MCID: ZKV001
MIFTS: 42

Zika Virus Infection

Categories: Rare diseases

Aliases & Classifications for Zika Virus Infection

MalaCards integrated aliases for Zika Virus Infection:

Name: Zika Virus Infection 54 74 3
Zika Virus Disease 54
Zika Fever 54

Classifications:



External Ids:

UMLS 74 C0276289

Summaries for Zika Virus Infection

NIH Rare Diseases : 54 Zika virus infection is spread to people primarily through the bite of an infected mosquito. Zika virus can also be spread from a pregnant mother to her child and through sexual contact with an affected partner. Cases of Zika virus transmission via blood transfusion have also been reported. Zika virus outbreaks are currently occurring in many countries. The illness associated with Zika virus infection is usually mild, with symptoms lasting for several days to a week. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). However, research has suggested an association between Zika virus infection and Guillain-Barre syndrome (GBS) in a small percentage of cases. Zika virus infection during pregnancy can cause adverse pregnancy outcomes, including microcephaly and other serious brain defects. The full range of health problems associated with Zika virus infection during pregnancy is currently being studied. No vaccine currently exists to prevent Zika virus infection, but there are still ways to protect oneself. The CDC recommends that pregnant women consider postponing travel to Zika-affected areas. People living in or traveling to areas where Zika virus is found should take steps to prevent mosquito bites. Those who have traveled to Zika-affected areas may wish to take steps to prevent sexual transmission of the Zika virus.

MalaCards based summary : Zika Virus Infection, also known as zika virus disease, is related to zika fever and congenital zika syndrome. An important gene associated with Zika Virus Infection is AXL (AXL Receptor Tyrosine Kinase), and among its related pathways/superpathways are Glioma and Cellular senescence (KEGG). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

CDC : 3 What everyone needs to know about Zika virus.

Related Diseases for Zika Virus Infection

Diseases related to Zika Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 zika fever 12.1
2 congenital zika syndrome 11.6
3 zika virus congenital syndrome 11.3
4 microcephaly 10.8
5 guillain-barre syndrome 10.6
6 dengue virus 10.5
7 chikungunya 10.4
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
9 encephalitis 10.3
10 thrombocytopenia 10.2
11 cytokine deficiency 10.2
12 anxiety 10.2
13 dengue disease 10.2
14 congenital toxoplasmosis 10.2
15 neuropathy 10.2
16 toxoplasmosis 10.2
17 glaucoma 3, primary congenital, a 10.1
18 neuroblastoma 10.1
19 stroke, ischemic 10.1
20 dermatitis, atopic 10.1
21 spinal cord injury 10.1
22 uveitis 10.1
23 epilepsy 10.1
24 optic nerve disease 10.1
25 dermatitis 10.1
26 myelitis 10.1
27 purpura 10.1
28 acute disseminated encephalomyelitis 10.1
29 psoriasis 10.1
30 yellow fever 10.1
31 depression 10.1
32 seizure disorder 10.1
33 myasthenia gravis 9.9
34 corpus callosum, agenesis of, with abnormal genitalia 9.9
35 noonan syndrome 3 9.9
36 west nile virus 9.9
37 malaria 9.9
38 psoriasis 14, pustular 9.9
39 lymphatic malformation 7 9.9
40 cerebral palsy 9.9
41 chronic inflammatory demyelinating polyneuropathy 9.9
42 neuromyelitis optica 9.9
43 tick-borne encephalitis 9.9
44 exanthem 9.9
45 atrial fibrillation 9.9
46 sensorineural hearing loss 9.9
47 respiratory failure 9.9
48 nephrotic syndrome 9.9
49 panuveitis 9.9
50 posterior uveitis 9.9

Graphical network of the top 20 diseases related to Zika Virus Infection:



Diseases related to Zika Virus Infection

Symptoms & Phenotypes for Zika Virus Infection

Drugs & Therapeutics for Zika Virus Infection

Drugs for Zika Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Immunologic Factors Phase 2,Phase 1
3 Anticholesteremic Agents Phase 2
4 Lipid Regulating Agents Phase 2
5 Hypolipidemic Agents Phase 2
6 Anti-Inflammatory Agents Phase 2
7 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
8 Antimetabolites Phase 2
9
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
10
Aluminum sulfate Approved Phase 1 10043-01-3
11 Pharmaceutical Solutions Phase 1
12 Antibodies, Monoclonal Phase 1
13 Immunoglobulins Phase 1
14 Antibodies Phase 1
15 Rho(D) Immune Globulin Phase 1
16 Immunoglobulins, Intravenous Phase 1
17 Immunoglobulin G Phase 1
18 Antibodies, Blocking Phase 1
19 gamma-Globulins Phase 1
20
Polyestradiol phosphate Approved 28014-46-2
21
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
22
Lactitol Investigational 585-86-4, 585-88-6 493591
23 Hormones, Hormone Substitutes, and Hormone Antagonists
24 Contraceptive Agents
25 Estrogens
26 Hormone Antagonists
27 Estradiol 3-benzoate
28 Hormones
29 Estradiol 17 beta-cypionate

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 Yellow Fever Vaccine on Statin/ Non Statin Subjects Recruiting NCT03116802 Phase 2 Stamaril (live attenuated yellow fever vaccine)
3 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Active, not recruiting NCT03110770 Phase 2
4 Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability Completed NCT02996890 Phase 1
5 Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study Completed NCT02937233 Phase 1
6 ZIKA Vaccine in Naive Subjects Completed NCT02952833 Phase 1 Saline
7 A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. Completed NCT02963909 Phase 1
8 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Completed NCT02840487 Phase 1
9 Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults Completed NCT03425149 Phase 1
10 Study of GLS-5700 in Dengue Virus Seropositive Adults Completed NCT02887482 Phase 1
11 Study of GLS-5700 in Healthy Volunteers Completed NCT02809443 Phase 1
12 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
13 Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area Recruiting NCT03008122 Phase 1
14 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in ZIKV Infected Patients Recruiting NCT03776695 Phase 1
15 Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans Recruiting NCT03776786 Phase 1
16 Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG) Active, not recruiting NCT03624946 Phase 1
17 Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Active, not recruiting NCT03611946 Phase 1
18 VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults Active, not recruiting NCT02996461 Phase 1
19 Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans Active, not recruiting NCT03443830 Phase 1 Tyzivumab
20 Safety, Immunogenicity and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Adult Participants Active, not recruiting NCT03343626 Phase 1 Placebo
21 Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects Active, not recruiting NCT03014089 Phase 1
22 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers Active, not recruiting NCT03356561 Phase 1
23 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Unknown status NCT02810210
24 Zika Virus Infection's Pregnancy Consequences in French Department of America Unknown status NCT02916732
25 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Unknown status NCT03078894
26 Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection Completed NCT03679728
27 Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Completed NCT02979938
28 Zika Case Definition and Surveillance Study Completed NCT03158233
29 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Completed NCT02831699
30 Zika and Microcephaly: Case-control Study Completed NCT02741882
31 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Completed NCT02794181
32 Pilot Study to Detect Zika Virus in Sperm Completed NCT02874456 Not Applicable
33 Evaluation of the Clinical Performance of the ZIKV Detect™ 2.0 IgM Capture ELISA Completed NCT03776903
34 Spatial Repellents for Arbovirus Control Completed NCT03553277 Not Applicable
35 Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers Completed NCT02957344
36 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
37 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
38 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
39 Zika in Infants and Pregnancy (ZIP) Recruiting NCT02856984
40 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
41 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
42 ZIKAlliance Children Cohort (ZIKAllianceCH) Recruiting NCT03393286
43 Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia Recruiting NCT03631719
44 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
45 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
46 Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome Recruiting NCT03227601 Not Applicable
47 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
48 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
49 World Mosquito Program Noumea - Human Sample Component Recruiting NCT03552094
50 Identification of Host Factors of Norovirus Infections in Mini-Gut Model Recruiting NCT03342547 Not Applicable

Search NIH Clinical Center for Zika Virus Infection

Genetic Tests for Zika Virus Infection

Anatomical Context for Zika Virus Infection

MalaCards organs/tissues related to Zika Virus Infection:

42
Brain, Eye, Testes, T Cells, Fetal Brain, Placenta, Monocytes

Publications for Zika Virus Infection

Articles related to Zika Virus Infection:

(show top 50) (show all 805)
# Title Authors Year
1
Does prior dengue virus exposure worsen clinical outcomes of Zika virus infection? A systematic review, pooled analysis and lessons learned. ( 30682026 )
2019
2
Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments. ( 30890698 )
2019
3
Guillain-Barré syndrome associated with Zika virus infection in Brazil: a cost-of-illness study. ( 30892628 )
2019
4
Clinical, Neuroimaging, and Neurophysiological Findings in Children with Microcephaly Related to Congenital Zika Virus Infection. ( 30678125 )
2019
5
The association between Zika virus infection and microcephaly in Brazil 2015-2017: An observational analysis of over 4 million births. ( 30835728 )
2019
6
Neuromyelitis optica spectrum disorder associated with Zika virus infection. ( 30859012 )
2019
7
Incidence and Outcome of Severe and Nonsevere Thrombocytopenia Associated With Zika Virus Infection-Puerto Rico, 2016. ( 30631791 )
2019
8
Epileptic spasms as the presenting seizure type in a patient with a new "O" of TORCH, congenital Zika virus infection. ( 30456170 )
2019
9
Neurological Complications of Congenital Zika Virus Infection. ( 30591235 )
2019
10
Evaluation of Patients for Zika Virus Infection in a Travel Clinic in the Southeast United States, 2016. ( 30608632 )
2019
11
Commentary on "Evaluation of Patients for Zika Virus Infection in a Travel Clinic in the Southeast United States, 2016". ( 30608633 )
2019
12
A 'Furry-Tale' of Zika Virus Infection: What Have We Learned from Animal Models? ( 30621317 )
2019
13
Differential Zika Virus Infection of Testicular Cell Lines. ( 30634400 )
2019
14
Interferon lambda protects the female reproductive tract against Zika virus infection. ( 30655513 )
2019
15
Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool. ( 30657537 )
2019
16
Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon. ( 30657788 )
2019
17
Zika Virus Infection RIG-ged by Keratinocytes and Fibroblasts. ( 30665581 )
2019
18
Little Evidence of Zika Virus Infection in Wild Long-Tailed Macaques, Peninsular Malaysia. ( 30666941 )
2019
19
CD4+ T cells promote humoral immunity and viral control during Zika virus infection. ( 30677097 )
2019
20
Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters. ( 30678320 )
2019
21
The effect of Zika virus infection in the ferret. ( 30680733 )
2019
22
Clinical, Virologic, and Immunologic Characteristics of Zika Virus Infection in a Cohort of US Patients: Prolonged RNA Detection in Whole Blood. ( 30697574 )
2019
23
Glycosaminoglycan Compositional Analysis of Relevant Tissues in ZIKV Pathogenesis and in vitro Evaluation of Heparin as Antiviral Against ZIKV Infection. ( 30698412 )
2019
24
Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells. ( 30716104 )
2019
25
Zika virus infection in Tupaia belangeri causes dermatological manifestations and confers protection against secondary infection. ( 30728253 )
2019
26
Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise. ( 30728813 )
2019
27
Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. ( 30735502 )
2019
28
Evaluation of a new rapid fluorescence immunoassay for the diagnosis of dengue and Zika virus infection. ( 30738366 )
2019
29
A diagnostic gap illuminated by a sexually-transmitted case of congenital Zika virus infection. ( 30739645 )
2019
30
Zika virus infection in pregnant women in a General Hospital of Veracruz, Mexico. ( 30760071 )
2019
31
Zika virus infection in Malaysia: an epidemiological, clinical and virological analysis. ( 30760239 )
2019
32
Postmortem evidence of disseminated Zika virus infection in an adult patient. ( 30763620 )
2019
33
Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study. ( 30771526 )
2019
34
Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain. ( 30799482 )
2019
35
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. ( 30814679 )
2019
36
Hearing Loss From Congenital Zika Virus Infection. ( 30817676 )
2019
37
Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication. ( 30823365 )
2019
38
Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis. ( 30842564 )
2019
39
Zika Virus Infection, Basic and Clinical Aspects: A Review Article. ( 30847308 )
2019
40
Zika virus infection in travellers returning to the United Kingdom during the period of the outbreak in the Americas (2016-17): A retrospective analysis. ( 30853504 )
2019
41
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. ( 30858571 )
2019
42
Innate immune response in patients with acute Zika virus infection. ( 30879197 )
2019
43
Screening for Zika virus infection in 1057 potentially exposed pregnant women, Catalonia (northeastern Spain). ( 30885699 )
2019
44
Lack of Transmission of Zika Virus Infection to Breastfed Infant. ( 30886528 )
2019
45
ZIKV-specific NS1 epitopes as serological markers of acute Zika virus infection. ( 30901054 )
2019
46
Effects of dengue immunity on Zika virus infection. ( 30911157 )
2019
47
Zika virus infection activates sting-dependent antiviral autophagy in the Drosophila brain. ( 30260713 )
2019
48
Cutaneous features of Zika virus infection: a clinicopathological overview. ( 30267436 )
2019
49
Zika virus disease in Spain. Surveillance results and epidemiology on reported cases, 2015-2017. ( 30797578 )
2019
50
Postnatally acquired Zika virus disease among children, United States, 2016-2017. ( 30855072 )
2019

Variations for Zika Virus Infection

Expression for Zika Virus Infection

Search GEO for disease gene expression data for Zika Virus Infection.

Pathways for Zika Virus Infection

Pathways related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 AXL MDM2 TP53
2 11.82 MDM2 TP53
3 11.8 MDM2 TP53
4 11.73 MDM2 TP53
5 11.66 MDM2 TP53
6 11.65 MDM2 TP53
7 11.63 MDM2 TP53
8 11.6 MDM2 TP53
9 11.51 MDM2 TP53
10
Show member pathways
11.5 MDM2 TP53
11 11.46 MDM2 TP53
12 11.4 MDM2 TP53
13 11.39 MDM2 TP53
14
Show member pathways
11.37 MDM2 TP53
15 11.27 MDM2 TP53
16 11.21 MDM2 TP53
17 11.19 MDM2 TP53
18
Show member pathways
11.17 MDM2 TP53
19 11.03 MDM2 TP53
20 10.97 MDM2 TP53
21 10.76 MDM2 TP53
22 10.65 MDM2 TP53
23 10.3 MDM2 TP53
24
Show member pathways
9.97 MDM2 TP53

GO Terms for Zika Virus Infection

Biological processes related to Zika Virus Infection according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.63 AXL MDM2 TP53
2 cellular response to hypoxia GO:0071456 9.51 MDM2 TP53
3 protein-containing complex assembly GO:0065003 9.49 MDM2 TP53
4 regulation of signal transduction by p53 class mediator GO:1901796 9.48 MDM2 TP53
5 cellular response to hydrogen peroxide GO:0070301 9.43 AXL MDM2
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.4 MDM2 TP53
7 blood vessel remodeling GO:0001974 9.37 AXL MDM2
8 response to antibiotic GO:0046677 9.32 MDM2 TP53
9 cellular response to gamma radiation GO:0071480 9.26 MDM2 TP53
10 viral process GO:0016032 9.26 AXL MDM2 RSAD2 TP53
11 positive regulation of protein export from nucleus GO:0046827 9.16 MDM2 TP53
12 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Zika Virus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.26 MDM2 TP53
2 p53 binding GO:0002039 9.16 MDM2 TP53
3 protein self-association GO:0043621 8.96 RSAD2 TP53
4 disordered domain specific binding GO:0097718 8.62 MDM2 TP53

Sources for Zika Virus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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