NAE
MCID: ZNC005
MIFTS: 17

Zinc-Responsive Necrolytic Acral Erythema (NAE)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Zinc-Responsive Necrolytic Acral Erythema

MalaCards integrated aliases for Zinc-Responsive Necrolytic Acral Erythema:

Name: Zinc-Responsive Necrolytic Acral Erythema 58
Necrolytic Acral Erythema 58
Nae 58

Characteristics:

Orphanet epidemiological data:

58
zinc-responsive necrolytic acral erythema
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 L53.8
Orphanet 58 ORPHA439196

Summaries for Zinc-Responsive Necrolytic Acral Erythema

MalaCards based summary : Zinc-Responsive Necrolytic Acral Erythema, also known as necrolytic acral erythema, is related to hepatitis c and hepatitis c virus. The drug Antiviral Agents has been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 74 Necrolytic acral erythema is a cutaneous condition that is a manifestation of hepatitis C viral... more...

Related Diseases for Zinc-Responsive Necrolytic Acral Erythema

Diseases related to Zinc-Responsive Necrolytic Acral Erythema via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 hepatitis c 10.8
2 hepatitis c virus 10.8
3 hepatitis 10.6
4 papilloma 10.5
5 acrodermatitis enteropathica, zinc-deficiency type 10.4
6 exanthem 10.4
7 keratosis 10.4
8 acrodermatitis 10.4
9 enteropathica 10.4
10 hepatitis b 10.4
11 cryoglobulinemia 10.4
12 pellagra 10.4
13 encephalopathy 10.3
14 ovarian cancer 10.3
15 pustulosis of palm and sole 10.3
16 psoriasis 10.3
17 ataxia and polyneuropathy, adult-onset 10.2
18 hashimoto encephalopathy 10.2
19 annular erythema 10.2
20 systemic lupus erythematosus 10.2
21 porphyria cutanea tarda 10.2
22 dowling-degos disease 1 10.2
23 immune deficiency disease 10.2
24 ocular motor apraxia 10.2
25 erythema multiforme 10.2
26 vitamin b12 deficiency 10.2
27 biotin deficiency 10.2
28 porphyria 10.2
29 urticaria 10.2
30 viral hepatitis 10.2
31 dermatitis 10.2
32 cellulitis 10.2
33 skin disease 10.2
34 lichen planus 10.2
35 polyarteritis nodosa 10.2
36 posttransplant acute limbic encephalitis 10.2
37 multiple system atrophy 1 10.1
38 myeloma, multiple 10.1
39 myxedema 10.1
40 myelodysplastic syndrome 10.1
41 cryptococcosis 10.1
42 hypothyroidism 10.1
43 severe combined immunodeficiency 10.1
44 acquired immunodeficiency syndrome 10.1
45 thyroiditis 10.1
46 herpes simplex 10.1
47 vasculitis 10.1
48 encephalitis 10.1
49 myoclonus 10.1
50 tremor 10.1

Graphical network of the top 20 diseases related to Zinc-Responsive Necrolytic Acral Erythema:



Diseases related to Zinc-Responsive Necrolytic Acral Erythema

Symptoms & Phenotypes for Zinc-Responsive Necrolytic Acral Erythema

Drugs & Therapeutics for Zinc-Responsive Necrolytic Acral Erythema

Drugs for Zinc-Responsive Necrolytic Acral Erythema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pattern of Skin Manifestations in Chronic Hepatitis c Virus Patients Before and After Direct Acting Anti Viral Drugs: Prospective Controlled Clinical Trial Unknown status NCT03170076

Search NIH Clinical Center for Zinc-Responsive Necrolytic Acral Erythema

Genetic Tests for Zinc-Responsive Necrolytic Acral Erythema

Anatomical Context for Zinc-Responsive Necrolytic Acral Erythema

MalaCards organs/tissues related to Zinc-Responsive Necrolytic Acral Erythema:

40
Skin

Publications for Zinc-Responsive Necrolytic Acral Erythema

Articles related to Zinc-Responsive Necrolytic Acral Erythema:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Zinc-responsive necrolytic acral erythema in ovarian cancer. 61
32350902 2020
2
Necrolytic Acral Erythema in Seronegative Hepatitis C Patient with Vitamin B12 Deficiency. 61
32478002 2020
3
Necrolytic Acral Erythema: Current Insights. 61
32308461 2020
4
Rivaroxaban induced necrolytic acral erythema. 61
31235525 2019
5
Symmetric acral annular erythema: a variant of erythema annulare centrifugum, necrolytic acral erythema or a distinct clinical entity? 61
31320861 2019
6
Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report. 61
30820272 2019
7
Necrolytic acral erythema in a Chinese patient with hepatitis C and hepatitis B virus coinfection. 61
31644618 2019
8
Necrolytic acral erythema leading to diagnosis of chronic hepatitis C. 61
29622385 2018
9
Image Gallery: Seronegative necrolytic acral erythema. 61
30141562 2018
10
Dermatologic Manifestations of Chronic Hepatitis C Infection. 61
28689593 2017
11
Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era. 61
28252812 2017
12
Acral manifestations of viral infections. 61
27938811 2017
13
Necrolytic Acral Erythema in Seronegative Hepatitis C. 61
28611625 2017
14
Necrolytic acral erythema: a rare skin disease associated with hepatitis C virus infection. 61
27828642 2016
15
Zinc-Responsive Necrolytic Acral Erythema in a Patient With Psoriasis: A Rare Case. 61
27272315 2016
16
Seronegative necrolytic acral erythema: A report of two cases and literature review. 61
27559510 2016
17
Necrolytic Acral Erythema in the Absence of Hepatitis C Virus Infection. 61
26955109 2016
18
Cutaneous manifestations of hepatitis C in the era of new antiviral agents. 61
26644817 2015
19
Zinc deficiency presenting with necrolytic acral erythema and coma. 61
25863150 2015
20
Necrolytic acral erythema following hepatitis B vaccination. 61
24787551 2014
21
Necrolytic acral erythema masquerading as cellulitis. 61
25419746 2014
22
Necrolytic acral erythema. 61
24365000 2013
23
Low prevalence of necrolytic acral erythema in patients with chronic hepatitis C virus infection. 61
22325461 2012
24
Necrolytic acral erythema. 61
23135092 2012
25
Morphologic features of extrahepatic manifestations of hepatitis C virus infection. 61
22919404 2012
26
Necrolytic acral erythema in an adolescent. 61
21967447 2011
27
The necrolytic erythemas: a continuous spectrum? 61
22106727 2011
28
Necrolytic acral erythema. 61
21488794 2011
29
Diagnosing necrolytic acral erythema: does anything go? 61
21716945 2011
30
Necrolytic acral erythema. 61
21163166 2010
31
Necrolytic acral erythema as a cutaneous marker of hepatitis C: report of two cases and review. 61
20499177 2010
32
Evaluation of zinc level in skin of patients with necrolytic acral erythema. 61
20426777 2010
33
Leukocytoclastic vasculitis and necrolytic acral erythema in patients with hepatitis C infection: do viral load and viral genotype play a role? 61
20462666 2010
34
Seronegative necrolytic acral erythema: a distinct clinical subset? 61
21063519 2010
35
Necrolytic acral erythema: an expanding spectrum. 61
20166571 2009
36
Necrolytic acral erythema seronegative for hepatitis C virus--two cases from India treated with oral zinc. 61
19775403 2009
37
Necrolytic acral erythema: a review of the literature. 61
19681342 2009
38
Lack of classic histology should not prevent diagnosis of necrolytic acral erythema. 61
18992966 2009
39
Necrolytic acral erythema without hepatitis C infection. 61
19220632 2009
40
Necrolytic acral erythema: successful treatment with topical tacrolimus ointment. 61
18986360 2008
41
Necrolytic acral erythema successfully treated with oral zinc. 61
18717879 2008
42
Hypozincemia and hyperzincuria associated with necrolytic acral erythema. 61
18613880 2008
43
Necrolytic acral erythema: a case not associated with hepatitis C infection. 61
18713591 2008
44
Necrolytic acral erythema: case report and review of the literature. 61
18491486 2008
45
Zinc deficiency associated with necrolytic acral erythema. 61
17052522 2006
46
Necrolytic acral erythema in Egyptian patients with hepatitis C virus infection. 61
16824076 2006
47
Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity? 61
16336523 2005
48
Necrolytic acral erythema: a cutaneous sign of hepatitis C virus infection. 61
16021118 2005
49
Necrolytic acral erythema: a patient from the United States successfully treated with oral zinc. 61
15655150 2005
50
The glucagonoma syndrome and necrolytic migratory erythema: a clinical review. 61
15538929 2004

Variations for Zinc-Responsive Necrolytic Acral Erythema

Expression for Zinc-Responsive Necrolytic Acral Erythema

Search GEO for disease gene expression data for Zinc-Responsive Necrolytic Acral Erythema.

Pathways for Zinc-Responsive Necrolytic Acral Erythema

GO Terms for Zinc-Responsive Necrolytic Acral Erythema

Sources for Zinc-Responsive Necrolytic Acral Erythema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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