a new "O" of TORCH, congenital Zika virus infection. ( 30456170 )
2019
4
Zika Virus Infection, Pregnancy and Microcephaly. ( 29341036 )
2018
5
The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. ( 29428508 )
2018
6
Designing B- and T-cell multi-epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection. ( 29900580 )
2018
7
Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain. ( 29934091 )
2018
8
In Reply-Cardiac Compromise in Zika Virus Infection. ( 29395352 )
2018
9
Electrocardiographic Finding in Zika Virus Infection. ( 29907402 )
2018
10
Zika virus infection in Nicaraguan households. ( 29851968 )
2018
11
Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study. ( 29894797 )
2018
12
Congenital syndrome associated with Zika virus infection among live births in Brazil: a description of the distribution of reported and confirmed cases in 2015-2016. ( 29972474 )
2018
13
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome. ( 29732381 )
2018
14
Autoimmune neuroretinopathy and Zika virus infection. ( 29909123 )
2018
15
Zika virus infection elicits auto-antibodies to C1q. ( 29382894 )
2018
16
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )
2018
17
Does immunity after Zika virus infection cross-protect against dengue? ( 29389533 )
2018
18
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. ( 29447264 )
2018
19
Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. ( 29846381 )
2018
20
What we know and what we don't know about perinatal Zika virus infection: a systematic review. ( 29415586 )
2018
21
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. ( 29400709 )
2018
22
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection. ( 29899743 )
2018
23
Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda, 2014-2017. ( 29975185 )
2018
24
<i>PARP12</i> suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. ( 29921658 )
2018
25
Inhibition of Neurogenesis by Zika virus Infection. ( 29422006 )
2018
26
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells. ( 29395533 )
2018
27
Cardiac Compromise in Zika Virus Infection. ( 29397953 )
2018
28
Ophthalmologic Manifestations Associated With Zika Virus Infection. ( 29437049 )
2018
29
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients. ( 29912006 )
2018
30
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
31
Zika virus infection estimates, Mexico. ( 29875515 )
2018
32
Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States. ( 29372233 )
2018
33
In Reply-Electrocardiographic Finding in Zika Virus Infection. ( 29907401 )
2018
34
Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. ( 29844290 )
2018
35
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. ( 29967348 )
2018
36
Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. ( 29437050 )
2018
37
Generalized pustular psoriasis triggered by Zika virus infection. ( 29027743 )
2018
38
Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis. ( 29443111 )
2018
39
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. ( 29880824 )
2018
40
Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child. ( 29972576 )
2018
41
Auditory brainstem function in microcephaly related to Zika virus infection. ( 29352094 )
2018
42
Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. ( 29381706 )
2018
43
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection<i>In</i><i>Vitro</i>and in a Mouse Model. ( 29435494 )
2018
44
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. ( 29379210 )
2018
45
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs. ( 29405107 )
2018
46
Reply to: Zika Virus Infection, Pregnancy and Microcephaly. ( 29341037 )
2018
47
Prevalence of asymptomatic Zika virus infection: a systematic review. ( 29904223 )
2018
48
Case Report: Acute Transverse Myelitis after Zika Virus Infection. ( 30277201 )
2018
49
Experimental Zika virus infection in Aedes aegypti: Susceptibility, transmission & co-infection with dengue & chikungunya viruses. ( 29749366 )
2018
50
Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. ( 30439342 )
2018

Variations for Zika Virus Infection

Expression for Zika Virus Infection

Search GEO for disease gene expression data for Zika Virus Infection.

Pathways for Zika Virus Infection

Pathways related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 AXL MDM2 TP53
2
Show member pathways
12.17 AXL MDM2 TP53
3
Show member pathways
12.04 MDM2 TP53
4 12.02 MDM2 TP53
5 11.96 MDM2 TP53
6 11.96 MDM2 TP53
7 11.95 MDM2 TP53
8 11.91 MDM2 TP53
9
Show member pathways
11.91 MDM2 TP53
10 11.82 MDM2 TP53
11 11.8 MDM2 TP53
12 11.79 MDM2 TP53
13 11.73 MDM2 TP53
14 11.71 MDM2 TP53
15 11.66 MDM2 TP53
16 11.65 MDM2 TP53
17 11.63 MDM2 TP53
18 11.6 MDM2 TP53
19 11.51 MDM2 TP53
20
Show member pathways
11.5 MDM2 TP53
21 11.46 MDM2 TP53
22 11.4 MDM2 TP53
23 11.39 MDM2 TP53
24
Show member pathways
11.37 MDM2 TP53
25 11.36 MDM2 TP53
26 11.27 MDM2 TP53
27 11.21 MDM2 TP53
28 11.19 MDM2 TP53
29
Show member pathways
11.17 MDM2 TP53
30 11.07 MDM2 TP53
31 11.01 MDM2 TP53
32 10.76 MDM2 TP53
33 10.65 MDM2 TP53
34 10.3 MDM2 TP53
35
Show member pathways
9.97 MDM2 TP53

GO Terms for Zika Virus Infection

Biological processes related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.58 AXL MDM2 TP53
2 viral process GO:0016032 9.54 AXL MDM2 TP53
3 cellular response to hypoxia GO:0071456 9.51 MDM2 TP53
4 protein-containing complex assembly GO:0065003 9.49 MDM2 TP53
5 regulation of signal transduction by p53 class mediator GO:1901796 9.48 MDM2 TP53
6 cellular response to hydrogen peroxide GO:0070301 9.46 AXL MDM2
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 MDM2 TP53
8 blood vessel remodeling GO:0001974 9.32 AXL MDM2
9 response to antibiotic GO:0046677 9.26 MDM2 TP53
10 cellular response to gamma radiation GO:0071480 9.16 MDM2 TP53
11 positive regulation of protein export from nucleus GO:0046827 8.96 MDM2 TP53
12 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Zika Virus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.16 MDM2 TP53
2 p53 binding GO:0002039 8.96 MDM2 TP53
3 disordered domain specific binding GO:0097718 8.62 MDM2 TP53

Sources for Zika Virus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....