MCID: ZYG002
MIFTS: 35

Zygomycosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Zygomycosis

MalaCards integrated aliases for Zygomycosis:

Name: Zygomycosis 53 59 3 73
Mucormycosis 59 3 73

Characteristics:

Orphanet epidemiological data:

59
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA73263
MESH via Orphanet 45 D009091 D020096
UMLS via Orphanet 74 C0026718 C0043541
ICD10 33 B46 B46.5 B46.9

Summaries for Zygomycosis

CDC : 3 Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people with weakened immune systems and can occur in nearly any part of the body. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air, or the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Zygomycosis, also known as mucormycosis, is related to neutropenia and acute promyelocytic leukemia. An important gene associated with Zygomycosis is ELANE (Elastase, Neutrophil Expressed). The drugs Miconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and myeloid.

Wikipedia : 76 Zygomycosis is the broadest term to refer to infections caused by bread mold fungi of the zygomycota... more...

Related Diseases for Zygomycosis

Diseases related to Zygomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 neutropenia 28.7 CSF3 ELANE
2 acute promyelocytic leukemia 28.2 CSF3 ELANE
3 aspergillosis 10.2
4 cerebritis 10.2
5 leukemia 10.1
6 lymphoma 10.0
7 thrombosis 10.0
8 leukemia, acute myeloid 10.0
9 diabetes mellitus 10.0
10 myeloid leukemia 10.0
11 lymphoblastic leukemia 9.9
12 hematopoietic stem cell transplantation 9.9
13 leukemia, acute lymphoblastic 9.9
14 mediastinitis 9.9
15 lupus erythematosus 9.9
16 systemic lupus erythematosus 9.8
17 candidiasis 9.8
18 diabetes mellitus, ketosis-prone 9.8
19 invasive aspergillosis 9.8
20 enterocolitis 9.8
21 aging 9.8
22 burns 9.8
23 cavernous sinus thrombosis 9.8
24 myocardial infarction 9.8
25 hepatitis 9.8
26 thyroiditis 9.8
27 sinusitis 9.8
28 myelodysplastic syndrome 9.8
29 graft-versus-host disease 9.8
30 perinatal necrotizing enterocolitis 9.8
31 retinitis pigmentosa and erythrocytic microcytosis 9.8
32 acute leukemia 9.6
33 metabolic acidosis 9.6
34 fasciitis 9.6
35 acute myocardial infarction 9.6
36 panniculitis 9.6
37 necrotizing fasciitis 9.6
38 myeloma, multiple 9.6
39 brain injury 9.6
40 cutaneous t cell lymphoma 9.6
41 nocardiosis 9.6
42 chronic graft versus host disease 9.6
43 fibrosing mediastinitis 9.6
44 chronic granulomatous disease 9.6
45 endocarditis 9.6
46 laryngitis 9.6
47 pythiosis 9.6
48 leukemia, chronic myeloid 9.6
49 aneurysm 9.6
50 mastitis 9.6

Graphical network of the top 20 diseases related to Zygomycosis:



Diseases related to Zygomycosis

Symptoms & Phenotypes for Zygomycosis

Drugs & Therapeutics for Zygomycosis

Drugs for Zygomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
2
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 171228-49-2 147912
3 Steroid Synthesis Inhibitors Phase 4,Phase 2
4 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
5 Hormone Antagonists Phase 4,Phase 2
6 Hormones Phase 4,Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
8 Anti-Infective Agents Phase 4,Phase 2
9 Antifungal Agents Phase 4,Phase 2
10 Antiparasitic Agents Phase 4,Phase 2
11 Antiprotozoal Agents Phase 4,Phase 2
12
Iron Approved Phase 2 7439-89-6 23925
13
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
14
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
15 Chelating Agents Phase 2
16 Anti-Bacterial Agents Phase 2
17 Iron Chelating Agents Phase 2
18 Liposomal amphotericin B Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
2 Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis Not yet recruiting NCT03471988 Phase 3 AK1820;Voriconazole
3 Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment Completed NCT00467883 Phase 2 Liposomal Amphotericin B
4 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
5 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
6 Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis Recruiting NCT02226705 Phase 2
7 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
8 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934 Not Applicable
9 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
10 Descriptive Epidemiology on Management of Mucormycosis Completed NCT03429023
11 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
12 Mucormycosis in ICU Recruiting NCT03387696
13 Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis Not yet recruiting NCT03569904

Search NIH Clinical Center for Zygomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Zygomycosis

Anatomical Context for Zygomycosis

MalaCards organs/tissues related to Zygomycosis:

41
Lung, Skin, Myeloid, Bone, Liver, Bone Marrow, Kidney

Publications for Zygomycosis

Articles related to Zygomycosis:

(show top 50) (show all 523)
# Title Authors Year
1
Fatal Pulmonary and Cerebellar Zygomycosis due to Rhizomucor pusillus in a Ringed Seal (Pusa hispida). ( 29789990 )
2018
2
Zygomycosis-Induced Rash After Liver Transplant. ( 28381837 )
2017
3
Gastric Zygomycosis in a Previously Healthy 56-Year-Old Male. ( 28813732 )
2017
4
Epidemiology of Zygomycosis: Analysis of National Data from Pathological Autopsy Cases in Japan. ( 28855479 )
2017
5
Successful haploidentical stem cell transplantation with prophylactic administration of liposomal amphotericin B after invasive pulmonary zygomycosis. ( 28725544 )
2017
6
Survival Without Neurological Impairment of a Patient With Rhino-Orbito-Cerebral Zygomycosis. ( 27192647 )
2016
7
Gastrointestinal Zygomycosis Masquerading as Acute Appendicitis. ( 27403107 )
2016
8
Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry. ( 26668339 )
2016
9
Fulminant zygomycosis of graft liver following liver transplantation. ( 26873918 )
2016
10
Zygomycosis Presenting as Acute Bilateral Renal Artery Thrombosis. ( 27731578 )
2016
11
Epidemiological aspects and clinical outcome of patients with Rhinocerebral zygomycosis: a survey in a referral hospital in Iran. ( 27800087 )
2016
12
Rhinocerebral Zygomycosis with Orosinusal Involvement: Diagnostic and Surgical Treatment Guidelines. ( 28017141 )
2016
13
Rhinocerebral zygomycosis: an unusual dramatic presentation in a paediatric cardiac patient without risk factors. ( 28533711 )
2016
14
Subcutaneous Zygomycosis: A Report of One Case Responding Excellently to Potassium Iodide. ( 26538702 )
2015
15
Zygomycosis Presenting as Acute Bilateral Renal Artery Thrombosis in a Healthy Young Male. ( 26591179 )
2015
16
Challenges in the management of invasive pulmonary zygomycosis: the Alfred experience. ( 26429509 )
2015
17
Severe invasive pulmonary zygomycosis by Rhizomucor pusillus and concomitant severe bacterial endocarditis in acute promyelocytic leukaemia. ( 26397298 )
2015
18
Acute cutaneous zygomycosis of the scalp: A case report and literature review. ( 25843449 )
2015
19
Aggressive cutaneous zygomycosis caused by Apophysomyces variabilis in an immunocompetent child. ( 26858932 )
2015
20
When you can't see the wood for the trees. Mucor circinelloides: A rare case of primary cutaneous zygomycosis. ( 25840851 )
2015
21
Pulmonary zygomycosis in a diabetic patient: treated with pneumonectomy and antifungal agents. ( 25181747 )
2014
22
Rhino facial zygomycosis: case report. ( 25167339 )
2014
23
Isolated renal zygomycosis in an immunocompetent patient. ( 24903721 )
2014
24
Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia. ( 24827491 )
2014
25
A case of subcutaneous zygomycosis. ( 24616857 )
2014
26
Evaluation of patients with zygomycosis. ( 25558652 )
2014
27
Breakthrough disseminated zygomycosis induced massive gastrointestinal bleeding in a patient with acute myeloid leukemia receiving micafungin. ( 25796921 )
2014
28
Diagnostic discussion. Zygomycosis (mucormycosis). ( 24812801 )
2014
29
Primary cutaneous zygomycosis secondary to minor trauma in an immunocompromised pediatric patient: a case report. ( 24945642 )
2014
30
Subcutaneous zygomycosis in children: 2 case reports. ( 25391201 )
2014
31
Disseminated zygomycosis caused by Cunninghamella bertholletiae in patient with hematological malignancy and review of published case reports. ( 23124364 )
2013
32
An autopsy case of pulmonary fissure induced by zygomycosis. ( 23874118 )
2013
33
Posaconazole pharmacokinetics in a 2-year-old boy with rhino-cerebral-orbital zygomycosis. ( 23307552 )
2013
34
Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature. ( 24325793 )
2013
35
Subcutaneous mucor zygomycosis with potential life-threatening visceral complication. ( 23867678 )
2013
36
Rhizomucor variabilis: a rare causative agent of primary cutaneous zygomycosis. ( 23883723 )
2013
37
Infected with mold! Zygomycosis: A case report. ( 24376156 )
2013
38
Zygomycosis in children: disseminated infection caused by Cunninghamella bertholletiae. ( 23099279 )
2013
39
Neonatal zygomycosis with gastric perforation. ( 23942436 )
2013
40
The Sinus That Breeds Fungus: Subcutaneous Zygomycosis Caused by Basidiobolus ranarum at the Injection Site. ( 24349806 )
2013
41
Disseminated zygomycosis due to Mycocladus corymbifera with cutaneous and cerebral involvement. ( 23373895 )
2013
42
Fatal-mixed cutaneous zygomycosis-aspergillosis: a case report. ( 24085614 )
2013
43
Liposomal amphotericin B and surgery as successful therapy for pulmonary Lichtheimia corymbifera zygomycosis in a pediatric patient with acute promyelocytic leukemia on antifungal prophylaxis with posaconazole. ( 23307250 )
2013
44
Multiple ring enhancing lesions in brain due to disseminated Zygomycosis in a renal transplant recipient. ( 23710934 )
2013
45
Subcutaneous zygomycosis caused by Mucor hiemalis in an immunocompetent patient. ( 23940499 )
2013
46
Fatal primary cutaneous zygomycosis caused by Saksenaea vasiformis: case report and review of literature. ( 22280152 )
2012
47
The reversed halo sign as the initial radiographic sign of pulmonary zygomycosis. ( 21735109 )
2012
48
Novel magnetic resonance imaging findings in renal zygomycosis. ( 21924461 )
2012
49
Pulmonary zygomycosis with Cunninghamella bertholletiae in a killer whale (Orcinus orca). ( 22000035 )
2012
50
Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide. ( 22369887 )
2012

Variations for Zygomycosis

Expression for Zygomycosis

Search GEO for disease gene expression data for Zygomycosis.

Pathways for Zygomycosis

GO Terms for Zygomycosis

Sources for Zygomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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