Zygodactyly 1 (ZD1)

External Ids:

Disease Ontology 12 DOID:0111820 OMIM® 57 609815 ICD10 via Orphanet 33 Q70.3 UMLS via Orphanet 71 C1853294

Orphanet 58 ORPHA295187 MedGen 41 C1853294 UMLS 70 C1853294

OMIM® : ⁵⁷ Syndactyly type I (185900) is an autosomal dominant limb malformation characterized in its classical form by complete or partial webbing between the third and fourth fingers and/or the second and third toes. Zygodactyly is a subtype of type I syndactyly in which webbing of second and third toes occurs without hand involvement (summary by Malik et al., 2005). (609815) (Updated 05-Apr-2021)

MalaCards based summary : Zygodactyly 1, also known as syndactyly type 1, weidenreich type, is related to chromosome 2q35 duplication syndrome and craniosynostosis. An important gene associated with Zygodactyly 1 is ZD1 (Zygodactyly 1), and among its related pathways/superpathways are Phospholipase-C Pathway and ECM-receptor interaction. Related phenotype is craniofacial.

Disease Ontology : ¹² A syndactyly characterized by webbing between the second and third toes in the absence of hand involvement.

Clinical features from OMIM®:

609815 (Updated 05-Apr-2021)

Search Clinical Trials , NIH Clinical Center for Zygodactyly 1

Search GEO for disease gene expression data for Zygodactyly 1.