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MCID: ZNC004
MIFTS: 23
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Zinc Deficiency, Transient Neonatal
Categories:
Genetic diseases
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MalaCards integrated aliases for Zinc Deficiency, Transient Neonatal:
Characteristics:OMIM:57
Inheritance:
autosomal dominant
Miscellaneous:
reduced zinc in affected mother's breast milk is unresponsive to oral zinc supplementation symptoms of zinc deficiency occur only in exclusively breastfed infants dermatitis resolves in offspring after zinc supplementation and/or weaning zinc deficiency in breastfed offspring resolves after weaning mother who carries the mutation is clinically unaffected HPO:32
zinc deficiency, transient neonatal:
Inheritance autosomal dominant inheritance autosomal recessive inheritance Classifications: |
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OMIM
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57
Transient neonatal zinc deficiency occurs in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Chowanadisai et al., 2006).
Some aspects of TNZD resemble the more severe disorder acrodermatitis enteropathica (AEZ; 201100), an autosomal recessive disorder caused by mutation in the zinc transporter SLC39A4 (607059). However, infants with transient neonatal zinc deficiency do not require zinc supplementation following weaning and have normal zinc absorption, whereas those with AEZ require lifelong zinc supplementation (summary by Chowanadisai et al., 2006). (608118)
MalaCards based summary : Zinc Deficiency, Transient Neonatal, also known as zinc deficiency, neonatal, due to low breast milk zinc, is related to enteropathica and acrodermatitis enteropathica, zinc-deficiency type. An important gene associated with Zinc Deficiency, Transient Neonatal is SLC30A2 (Solute Carrier Family 30 Member 2). Affiliated tissues include breast and skin, and related phenotypes are abnormality of the skin and eczema UniProtKB/Swiss-Prot : 75 Zinc deficiency, transient neonatal: A disorder occurring in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance. |
Diseases related to Zinc Deficiency, Transient Neonatal via text searches within MalaCards or GeneCards Suite gene sharing:
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:608118Human phenotypes related to Zinc Deficiency, Transient Neonatal:32
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MalaCards organs/tissues related to Zinc Deficiency, Transient Neonatal:41
Breast,
Skin
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Articles related to Zinc Deficiency, Transient Neonatal:
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Genes related to Zinc Deficiency, Transient Neonatal (1 elite genes):
- Elite gene
- Cancer Census gene in COSMIC
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UniProtKB/Swiss-Prot genetic disease variations for Zinc Deficiency, Transient Neonatal:75
ClinVar genetic disease variations for Zinc Deficiency, Transient Neonatal:6
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Search
GEO
for disease gene expression data for Zinc Deficiency, Transient Neonatal.
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